http://hdl.handle.net/1765/23606




Differential effects of age, cytomegalovirus-seropositivity and end-stage renal disease (ESRD) on circulating T lymphocyte subsets


Article
volume 8.
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The age- and cytomegalovirus (CMV)-seropositivity-related changes in subsets and differentiation of circulating T cells were investigated in end-stage renal disease (ESRD) patients (n = 139) and age-matched healthy individuals. The results show that CMV-seropositivity is associated with expansion of both CD4+and CD8+memory T cells which is already observed in young healthy individuals. In addition, CMV-seropositive healthy individuals have a more differentiated memory T cell profile. Only CMV-seropositive healthy individuals showed an age-dependent decrease in CD4+näve T cells. The age-related decrease in the number of CD8+näve T cells was CMV-independent. In contrast, all ESRD patients showed a profound näve T-cell lymphopenia at every decade. CMV-seropositivity aggravated the contraction of CD4+näve T cells and increased the number of differentiated CD4+and CD8+memory T cells. In conclusion, CMV-seropositivity markedly alters the homeostasis of circulating T cells in healthy individuals and aggravates the T cell dysregulation observed in ESRD patients.



Keywords


Automatically Extracted Terms
  • esrd patients
  • patient
  • 0.01
  • number
  • memory
  • lymphocytes
  • 0.02
  • t cells
  • subset
  • individual
  • cd 4+
  • t lymphocytes
  • 0.03
  • cmv-seropositivity
  • tnaive
  • <0.01
  • effect
  • t lymphocyte subsets
  • study
  • ageing


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