Localization of the nucleotide excision repair gene ERCC-6 to human chromosome 10q11-q21.
January 1992
Article
volume 12 pp 745-749.
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We have cloned the human DNA excision repair gene ERCC6 by virtue of its ability to correct the uv sensitivity of Chinese hamster overy cell mutant UV61. This mutant is a member of complementation group 6 of the nucleotide excision repair-deficient rodent mutants. By means of in situ hybridization and Southern blot analysis of mouse x human somatic cell hybrids, the gene was localized to human chromosome 10q11-q21. An RFLP detected within the ERCC6 locus can be helpful in linkage analysis.
Keywords
- Male
- Animals
- Human
- Support, Non-U.S. Gov't
- Female
- Ultraviolet Rays
- CHO Cells
- Hamsters
- Mutation
- Restriction Mapping
- Chromosome Mapping
- Hybrid Cells
- Linkage (Genetics)
- DNA Repair/*genetics/radiation effects
- Pedigree
- Polymorphism, Restriction Fragment Length
- *Chromosomes, Human, Pair 10
