Activation by Locus Control Regions?
1999-04-15
Article
volume 9, issue 2 pp 152-157.
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On the basis of homologous recombination experiments to delete the murine beta-globin locus control region (LCR) in embryonic stem cells, it was recently suggested that the LCR is not required for the activation of the murine beta-globin locus. This conclusion is in direct contradiction to the findings and conclusions that have been obtained with the human beta-globin LCR; thus the murine and human LCR may functionally be different or there may be a different interpretation of the results.
Keywords
- Animals
- Humans
- Gene Transfer Techniques
- Gene Deletion
- Transgenes
- Globins/*genetics
- Thalassemia/genetics
- Chromosomes
- *Locus Control Region
