Maintenance of immunological memory: A role for CD5+ B cells?
December 1991
Article
volume 12, issue 12 pp 439-442.
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How memory is retained is an immunological mystery. One possibility, argued here by Fons UytdeHaag and colleagues, is that memory is imprinted in the somatically-mutated Ig expressed by certain CD5+ B cells. The theory proposes that the Ig expressed by this self-renewing population acts as surrogate antigen, selecting and stimulating emerging antigen-specific lymphocytes.
Keywords
- Animals
- Human
- Support, Non-U.S. Gov't
- Mice
- Mutation
- Models, Biological
- Genes, Immunoglobulin
- Immunoglobulin Variable Region/genetics
- 0 (Antibodies, Anti-Idiotypic)
- *Antigens, CD
- *Gene Rearrangement, B-Lymphocyte
- *Immunologic Memory
- 0 (Antigens, CD)
- 0 (Antigens, CD5)
- 0 (Immunoglobulin Variable Region)
- 0 (Immunoglobulins, Heavy-Chain)
- 0 (Immunoglobulins, Light-Chain)
- 0 (Immunoglobulins, Surface)
- Antibodies, Anti-Idiotypic/genetics/immunology
- Antigens, CD5
- B-Lymphocyte Subsets/*immunology
- Hematopoietic Stem Cells/immunology
- Immunoglobulins, Heavy-Chain/genetics
- Immunoglobulins, Light-Chain/genetics
- Immunoglobulins, Surface/genetics/*immunology
- Plasma Cells/immunology
Automatically Extracted Terms
- b cells
- memory
- antigen
- immunol
- antibody
- network
- region
- b-cell
- antibody v regions
- b-cell clones
- response
- clone
- arrow
- anti-idiotypic
- today
- maintenance
- connectivity
- affinity
- v regions
- t cells
