Studies on cholesterol side-chain cleavage in adrenal cortex mitochondria : proposal of a new mechanism
1978-01-20
Doctoral Thesis
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The enzymic conversion of cholesterol into pregnenolone involves a cleavage of the cholesterol. side-chain, yielding two fragments: pregnenolone and isocaproaldehyde (fig. 1.1). This process, the rate limiting step in the biosynthesis of the steroid hormones, is generally known as the "cholesterol side-chain cleavage" reaction. All the enzymes required for this conversion are located in the mitochondria of the adrenal cell, while the main regulating factor is the adrenocorticotropic hormone (ACTH) .
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Keywords
Automatically Extracted Terms
- cholesterol
- 22 r-oh cholesterol
- pregnenolone
- 20 a-oh cholesterol
- cleavage
- side-chain
- reaction
- oxygen
- mitochondria
- conversion
- cytochrome
- cholesterol side-chain cleavage
- cytochrome p -450scc
- cortex mitochondria
- formation
- 22 cholesterol
- experiment
- result
- compound
- presence
