EUR > Medicine & Health > Erasmus MC > Sophia > Pediatrics > View Doctoral Thesis
http://hdl.handle.net/1765/23424
isbn: 978-946169-051-7

Unraveling Mill-Rearranged Pedriatic Acute Myeloid Leukemia

(Het ontrafelen van acute myeloïde leukemie met een MLL-gen herschikking in kinderen)


Doctoral Thesis
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Blood cells are derived from hematopoietic stem cells (HSC) that reside in the bone marrow. HSC’s are multipotent and have the capacity to diff erentiate into the cells of all blood lineages, i.e. erythrocytes, platelets, neutrophils, eosinophils, basophils, monocytes, T and B lymphocytes, natural killer cells, and dendritic cells. Leukemia is cancer of the blood in which the normal population of blood cells in the bone marrow is replaced by immature blood cells (blasts). Th ese immature cells occur due to an imbalance in diff erentiation and proliferation. Accumulation of these malignant cells in the bone marrow results in decrease of normal mature blood cells, like white blood and red blood cells and platelets.


Supervisor (promotor):

Prof. Dr. Pieters, R.

The author wishes to thank:

NWO,
Novartis,
Genzyme,
MRC-Holland BV,
Pediatric Oncology Foundation Rotterdam


Keywords


Automatically Extracted Terms
  • leukemia
  • myeloid leukemia
  • patient
  • expression
  • mutation
  • myeloid
  • study
  • brian
  • mll-rearranged
  • bw.indd
  • 31-03-11
  • group
  • mll-rearranged aml
  • aberration
  • blood
  • probe
  • outcome
  • cytogenetic
  • children
  • mll-ptd


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