Chromatin dynamics and the regulation of B-glohin gene expression
(De dynamiek van chromatine en de regulatie van B-globine gen expressie)
1998-06-10
Doctoral Thesis
| Related Files |
|---|
View PDF Version
(980610_WIJGERDE, Marcus Govert Johannes Maria.pdf, 4.0MB) |
|
View PDF Version
(Stellingen.pdf, 0.1MB) |
The human B-globin locus is frequently used as a model system to study mechanisms controlling tissue-specific and developmentally regulated gene expression. Much of the recent progress in understanding the regulation of B-globin gene expression has come from a better knowledge of the process of transcription. Proper transcriptional regulation of the human B-globin genes occurs, at least in part, through specific interactions of regulatory traus-acting proteins to defined cis-regulatory sequences that include promoters, enhancers, silencers, and elements of the locus control region.
Supervisor
(promotor):
The
author
wishes to thank:
NWO
Keywords
Automatically Extracted Terms
- expression
- transcription
- globin
- locus
- region
- factor
- erythroid
- signal
- promoter
- p-globin
- transcriptional
- level
- chromatin
- result
- protein
- sequence
- grosveld
- adult
- erythroid cells
- control
