2024-03-28T14:25:22Z
https://repub.eur.nl/oai
oai:repub.eur.nl:137157
2024-03-13T14:49:10Z
http://hdl.handle.net/1765/137157
hdl:1765/137157
urn:NBN:nl:ui:15-1765/137157
doi:10.3389/fsoc.2024.1194597
http://hdl.handle.net/1765/137157
https://repub.eur.nl/pub/137157/ERS-2023-003-LIS_v2.pdf
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Erasmus Research Institute of Management
sht
supporting host
M.C. Schippers (Michaéla)
Schippers
Michaéla
aut
author
J.P.A. Ioannidis (John)
Ioannidis
John
aut
author
M.W.J. Luijks (Matthias)
Luijks
Matthias
aut
author
Just like an army of ants caught in an ant mill, individuals, groups and even whole societies are sometimes caught up in a Death Spiral, a vicious cycle of self-reinforcing dysfunctional behavior characterized by continuous flawed decision making, myopic single-minded focus on one (set of) solution(s), denial, distrust, micromanagement, dogmatic thinking and learned helplessness. We propose the term Death Spiral Effect to describe this difficult-to-break downward spiral of societal decline. Specifically, in the current theory-building review we aim
to: (a) more clearly define and describe the Death Spiral Effect; (b) model the downward spiral of societal decline as well as an upward spiral; (c) describe how and why individuals, groups and even society at large might be caught up in a Death Spiral; and (d) offer a positive way forward in terms of evidence-based solutions to escape the Death Spiral Effect. Management theory hints on the occurrence of this phenomenon and offers turn-around leadership as solution. On a societal level strengthening of democracy may be important. Prior research indicates that historically, two key factors trigger this type of societal decline: rising inequalities creating an upper layer of elites and a lower layer of masses; and dwindling (access to) resources. Historical key markers of societal decline are a steep increase in inequalities, government overreach, over-integration (interdependencies in networks) and a rapidly decreasing trust in institutions and resulting collapse of legitimacy. Important issues that we aim to shed light on are the behavioral underpinnings of decline, as well as the
question if and how societal decline can be reversed. We explore the extension of these theories from the company/organization level to the society level, and make use of insights from both micro-, meso-, and macro-level theories (e.g., Complex Adaptive Systems and collapsology, the study of the risks of collapse of industrial civilization) to explain this process of societal demise. Our review
furthermore draws on theories such as Social Safety Theory, Conservation of Resources Theory, and management theories that describe the decline and fall of groups, companies and societies, as well as offer ways to reverse this trend.
ERIM Report Series Research in Management
2
ERS-2023-003-LIS
2024-03-08
en
English
Death Spiral Effect
complex adaptive systems
Societal Collapse
Income Inequalities
Dysfunctional Behavior
Elite and Masses
Turnaround Leadership
Strengthening of Democracy
Is Society caught up in a Death Spiral? Modeling Societal Demise and its Reversal
text
researchPaper
160992486
oai:repub.eur.nl:123844
2024-03-04T15:05:57Z
http://hdl.handle.net/1765/123844
hdl:1765/123844
urn:NBN:nl:ui:15-1765/123844
978-90-76665-56-6
http://hdl.handle.net/1765/123844
https://repub.eur.nl/pub/123844/123844.pdf
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ERMeCC, Erasmus Research Centre for Media, Communication and Culture, Rotterdam
dgg
degree grantor
ERMeCC, Erasmus Research Centre for Media, Communication and Culture, Rotterdam
sht
supporting host
Y.G.D. Wijngaarden (Yosha)
Wijngaarden
Yosha
aut
author
Why do creatives and artists have the tendency to flock together, and what do they draw from such co-location?
This dissertation explores whether and how the location of a creative entrepreneur and artist may contribute to his or her innovative capabilities.
Erasmus University Rotterdam
2019-12-12
en
English
creative industries
innovation
place
co-working spaces
creative labour
Spaces of co-working: Situating innovation in the creative industries
text
dissertation
oai:repub.eur.nl:135291
2024-03-01T14:19:07Z
http://hdl.handle.net/1765/135291
hdl:1765/135291
urn:NBN:nl:ui:15-1765/135291
978-94-6361-516-7
http://hdl.handle.net/1765/135291
https://repub.eur.nl/pub/135291/stefan-roobol-proefschrift-volledig.pdf
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S.J. Roobol (Stefan)
Roobol
Stefan
aut
author
The use of alpha particles irradiation in clinical practice has gained interest in the past years,
for example with the advance of radionuclide therapy. The lack of affordable and easily accessible irradiation systems to study the cell biological impact of alpha particles hampers broad
investigation. Here we present a novel alpha particle irradiation set-up for uniform irradiation
of cell cultures. By combining a small alpha emitting source and a computer-directed movement stage, we established a new alpha particle irradiation method allowing more advanced
biological assays, including large-field local alpha particle irradiation and cell survival assays.
