2026-05-31T22:57:18Z https://repub.eur.nl/oai

oai:repub.eur.nl:126720 2023-11-26T18:43:21Z

urn:NBN:nl:ui:15-1765/126720 2023-11-26T18:43:21 mods http://hdl.handle.net/1765/126720 hdl:1765/126720 urn:NBN:nl:ui:15-1765/126720 doi:10.1002/mnfr.201900696 http://hdl.handle.net/1765/126720 https://repub.eur.nl/pub/126720/Repub_126720_O-A.pdf application/pdf Filesize: 1141366 bytes born digital Department of Gynaecology & Obstetrics sht supporting host Department of Bioinformatics sht supporting host J. Hoek (Jeffrey) Hoek Jeffrey aut author R.P.M. Steegers-Theunissen (Régine) Steegers-Theunissen Régine aut author S.P. Willemsen (Sten) Willemsen Sten aut author S. Schoenmakers (Sam) Schoenmakers Sam aut author Scope: The effectiveness of maternal folate in reducing the risk of congenital malformations during pregnancy is well established. However, the role of the paternal folate status is scarcely investigated. The aim of this study is to investigate the evidence of associations between the paternal folate status and sperm quality, sperm epigenome, and pregnancy outcomes. Methods and results: Databases are searched up to December 2017 resulting in 3682 articles, of which 23 are retrieved for full-text assessment. Four out of thirteen human and two out of four animal studies show positive associations between folate concentrations and sperm parameters. An additional meta-analysis of four randomized controlled trials in subfertile men shows that the sperm concentration increases (3.54 95% confidence interval (CI) [−1.40 to 8.48]) after 3–6 months of 5 mg folic acid use per day compared to controls. Moreover, two out of two animal and one out of three human studies show significant alterations in the overall methylation of the sperm epigenome. One animal and one human study show associations between low folate intake and an increased risk of congenital malformations. Conclusions: This systematic review and meta-analysis shows evidence of associations between paternal folate status and sperm quality, fertility, congenital malformations, and placental weight. Molecular Nutrition & Food Research (Print) 11669 16134125 64 9 2020-05-01 en English congenital malformations epigenetics fertility folate folic acid supplements placenta sperm quality Paternal Folate Status and Sperm Quality, Pregnancy Outcomes, and Epigenetics A Systematic Review and Meta-Analysis text info:eu-repo/semantics/other 109961315 http://purl.org/eprint/accessRights/OpenAccess