http://hdl.handle.net/1765/8898

Superior efficacy of liposomal amphotericin B with prolonged circulation in blood in the treatment of severe candidiasis in leukopenic mice


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In leukopenic mice with severe systemic candidiasis, single-dose treatment (5 mg of amphotericin B [AMB]/kg of body weight) with long-circulating polyethylene glycol-coated AMB liposomes (PEG-AMB-LIP) resulted in zero mortality and a significant reduction in the number of viable Candida albicans in the kidney, whereas 70% mortality was seen in mice treated with five daily doses of AmBisome (5 mg of AMB/kg . day). When the first of five daily doses of AmBisome was combined with a single low dose of Fungizone (0.1 mg of AMB/kg), the efficacy was equal to that of PEG-AMB-LIP.



Keywords


Automatically Extracted Terms
  • treatment
  • ambisome
  • albicans
  • peg-amb-lip
  • fungizone
  • inoculation
  • albicans inoculation
  • number
  • efficacy
  • antifungal activity
  • amb /kg
  • multidose ambisome
  • kidney
  • multidose
  • effect
  • antifungal
  • amb /kg day
  • table
  • liposomes
  • leukopenic


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