http://hdl.handle.net/1765/22488

pubmed: 15090569



Arterial oxygen saturation, COPD, and cerebral small vessel disease


Article
volume 75, issue 5 pp 733-736.
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OBJECTIVE: To study whether lower arterial oxygen saturation (SaO(2)) and chronic obstructive pulmonary disease (COPD) are associated with cerebral white matter lesions and lacunar infarcts. METHODS: We measured SaO(2) twice with a pulse oximeter, assessed the presence of COPD, and performed MRI in 1077 non-demented people from a general population (aged 60-90 years). We rated periventricular white matter lesions (on a scale of 0-9) and approximated a total subcortical white matter lesion volume (range 0-29.5 ml). All analyses were adjusted for age and sex and additionally for hypertension, diabetes, body mass index, pack years smoked, cholesterol, haemoglobin, myocardial infarction, and left ventricular hypertrophy. RESULTS: Lower SaO(2) was independent of potential confounders associated with more severe periventricular white matter lesions (score increased by 0.12 per 1% decrease in SaO(2) (95% confidence interval 0.01 to 0.23)). Participants with COPD had more severe periventricular white matter lesions than those without (adjusted mean difference in score 0.70 (95% confidence interval 0.23 to 1.16)). Lower SaO(2) and COPD were not associated with subcortical white matter lesions or lacunar infarcts. CONCLUSION: Lower SaO(2) and COPD are associated with more severe periventricular white matter lesions.



Keywords


Automatically Extracted Terms
  • matter lesions
  • matter
  • lesion
  • sao 2
  • study
  • oxygen
  • periventricular
  • lacunar infarcts
  • participant
  • oxygen saturation
  • blood
  • subcortical
  • matter lesion volume
  • infarct
  • body mass index
  • pack years
  • oxygen pressure
  • people
  • lacunar
  • disease


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