Neutralization of feline immunodeficiency virus by polyclonal cat antibody: Simultaneous involvement of hypervariable regions 4 and 5 of the surface glycoprotein.
January 1995
Article
volume 69 pp 5124-5127.
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Sites involved in antibody-mediated neutralization of feline immunodeficiency virus were mapped by reciprocal exchange of envelope fragments or amino acids between molecular clones of feline immunodeficiency virus with different susceptibilities to neutralization by a polyclonal cat serum. Combinations of mutations within HV-4 or within HV-4 and HV-5 changed the susceptibility of the viruses to neutralizing antibody.
Keywords
- Animals
- Cell Line
- Support, Non-U.S. Gov't
- Cloning, Molecular
- Dogs
- Point Mutation
- Neutralization Tests
- 0 (Viral Proteins)
- 0 (Antibodies, Viral)
- Antibodies, Viral/*immunology
- Viral Proteins/*immunology
- 0 (Immune Sera)
- Immune Sera
- Immunodeficiency Virus, Feline/*immunology
- 0 (Membrane Glycoproteins)
- Membrane Glycoproteins/*immunology
Automatically Extracted Terms
- fiv 19k
- virus
- immunodeficiency virus
- immunodeficiency
- neutralization
- n-linked glycosylation site
- position
- region
- immunodeficiency virus infection
- hv -4
- clone
- antibody
- virol
- infection
- su protein
- mutation
- glycosylation
- protein
- envelope
- virus neutralization
