Inhibitory effects of acyclic nucleoside phosphonates on human hepatitis B virus and duck hepatitis B virus infections in tissue culture
January 1994
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The inhibitory effects of the 9-(2-phosphonylmethoxyethyl)adenine-related compounds (S)-9-(3-hydroxy-2-phosphonylmethoxypropyl)-adenine, (S)-9-(3-fluoro-2-phosphonylmethoxypropyl)adenine, (R)-9-(2-phosphonylmethoxypropyl)adenine, (R)-9-(2-phosphonylmethoxypropyl)-2,6-diaminopurine, and (S)-1-(3-hydroxy-2-phosphonylmethoxypropyl)cytosine on human hepatitis B virus replication in the human hepatoma cell line HepG2 2.2.15 and duck hepatitis B virus infection in primary duck hepatocytes were investigated. (R)-9-(2-phosphonylmethoxypropyl-2,6-diaminopurine had the lowest 50% inhibitory concentrations against hepatitis B virus and duck hepatitis B virus, 0.22 and 0.06 microM, respectively, i.e., two- to fivefold lower concentrations than required for (R)-9-(2-phosphonylmethoxypropyl)adenine and 9-(2-phosphonylmethoxyethyl)adenine. All compounds were not toxic in vitro at a concentration of 100 microM.
- Animals
- Humans
- Tumor Cells, Cultured
- Antiviral Agents/*pharmacology
- Carcinoma, Hepatocellular/virology
- Adenine/analogs & derivatives/pharmacology
- Cytosine/analogs & derivatives
- Ducks
- Hepatitis B Virus, Duck/*drug effects
- Hepatitis B virus/*drug effects
- Liver Neoplasms/virology
- Liver/cytology/virology
- Nucleosides/*pharmacology
- Organophosphorus Compounds/pharmacology
- Phosphonic Acids/*pharmacology
- Purines/pharmacology
- virus
- acyclic nucleoside phosphonates
- hepatitis
- 2.2.15
- hepatocyte
- compound
- >100
- ic 50
- hepatitis b virus
- duck hepatocytes
- dhbv-infected duck hepatocytes
- concentration
- nucleoside
- activity
- phosphonate
- infection
- effect
- acyclic
- agents chemother
- clercq
