Characterization of a novel coronavirus associated with severe acute respiratory syndrome
2003-05-30
Article
volume 300, issue 5624 pp 1394-1399.
(Epub 2003 May 1)
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In March 2003, a novel coronavirus (SARS-CoV) was discovered in association with cases of severe acute respiratory syndrome (SARS). The sequence of the complete genome of SARS-CoV was determined, and the initial characterization of the viral genome is presented in this report. The genome of SARS-CoV is 29,727 nucleotides in length and has 11 open reading frames, and its genome organization is similar to that of other coronaviruses. Phylogenetic analyses and sequence comparisons showed that SARS-CoV is not closely related to any of the previously characterized coronaviruses.
Keywords
- Humans
- Amino Acid Sequence
- Molecular Sequence Data
- Regulatory Sequences, Nucleic Acid
- Phylogeny
- Transcription, Genetic
- Conserved Sequence
- Sequence Analysis, DNA
- DNA, Complementary
- RNA, Messenger/genetics/metabolism
- Open Reading Frames
- *Genome, Viral
- Coronavirus/classification/genetics
- Endopeptidases/chemistry/genetics
- Membrane Glycoproteins/chemistry/genetics
- Nucleocapsid Proteins/chemistry/genetics
- RNA Replicase/chemistry/genetics
- Polyproteins/chemistry/genetics
- RNA, Viral/*genetics
- SARS Virus/chemistry/classification/*genetics/isolation & purification
- Severe Acute Respiratory Syndrome/virology
- Viral Envelope Proteins/chemistry/genetics
- Viral Matrix Proteins/chemistry/genetics
- Viral Proteins/chemistry/*genetics
