http://hdl.handle.net/1765/29955

pubmed: 18322669
scopus: 43449123026



Prorenin anno 2008


Article
volume 86, issue 6 pp 655-658.
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For many years, prorenin has been considered to be nothing more than the inactive precursor of renin. Yet, its elevated levels in diabetic subjects with microvascular complications and its extrarenal production at various sites in the body suggest otherwise. This review discusses the origin, regulation, and enzymatic activity of prorenin, its role during renin inhibition, and the angiotensin-dependent and angiotensin-independent consequences of its binding to the recently discovered (pro)renin receptor. The review ends with the concept that prorenin rather than renin determines tissue angiotensin generation.



Keywords


Automatically Extracted Terms
  • prorenin
  • renin
  • receptor
  • angiotensin
  • activation
  • danser
  • effect
  • derkx fhm
  • tissue
  • plasma
  • level
  • binding
  • tissue angiotensin generation
  • generation
  • burckl é c
  • suzuki f
  • schalekamp madh
  • renin inhibitors
  • renin inhibition
  • nakagawa t


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