Sequence variation in a newly identified HLA-B35-restricted epitope in the influenza A virus nucleoprotein associated with escape from cytotoxic T lymphocytes
January 2002
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Here, we describe a new HLA-B*3501-restricted cytotoxic T lymphocyte (CTL) epitope in the influenza A virus (H3N2) nucleoprotein, which was found to exhibit a high degree of variation at nonanchor residues. The influenza virus variants emerged in chronological order, and CTLs directed against old variants failed to recognize more recent strains of influenza A virus, indicating an escape from CTL immunity.
Keywords
- Humans
- Research Support, Non-U.S. Gov't
- Amino Acid Sequence
- Molecular Sequence Data
- T-Lymphocytes, Cytotoxic/*immunology
- *RNA-Binding Proteins
- Antigenic Variation
- Epitopes/*immunology
- HLA-B35 Antigen/*metabolism
- Influenza A virus/genetics/*immunology
- Nucleoproteins/*genetics/*immunology
- Viral Core Proteins/*genetics/*immunology
Automatically Extracted Terms
- epitope
- virus
- influenza
- hla-b
- variant
- target cells
- peptide
- np 418-426/1980 epitope
- cytotoxic
- clone
- donor
- 418-426/1980
- np 418-426 epitope
- mutation
- 418-426/1972
- target
- recognition
- hla-a
- 418-426
- variation