In addition, this protocol uses cell culture on glass cover-slips which allows more advanced
microscopy, such as super-resolution imaging, for in-depth analysis of the DNA damage caused
by alpha particles. This novel irradiation set-up provides the possibility to perform reproducible, uniform and directed alpha particle irradiation to investigate the impact of alpha radiation
on the cellular level.
Erasmus University Rotterdam
2021-03-09
en
English
alpha particle
irradiation
microscopy
DSB
53BP1
DNA damage
FNTD
dosimetry
external irradiation
Ionizing Radiation Quality and Dose Effects on DNA Double Strand Break Repai
text
dissertation
oai:repub.eur.nl:135290
2024-03-01T14:18:10Z
http://hdl.handle.net/1765/135290
hdl:1765/135290
urn:NBN:nl:ui:15-1765/135290
978-94-6361-518-1
http://hdl.handle.net/1765/135290
https://repub.eur.nl/pub/135290/sadaf-oliai-araghi.pdf
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Department of Epidemiology
dgg
degree grantor
Department of Epidemiology
sht
supporting host
S. Oliai Araghi (Sadaf)
Oliai Araghi
Sadaf
aut
author
Erasmus University Rotterdam
2021-03-17
en
English
B-vitamins
Folic acid
Vitamin B12
(colorectal)cancer
Bone Mass Density
Trabecular Bone Score
Body Mass Index
Fat Mass Index
Calcium
Vitamin D
B-vitaminen
Foliumzuur
Vitamine B12
(darm)kanker
Botgezondheid
Vetmassa
BMI
Calcium
Vitamine D
Micronutrients and Health in Older Population: Friend or Foe?
text
dissertation
oai:repub.eur.nl:133040
2024-03-01T14:17:47Z
http://hdl.handle.net/1765/133040
hdl:1765/133040
urn:NBN:nl:ui:15-1765/133040
978-94-6361-489-4
http://hdl.handle.net/1765/133040
https://repub.eur.nl/pub/133040/Ronald-Booij-proefschrift-compleet-definitief.pdf
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R. Booij (Ronald)
Booij
Ronald
aut
author
Optimization of a computed tomography (CT) exam can be challenging, as there is a wide variety in patient characteristics, continuously emerging technologies and the increase of the number of interrelated acquisition and reconstruction parameters to be adjusted. Fortunately, optimization can be achieved with a “knowledgeable” CT scanner by deploying smart technologies and by merging of knowledge obtained by man and machine.
Erasmus University Rotterdam
2021-02-23
en
English
Computertomografie
Stralingsdosis
Beeldkwaliteit
Kunstmatige intelligentie
Technologische innovaties
Positionering (van een patiënt in een CT-scanner)
Data acquisitie
Beeldreconstructie in CT
Optimalisatie en nauwkeurigheid
3D-camera
Computed Tomography
Radiation dose
Image quality
Artificial intelligence
Technological innovations
Positioning (of a patient in a CT scanner)
Patient scanning
Image reconstruction in CT
Optimization and accuracy
The “Knowledgeable” CT Scanner: Optimization by technological advancements
text
dissertation
oai:repub.eur.nl:78323
2024-02-22T17:11:45Z
http://hdl.handle.net/1765/78323
hdl:1765/78323
urn:NBN:nl:ui:15-1765/78323
http://hdl.handle.net/1765/78323
https://repub.eur.nl/pub/78323/Quick-Start-Guide-NCA-4.0.0-February-2024.pdf
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Rotterdam School of Management (RSM), Erasmus University
sht
supporting host
Department of Technology and Operations Management
sht
supporting host
J. Dul (Jan)
Dul
Jan
aut
author
Necessary Condition Analysis (NCA) is an approach and data analysis technique for identifying necessary conditions in datasets. It can complement traditional regression-based data analysis as well as methods like QCA (see [the NCA website](https://www.erim.nl/nca) for more information on NCA). This guide helps a novice user without knowledge of R or NCA to install the free R and NCA software on the user’s computer and to perform an NCA analysis within 15 minutes. The main instructions are:
I. Install R
II. Install NCA
III. Load data
IV. Run NCA.
Details of the method can be found in:
- Dul, J. (2016) Necessary Condition Analysis (NCA). Logic and Methodology of 'Necessary but not Sufficient' causality. *Organizational Research Methods* 19(1), 10-52. [Sage](https://journals.sagepub.com/doi/pdf/10.1177/1094428115584005)
- Dul, J. (2020), *Conducting Necessary Condition Analysis*, Sage Publications, ISBN: 9781526460141. [Sage](https://uk.sagepub.com/en-gb/eur/conducting-necessary-condition-analysis-for-business-and-management-students/book262898)
- Dul, J., van der Laan, E., & Kuik, R. (2020). A statistical significance test for Necessary Condition Analysis. *Organizational Research Methods*, 23(2), 385-395.
[Sage](https://journals.sagepub.com/doi/10.1177/1094428118795272)
2024-02-16
en
English
software
R package
manual
data analysis
Necessary Condition Analysis (NCA) with R (version 4.0.0)
A quick start guide (16 February 2024)
text
booklet
071433015
oai:repub.eur.nl:137181
2024-02-19T13:42:32Z
oai:repub.eur.nl:137173
2024-02-14T14:19:37Z
http://hdl.handle.net/1765/137173
hdl:1765/137173
urn:NBN:nl:ui:15-1765/137173
http://hdl.handle.net/1765/137173
https://repub.eur.nl/pub/137173/Free Teaching Case
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Tsitse (Irene)
Tsitse
Irene
aut
author
Hsu (Katty)
Hsu
Katty
aut
author
Rosendahl Huber (Laura)
Rosendahl Huber
Laura
aut
author
Geerke Versteeg and Yvette Watson established the online platform The 2B Collective to immerse users in a gamified environment, teaching them about climate neutrality, circularity, and inclusivity. With a mature product, a new business model, and a committed team, the most recent financial results bolstered their confidence in scaling the venture. However, limited financial resources posed a challenge. Investor discussions revealed a focus on short-term returns rather than long-term social impact, compounded by post-pandemic market instability. This case is about Geerke and Yvette, both passionate about sustainability, and how they navigate challenges as female entrepreneurs in a male-dominated industry, while trying to stay true to their mission, values, and identity.
RSM Case Development Centre
9816
2023-10-04
en
English
Social enterprise
Social entrepreneurship
startup
female
women
financing
investment
human resources
SDG
SHE LEADS: Navigating the Funding Landscape for Female Social Entrepreneurs
text
caseStudy
oai:repub.eur.nl:137076
2024-02-12T12:10:43Z
http://hdl.handle.net/1765/137076
hdl:1765/137076
urn:NBN:nl:ui:15-1765/137076
978-90-6490-142-3
http://hdl.handle.net/1765/137076
https://repub.eur.nl/pub/137076/elyse-mills-final-phd-dissertation.pdf
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E.N. Mills (Elyse)
Mills
Elyse
aut
author
Erasmus University Rotterdam
2021-12-21
en
English
Transnational movements
fishers' movements
civil society
small-scale fisheries
food politics
climate change
political spaces
resistance
political economy
transnationale bewegingen
vissersbewegingen
burgermaatschappij
kleinschalige visserij
voedsel politiek
klimaatverandering
politieke arena's
verzetten
politieke economie
Transnational Fishers’ Movements and the Politics of Global Fisheries
text
dissertation
oai:repub.eur.nl:137162
2024-02-11T13:27:23Z
http://hdl.handle.net/1765/137162
hdl:1765/137162
urn:NBN:nl:ui:15-1765/137162
http://hdl.handle.net/1765/137162
https://repub.eur.nl/pub/137162/ERS-2023-005-LIS_v1.pdf
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born digital
Erasmus Research Institute of Management
sht
supporting host
M.C. Schippers (Michaéla)
Schippers
Michaéla
aut
author
E.M. de Jong (Elisabeth)
Jong
Elisabeth
aut
author
D.C. Rus (Diana)
Rus
Diana
aut
author
H. Rommers (Huib)
Rommers
Huib
aut
author
The Covid-19 crisis and measures have created an extraordinary situation that has affected most
people around the globe. Adapting to and coping with this unpredictable situation has proven
challenging for many. Apart from the direct effects such as a loss of income, normalcy, and
postponed healthcare, many people have experienced a loss of meaning in life, negatively affecting
their mental health and well-being. This has led many people to experience a downward spiral of
negative emotions, prompting immediate, survival-oriented behaviors and learned helplessness.
An effective way to counteract this is to restore a sense of autonomy by writing about making the
world a better place. This can be achieved by letting people reflect on an ideal world free of
constraints and contrasting this with the idea of the world that will come to pass if nothing changes.
Prior research in the field of positive psychology has shown that brief interventions can help
counteract many of the aforementioned negative consequences and even aid in developing a more
positive future outlook that individuals act upon. In this paper, we highlight an intervention, that
seems especially promising in this respect: Letters to the future. Writing about how and when one
will contribute to this ideal future, is key in ensuring that this comes a step closer to becoming
reality. Acting upon dreams and plans can also have real-world positive consequences. In sum,
based on positive psychology, goal-setting, life-crafting, and mindset theory, we propose an
intervention that offers ways to increase positive emotions, enhance social support, increase self-
transcendence, and action repertoire, and potentially kickstart societal change. As this intervention
can be done online and is scalable, we propose to use the intervention on a wide scale to improve
mental health and well-being worldwide, and at the same time make the world a better place.
ERIM report series research in management Erasmus Research Institute of Management
12556
1566-5283
ERIM Report Series Research in Management
2
ERS-2023-005-LIS
2023-02-28
en
English
Letters to the future
Life crafting
Future world crafting
Positive Psychology intervention
COVID-19 crisis
Abundance versus scarcity mindset
Self-transcedence
Positive ripple effects
Shaping ideal futures: Writing a letter to the future
text
researchPaper
160992486
298674793
oai:repub.eur.nl:137175
2024-02-09T13:02:11Z
oai:repub.eur.nl:137176
2024-02-09T12:56:51Z
oai:repub.eur.nl:131561
2024-01-27T10:05:38Z
http://hdl.handle.net/1765/131561
hdl:1765/131561
urn:NBN:nl:ui:15-1765/131561
http://hdl.handle.net/1765/131561
S.J. Keulen (Sjoerd)
Keulen
Sjoerd
aut
author
2020-01-01
en
English
Een ijzeren kanselier op Justitie: secretaris-generaal Albert Mulder (1965-1978)
text
bookChapter
oai:repub.eur.nl:116529
2024-01-22T23:18:57Z
http://hdl.handle.net/1765/116529
hdl:1765/116529
urn:NBN:nl:ui:15-1765/116529
doi:10.1111/joms.12514
http://hdl.handle.net/1765/116529
Department of Strategic Management and Entrepreneurship
sht
supporting host
P. Vishwanathan (Pushpika)
Vishwanathan
Pushpika
aut
author
J. van Oosterhout (Hans)
Oosterhout
Hans
aut
author
Duran Solis, P.A.
Duran Solis
P.A.
aut
author
M. van Essen (Marc)
Essen
Marc
aut
author
This study develops the concept of Strategic Corporate Social Responsibility (Strategic CSR)
by meta
-analyzing the available empirical evidence on the relationship between CSR and
corporate financial performance (CFP). Using meta
-analytic structural equation modeling on
effect size data from 344 primary studies, our study documents four empirical mechanisms
explaining how CSR positively affects CFP: by 1) enhancing firm reputation, 2) increasing
stakeholder reciprocation, 3) mitigating firm risk, and 4) strengthening innovation capacity.
We propose these four mechanisms to identify four causally relevant attributes that allow us
to conceptually distinguish Strategic CSR from CSR more generally. Our findings indicate that the four mechanisms combined explain 20 percent of the CSR
-CFP relationship,
suggesting that considerable room remains for future empirical research
. The development of
an empirically informed, causal conceptualization of Strategic CSR respond
s to a long
-heard
call for better
-specified concepts in empirical CSR research.
Journal of Management Studies
11239
00222380
Accepted
2019-05-21
en
English
Concept FormatiCorporate Social Responsibility
Financial Performance
Meta-Analysis
Strategy
.
Strategic CSR: a concept building meta-analysis
text
article
142124613
oai:repub.eur.nl:113366
2024-01-15T11:06:12Z
http://hdl.handle.net/1765/113366
hdl:1765/113366
urn:NBN:nl:ui:15-1765/113366
http://hdl.handle.net/1765/113366
https://repub.eur.nl/pub/113366/Repub_113366.pdf
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born digital
Department of General Practice
sht
supporting host
Health Services Management & Organisation (HSMO)
sht
supporting host
P. Jellema (Petra)
Jellema
Petra
aut
author
N. de la Rambelje (Nadiyah)
aut
author
M.C. de Bruijne (Martine)
Bruijne
Martine
aut
author
J.W.M. Weggelaar-Jansen (Anne Marie)
Weggelaar-Jansen
Anne Marie
aut
author
M. Visser (Mildred)
Visser
Mildred
aut
author
De doelstelling van het onderzoek luidde: het onderzoeken van een effectieve actiegerichte presentatie van ziekenhuisbrede kwaliteitsindicatoren op een executive dashboard voor de Raad van Bestuur (en haar ondersteuners), ten behoeve van signaleren, controleren, verantwoorden, dialoog voeren, verbeteren of benchmark vergelijking tussen ziekenhuizen.
Het onderzoek bouwde voort op eerder uitgevoerd onderzoek in het programma Sturen op Kwaliteit en de daarin ontwikkelde indicatoren uit de deelprojecten.
2018-11-29
nl
Dutch
HANDLEIDING VORMGEVING van DASHBOARDS met kwaliteitsinformatie
text
researchPaper
oai:repub.eur.nl:129666
2024-01-15T11:05:36Z
http://hdl.handle.net/1765/129666
hdl:1765/129666
urn:NBN:nl:ui:15-1765/129666
http://hdl.handle.net/1765/129666
https://repub.eur.nl/pub/129666/e-Health-waardenmodel-rapport.def.pdf
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J.W.M. Weggelaar-Jansen (Anne Marie)
Weggelaar-Jansen
Anne Marie
aut
author
M. de Mul (Marleen)
Mul
Marleen
aut
author
R. Auragh
Auragh
R.
aut
author
S. Sülz (Sandra)
Sülz
Sandra
aut
author
H.J. van Elten (Hilco)
Elten
Hilco
aut
author
K. Cranen
Cranen
K.
aut
author
T. Creton
Creton
T.
aut
author
M. Askari (Marjan)
Askari
Marjan
aut
author
R. Huijsman (Robbert)
Huijsman
Robbert
aut
author
M. Visser (Mildred)
Visser
Mildred
aut
author
Voor de structurele financiering van e-health is het belangrijk om de toegevoegde waarde hiervan inzichtelijk te maken. Dat gebeurt op dit moment op verschillende manieren. Soms kijkt men alleen naar de financiële opbrengsten voor de zorginstelling of leverancier, soms wordt ook de maatschappelijke waarde meegenomen. In het onderzoeksproject Waardemodel e-health ontwikkelde we een integraal model dat alle kosten en inspanningen afzet tegen alle baten en opbrengsten, voor verschillende stakeholders.
In het rapport wordt een overzicht gegeven van de verschillende methoden om waarde te bepalen, met uitleg over het doel, voor- en nadelen van iedere methode. Daarnaast wordt het model uitgelegd en een handleiding gegeven hoe je met het model kunt werken.
2020-04-01
en
English
e-health waardenmodel
text
report
298684462
288254252
073610232
oai:repub.eur.nl:115408
2024-01-10T12:34:21Z
http://hdl.handle.net/1765/115408
hdl:1765/115408
urn:NBN:nl:ui:15-1765/115408
978-94-93014-51-0
http://hdl.handle.net/1765/115408
https://repub.eur.nl/pub/115408/Dissertation_F.Wienholz-Embargo-Chapters-.pdf
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F. Wienholz (Franziska)
Wienholz
Franziska
aut
author
Many aspects of TC-NER have been described since the discovery of this
versatile DNA damage repair pathway three decades ago [123]. However,
many crucial questions regarding its exact molecular mechanism and the
manner in which it deals with different types of lesions remain
unanswered [31].
To further unravel the TC-NER mechanism, sensitive techniques that can
specifically measure TC-NER activity would be of great value. In Chapter 2
the development of a new, single-cell assay that can quantify TC-NER
activity is described. This immunofluorescence-based method allows the
direct measurement of TC-NER activity in an user-friendly manner.
Furthermore, this sensitive assay not only enables the measurements of
TC-NER and GG-NER activity on low, physiological relevant, UV-C doses (2
J/m2), but also allows detection and quantification of the activity of other
excision repair pathways.
Thus far, the exact mechanism how UVSSA is recruited to the TC-NER
complex remains elusive. Therefore, we studied the accumulation of
UVSSA on UV-C induced DNA damage in Chapter 3. Using live cell
microscopy, we showed that UVSSA is recruited to DNA damage in a CSA
and CSB independent manner. We further showed, using specific UVSSA
deletion mutants that the DUF2043 domain is important for its
recruitment to UV-induced DNA damage. To identify factors involved in
the recruitment of UVSSA to DNA damage, a quantitative mass
spectrometry approach was used to reveal proteins that specifically
interact with the DUF2043 domain. With this approach we identified the
FACT subunit Spt16 as a novel UVSSA interactor and follow-up studies
indicated that Spt16 is involved in the recruitment of UVSSA to sites of
DNA damage.
As UVSSA is hypothesised to be involved in the response to both UV and
oxidative induced DNA damage, in Chapter 4 we used quantitative
interaction proteomics to identify UVSSA interactions that were
specifically induced following UV-C or H2O2 induced DNA damage. In this
chapter we describe the damage-specific UVSSA interaction partners,
discuss their potential roles and propose that UVSSA might have different
functions following UV or oxidative DNA damage.
In Chapter 5, the function of the TC-NER factor CSB during the repair of
oxidative damage was analysed. Live cell imaging studies indicated that
the recruitment of XRCC1 to oxidative lesions is dependent on functional
CSB and active transcription, whereas recruitment of the BER-initiating
glycosylase OGG1 does not require transcription or CSB. Based on our data
we propose a model in which CSB facilitates XRCC1 recruitment to RNA
polymerase II complexes stalled at BER-intermediates. These results
further establish the importance of CSB in BER.
In Chapter 6 we discuss the main findings of the experimental work
described in this thesis and provide future directions to study the role and
molecular function of TC-NER factors in the repair of different types of
DNA damage.
Erasmus University Rotterdam
2019-03-14
en
English
DNA DAMAGE REPAIR
TC-NER
OXIDATIVE DNA DAMAGE
UV-INDUCED
DNA DAMAGE
COCKAYNE SYNDROME
UV-SENSITIVITY SYNDROME
Focusing on the Versatile Transcription-Coupled DNA Repair Pathway
text
dissertation
oai:repub.eur.nl:137172
2023-12-21T13:54:38Z
oai:repub.eur.nl:96147
2023-12-19T12:58:36Z
oai:repub.eur.nl:96145
2023-12-19T12:58:36Z
oai:repub.eur.nl:96144
2023-12-19T12:58:36Z
oai:repub.eur.nl:96143
2023-12-19T12:58:36Z
oai:repub.eur.nl:96142
2023-12-19T12:58:36Z
oai:repub.eur.nl:96141
2023-12-19T12:58:36Z
oai:repub.eur.nl:96140
2023-12-19T12:58:36Z
oai:repub.eur.nl:9614
2023-12-19T12:58:36Z
http://hdl.handle.net/1765/9614
hdl:1765/9614
urn:NBN:nl:ui:15-1765/9614
http://hdl.handle.net/1765/9614
https://repub.eur.nl/pub/9614/11254819.pdf
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Erasmus MC: University Medical Center Rotterdam
sht
supporting host
Department of Pediatrics
sht
supporting host
Q. Jobsis (Quirijn)
Jobsis
Quirijn
aut
author
R.H. Raatgeep (Rolien)
Raatgeep
Rolien
aut
author
W.C.J. Hop (Wim)
Hop
Wim
aut
author
J.C. de Jongste (Johan)
Jongste
Johan
aut
author
BACKGROUND: The aim of this study was to validate exhaled nitric oxide
(eNO) values obtained with an alternative off line, single breath, low
flow balloon sampling method against on line sampling according to ERS and
ATS guidelines in children who could perform both methods. METHODS: One
hundred and twenty seven white children of median age 14.1 years, all
pupils of a secondary school, participated in the study. They performed
the two different sampling techniques at three different flows of 50, 100,
150 ml/s. Additional measurements were done in random subgroups to
determine the influence of the dead space air on eNO values obtained off
line by excluding the first 220 ml of exhaled air. All children completed
a questionnaire on respiratory and allergic disorders and underwent
spirometric tests. RESULTS: The off line eNO values were significantly
higher than the on line values at all flows. At 50 ml/s the geometric mean
(SE) off line eNO was 18.7 (1.1) ppb and the on line eNO was 15.1 (1.1)
ppb (p<0.0001). However, when dead space air was discarded, off line and
on line values were similar: at 50 ml/s off line eNO was 17.7 (1.0) ppb
and on line eNO 16.0 (1.2) ppb. There was a good agreement between off
line eNO values without dead space air and on line eNO: for 50 ml/s the
mean on/off line ratio was 0.95 (95% agreement limits 0.63 to 1.27). The
off line eNO level at 50 ml/s in 80 children with negative questionnaires
for asthma, rhinitis, and eczema was 13.6 (1.0) ppb compared with 33.3
(1.1) ppb in the remaining children with positive questionnaires on asthma
and allergy and/or recent symptoms of cold (p<0.0001). CONCLUSIONS: In
children, off line assessment of eNO using constant low flow sampling and
excluding dead space air is feasible and produces similar results as on
line assessment with the same exhalation flow rate. Both sampling methods
are sufficiently sensitive to differentiate between groups of otherwise
healthy school children with and without self-reported asthma, allergy,
and/or colds. We propose that, for off line sampling, similar low flow
rates should be used as are recommended for on line measurements.
Thorax: an international journal of respiratory medicine
10220
00406376
2001-01-01
en
English
Adolescent
Breath Tests/*methods
Child
Female
Forced Expiratory Volume/physiology
Humans
Hypersensitivity/physiopathology
Male
Nitric Oxide/*analysis
Reference Values
Reproducibility of Results
Research Support
Non-U.S. Gov't
Respiration Disorders/*physiopathology
Vital Capacity/physiology
Controlled low flow off line sampling of exhaled nitric oxide in children
text
article
070835977
073184586
oai:repub.eur.nl:96139
2023-12-19T12:58:36Z
http://hdl.handle.net/1765/96139
hdl:1765/96139
urn:NBN:nl:ui:15-1765/96139
doi:10.1016/j.hpb.2016.01.515
http://hdl.handle.net/1765/96139
Department of Surgery
sht
supporting host
L.G.M. van der Geest (Lydia G.M.)
van der Geest
Lydia G.M.
aut
author
L.B. van Rijssen (Lennart B.)
van Rijssen
Lennart B.
aut
author
I.Q. Molenaar (I. Quintus)
Molenaar
I. Quintus
aut
author
I.H.J.T. de Hingh (Ignace)
Hingh
Ignace
aut
author
B. Groot Koerkamp (Bas)
Groot Koerkamp
Bas
aut
author
O.R.C. Busch (Olivier)
Busch
Olivier
aut
author
V.E.P.P. Lemmens (Valery)
Lemmens
Valery
aut
author
M.G. Besselink (Marc)
Besselink
Marc
aut
author
Background: Volume-outcome relationships in pancreatic surgery are well established, but an optimal volume remains to be determined. Studies analyzing outcomes in volume categories exceeding 20 procedures annually are lacking. Study design: A consecutive 3420 patients underwent PD for primary pancreatic or periampullary carcinoma (2005-2013) and were registered in the Netherlands Cancer Registry. Relationships between hospital volume (<5, 5-19, 20-39 and >40 PDs/year) and mortality and survival were explored. Results: There was a non-significant decrease in 90-day mortality from 8.1 to 6.7% during the study period (p = 0.23). Ninety-day mortality was 9.7% in centers performing <5 PDs/year (n = 185 patients), 8.9% for 5-19 PDs/year (n = 1432), 7.3% for 20-39 PDs/year (n = 240) and 4.3% for >40 PDs/year (n = 562, p = 0.004). Within volume categories, 90-day mortality did not change over time. After adjustment for confounding factors, significantly lower mortality was found in the >40 category compared to 20-39 PDs/year (OR = 1.72 (1.08-2.74)). Overall survival adjusted for confounding factors was better in the >40 category compared to categories under 20 PDs/year: HR (>40 vs 5-19/year) = 1.24 (1.09-1.42). In the >40 category significantly more patients received adjuvant chemotherapy and had >10 lymph nodes retrieved compared to lower volume categories. Conclusions: Volume-outcome relationships in pancreatic surgery persist in centers performing >40 PDs annually, regarding both mortality and survival. The volume plateau for pancreatic surgery has yet to be determined.
HPB
13201
1365182X
18
4
317
324
2016-01-01
en
English
Volume-outcome relationships in pancreatoduodenectomy for cancer
text
article
298677423
304786152
oai:repub.eur.nl:96138
2023-12-19T12:58:36Z
http://hdl.handle.net/1765/96138
hdl:1765/96138
urn:NBN:nl:ui:15-1765/96138
doi:10.1093/eurheartj/ehv500
http://hdl.handle.net/1765/96138
https://repub.eur.nl/pub/96138/REPUB_96138-OA.pdf
application/pdf
Filesize: 794318 bytes
born digital
Erasmus MC: University Medical Center Rotterdam
sht
supporting host
M. Sabate (Manel)
Sabate
Manel
aut
author
S.W. Windecker (Stephan)
Windecker
Stephan
aut
author
A. Iiguez (Andres)
Iiguez
Andres
aut
author
Okkels-Jensen, L. (Lisette)
Okkels-Jensen
L. (Lisette)
aut
author
A. Cequier (Angel)
Cequier
Angel
aut
author
S. Brugaletta (Salvatore)
Brugaletta
Salvatore
aut
author
S.H. Hofma (Sjoerd)
Hofma
Sjoerd
aut
author
L. Räber (Lorenz)
Räber
Lorenz
aut
author
Christiansen, E.H. (Evald Høi)
Christiansen
E.H. (Evald Høi)
aut
author
M.J. Suttorp (Maarten)
Suttorp
Maarten
aut
author
T. Pilgrim (Thomas)
Pilgrim
Thomas
aut
author
G.A. van Es (Gerrit Anne)
Es
Gerrit Anne
aut
author
Y. Sotomi (Yohei)
Sotomi
Yohei
aut
author
H.M. Garcia-Garcia (Hector)
Garcia-Garcia
Hector
aut
author
Y. Onuma (Yoshinobu)
Onuma
Yoshinobu
aut
author
P.W.J.C. Serruys (Patrick)
Serruys
Patrick
aut
author
Aims: Patients with ST-segment elevation myocardial infarction (STEMI) feature thrombus-rich lesions with large necrotic core, which are usually associated with delayed arterial healing and impaired stent-related outcomes. The use of bioresorbable vascular scaffolds (Absorb) has the potential to overcome these limitations owing to restoration of native vessel lumen and physiology at long term. The purpose of this randomized trial was to compare the arterial healing response at short term, as a surrogate for safety and efficacy, between the Absorb and the metallic everolimus-eluting stent (EES) in patients with STEMI. Methods and results: ABSORB-STEMI TROFI II was a multicentre, single-blind, non-inferiority, randomized controlled trial. Patients with STEMI who underwent primary percutaneous coronary intervention were randomly allocated 1:1 to treatment with the Absorb or EES. The primary endpoint was the 6-month optical frequency domain imaging healing score (HS) based on the presence of uncovered and/or malapposed stent struts and intraluminal filling defects. Main secondary endpoint included the device-oriented composite endpoint (DOCE) according to the Academic Research Consortium definition. Between 06 January 2014 and 21 September 2014, 191 patients (Absorb [n + 95] or EES [n = 96]; mean age 58.6 years old; 17.8% females) were enrolled at eight centres. At 6 months, HS was lower in the Absorb arm when compared with EES arm [1.74 (2.39) vs. 2.80 (4.44); difference (90% CI) 21.06 (21.96, 20.16); Pnon-inferiority <0.001]. Device-oriented composite endpoint was also comparably low between groups (1.1% Absorb vs. 0% EES). One case of definite subacute stent thrombosis occurred in the Absorb arm (1.1% vs. 0% EES; P = ns). Conclusion: Stenting of culprit lesions with Absorb in the setting of STEMI resulted in a nearly complete arterial healing which was comparable with that of metallic EES at 6 months. These findings provide the basis for further exploration in clinically oriented outcome trials.
