2026-09-18T22:01:10Z https://repub.eur.nl/oai

oai:repub.eur.nl:98975 2025-11-03T21:36:09Z

http://hdl.handle.net/1765/98975 hdl:1765/98975 urn:NBN:nl:ui:15-1765/98975 978-94-6332-167-9 http://hdl.handle.net/1765/98975 https://repub.eur.nl/pub/98975/170503_Matthijsse-Suzetta-Maria.pdf application/pdf Filesize: 4274797 bytes born digital S.M. Matthijsse (Suzette) Matthijsse Suzette aut author Human papillomavirus (HPV) is a highly prevalent sexually transmitted virus, of which 150 types have been completely sequenced. Currently, about 14 HPV-types are considered ‘high risk’ for their potential to cause cervical cancer, the fourth most common cancer among women worldwide. In particular HPV-16 and HPV-18 are predominantly present in precancerous lesions and invasive cervical cancer. Luckily, vaccines have been developed to protect against these HPV-types. This thesis includes modeling studies in which we explore the role of naturally acquired immunity after clearing an HPV-16 and HPV-18 infection in the spread of HPV, as well as the impact of HPV vaccination on HPV and cervical cancer in the Netherlands. Erasmus University Rotterdam 2017-05-03 en English Human papillomavirus HPV cervical cancer vaccination screening mathematical modeling microsimulation The impact of HPV vaccination on HPV and cervical cancer in the Netherlands text dissertation