http://hdl.handle.net/1765/25596

pubmed: 20631901
scopus: cited times

Genetics of uveal melanoma and cutaneous melanoma: two of a kind?


Article
volume 2010 pp 360136-13.
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Cutaneous melanoma and uveal melanoma both derive from melanocytes but show remarkable differences in tumorigenesis, mode of metastatic spread, genetic alterations, and therapeutic response. In this review we discuss the differences and similarities along with the genetic research techniques available and the contribution to our current understanding of melanoma. The several chromosomal aberrations already identified prove to be very strong predictors of decreased survival in CM and UM patients. Especially in UM, where the overall risk of metastasis is high (45%), genetic research might aid clinicians in selecting high-risk patients for future systemic adjuvant therapies.



Keywords


Automatically Extracted Terms
  • melanoma
  • chromosome
  • uveal
  • tumor
  • research
  • uveal melanoma
  • mutation
  • cancer
  • ophthalmology
  • cm cm
  • monosomy 3
  • patient
  • journal
  • monosomy
  • fication
  • metastatic
  • metastasi
  • expression
  • analysis
  • prognostic


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