http://hdl.handle.net/1765/8521

Bronchodilation in infants with malacia or recurrent wheeze


Article
Related Files
asset icon
(12598393.pdf, 0.2MB)

BACKGROUND: Controversy remains regarding the effectiveness of bronchodilators in wheezy infants. AIMS: To assess the effect of inhaled beta(2) agonists on lung function in infants with malacia or recurrent wheeze, and to determine whether a negative effect of beta(2) agonists on forced expiratory flow (V'(maxFRC)) is more pronounced in infants with airway malacia, compared to infants with wheeze. METHODS: We retrospectively analysed lung function data of 27 infants: eight with malacia, 19 with recurrent wheeze. Mean (SD) age was 51 (18) weeks. Mean V'(maxFRC) (in Z score) was assessed before and after inhalation of beta(2) agonists. RESULTS: Baseline V'(maxFRC) was below reference values for both groups. Following inhalation of beta(2) agonists the mean (95% CI) change in mean V'(maxFRC) in Z scores was -0.10 (-0.26 to 0.05) and -0.33 (-0.55 to -0.11) for the malacia and wheeze group, respectively. CONCLUSIONS: In infants with wheeze, inhaled beta(2) agonists caused a significant reduction in mean V'(maxFRC). Infants with malacia were not more likely to worsen after beta(2) agonists than were infants with recurrent wheeze.



Keywords


Automatically Extracted Terms
  • infant
  • agonist
  • vmaxfrc
  • wheeze
  • airway
  • malacia
  • 2 agonist administration
  • group
  • wheeze group
  • 2 agonists
  • airway malacia
  • wheezy infants
  • bronchodilation
  • measurement
  • function
  • effect
  • article
  • technique
  • reduction
  • administration


Bookmark with: