EUR > Medicine & Health > Erasmus MC > View Doctoral Thesis
http://hdl.handle.net/1765/31605

Quasi-morphine abstinence behaviour GABA-ergic mechanisms and their localization

(Kwasi-morfine onthoudingsgedrag opgewekt door dipropylacetaat in de rat: mechanismen en aangrijpingspunten)


Doctoral Thesis
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Di-n-propylacetate (DPA), generally known to be an anti-epileptic drug, induces a behavioural syndrome in rats resembling morphine abstinence behaviour, which is called, therefore, quasi-morphine abstinence beh~viour. An increase in GABA-ergic activity is probably responsible for this behavioural effect of DPA, since it has been shown to be suppressed by GABA-antagonists like bicuculline and picrotoxin. The experiments presented in this thesis were designed to investigate the central mechanisms involved in this quasi-morphine abstinence behaviour.


Supervisor (promotor):

Prof. Dr. Bruinvels, J.


Keywords


Automatically Extracted Terms
  • behaviour
  • brain
  • morphine
  • activity
  • effect
  • abstinence
  • injection
  • concentration
  • gaba-t
  • inhibition
  • morphine abstinence behaviour
  • gaba-ergic
  • ssa-dh
  • system
  • mechanism
  • action
  • level
  • quasi-morphine abstinence behaviour
  • increase
  • administration


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