EUR > Medicine & Health > Erasmus MC > View Doctoral Thesis
http://hdl.handle.net/1765/7999

Modulation of Synaptic Transmission by Metabotropic Glutamate Receptors and Endocannabinoid Signaling

(Modulatie van synaptische transmissie door metabotrope glutamaat receptoren en endocannabinoiden)


Doctoral Thesis
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(060927_Yelahanka Nagaraja, Raghavendra.pdf, 2.9MB)
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Metabotropic glutamate receptors (mGluRs) are distributed throughout the central nervous system and play important roles in the modulation of synaptic transmission. The mGluRs regulate long-term potentiation (LTP)/long-term depression (LTD) and learning and memory in hippocampus. This group of glutamate receptors are also reported to exert anticonvulsive and neuroprotective efficacy, especially group I mGluRs. Kindling induced by repeated application of the convulsant pentylenetetrazole (PTZ) is a validated model of epilepsy and epilepsy-related neuromorphological, neurophysiological and behavioural alterations. In this thesis, the role of group I metabotropic glutamate receptors (mGluRs) in PTZ induced seizures, kindling, kindling-related learning deficits and LTP were examined.


Supervisor (promotor):

Prof. Dr. Zeeuw, C.I. de

The author wishes to thank:

Zeeuw, Prof. Dr. C.I. de (promotor)
Olympus Nederland
Heka Electronik




Automatically Extracted Terms
  • mglur
  • receptor
  • kindling
  • glutamate
  • synaptic
  • group
  • mglur 1
  • effect
  • potentiation
  • induction
  • cerebellar
  • metabotropic
  • plasticity
  • hippocampal
  • seizure
  • presynaptic
  • activation
  • brain
  • antagonist
  • activity


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