Studies in primary biliary cirrhosis
1981-11-18
Doctoral Thesis
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The specific aims of the study were: - To (re)define the clinical features of the primary biliary cirrhosis syndrome. - To develop objective criteria which combine specificity with sensitivity for the diagnosis of PBC. - To study the relation of IgM in various forms (pentameric, monomeric and cryoglobulin) to the activity of the non-suppurative destructive cholangitis. - To test the therapeutic effects of 'go-slow-golow' D-penicillamine therapy in a randomized controlled trial, and to determine whether any favourable effects were due to a reduction of hepatic copper or to a decrease of immunological disturbances. - To perform a pilot study for evaluation of the effect of a combined therapy with small doses of D-penicillamine and prednisone
Supervisor
(promotor):
Keywords
Automatically Extracted Terms
- patient
- biliary cirrhosis
- serum
- liver
- cirrhosis
- disease
- biliary
- group
- d-penicillamine
- method
- control
- cryoglobulin
- liver disease
- therapy
- study
- pbc patients
- serum igm
- criteria
- antibody
- treatment
