Chronic rejection in DLA identical dogs after orthotopic cardiac transplantation


Doctoral Thesis
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The justification for clinical cardiac transplantation is that it should solve end-stage cardiac disease when no other medical or surgical treatment is available (76). However, after cardiac transplantation the main barriers to long-term survival and complete rehabilitation include the management of acute rejection episodes, the complications related to the immunosuppressive therapy and the progression of graft arteriosclerosis or chronic rejection (77). Although a progressive increase in patient survival has become apparent (77), many aspects of the process of acute and chronic cardiac allograft rejection have yet to be studied.


Supervisor (promotor):

Bos, E.

The author wishes to thank:

Netherlands Heart Foundation
Hippocrates Studiefonds


Keywords


Automatically Extracted Terms
  • transplantation
  • heart
  • rejection
  • biopsy
  • orthotopic
  • marker
  • change
  • method
  • study
  • contractility
  • allograft
  • heart transplantation
  • surgery
  • technique
  • result
  • shumway
  • chapter
  • survival
  • peak dp /dt
  • journal