European Heart Journal
11747
0195668X
37
3
229
240
2016-01-01
en
English
Bioresorbable scaffold
Optical coherence tomography
Randomized control study
ST elevation myocardial infarction
Everolimus-eluting bioresorbable stent vs. durable polymer everolimus-eluting metallic stent in patients with ST-segment elevation myocardial infarction: Results of the randomized ABSORB ST-segment elevation myocardial infarction-TROFI II trial
text
article
075008602
374719659
298677210
oai:repub.eur.nl:96137
2023-12-19T12:58:36Z
oai:repub.eur.nl:96136
2023-12-19T12:58:36Z
oai:repub.eur.nl:96135
2023-12-19T12:58:36Z
oai:repub.eur.nl:96134
2023-12-19T12:58:36Z
http://hdl.handle.net/1765/96134
hdl:1765/96134
urn:NBN:nl:ui:15-1765/96134
doi:10.1002/cam4.921
http://hdl.handle.net/1765/96134
https://repub.eur.nl/pub/96134/REPUB_96134-OA.pdf
application/pdf
Filesize: 223194 bytes
born digital
Department of Public Health
sht
supporting host
Bakens, M.J. (Maikel J.)
Bakens
M.J. (Maikel J.)
aut
author
L.G.M. van der Geest (Lydia G.M.)
van der Geest
Lydia G.M.
aut
author
M. van Putten (Margreet)
Putten
Margreet
aut
author
H.W.M. van Laarhoven (Hanneke)
Laarhoven
Hanneke
aut
author
G.J.M. Creemers (Geert-Jan)
Creemers
Geert-Jan
aut
author
M.G. Besselink (Marc)
Besselink
Marc
aut
author
V.E.P.P. Lemmens (Valery)
Lemmens
Valery
aut
author
I.H.J.T. de Hingh (Ignace)
Hingh
Ignace
aut
author
Adjuvant chemotherapy after pancreatoduodenectomy for pancreatic cancer is currently considered standard of care. In this nationwide study, we investigated which characteristics determine the likelihood of receiving adjuvant chemotherapy and its effect on overall survival. The data were obtained from the Netherlands Cancer Registry. All patients alive 90 days after pancreatoduodenectomy for M0-pancreatic cancer between 2008 and 2013 in the Netherlands were included in this study. The likelihood to receive adjuvant chemotherapy was analyzed by multilevel logistic regression analysis and differences in time-to-first-chemotherapy were tested for significance by Mann–Whitney U test. Overall survival was assessed by Kaplan–Meier method and Cox regression analysis. Of the 1195 patients undergoing a pancreatoduodenectomy for pancreatic cancer, 642 (54%) patients received adjuvant chemotherapy. Proportions differed significantly between the 19 pancreatic centers, ranging from 26% to 74% (P < 0.001). Median time-to-first-chemotherapy was 6.7 weeks and did not differ between centers. Patients with a higher tumor stage, younger age, and diagnosed more recently were more likely to receive adjuvant treatment. The 5-year overall survival was significantly prolonged in patients treated with adjuvant chemotherapy—23% versus 17%, log-rank = 0.01. In Cox regression analysis, treatment with adjuvant chemotherapy significantly prolonged survival compared with treatment without adjuvant chemotherapy. The finding that elderly patients and patients with a low tumor stage are less likely to undergo treatment needs further attention, especially since adjuvant treatment is known to prolong survival in most of these patients.
2016-10-01
en
English
Adjuvant chemotherapy
pancreatic cancer
treatment
The use of adjuvant chemotherapy for pancreatic cancer varies widely between hospitals: a nationwide population-based analysis
text
article
304786152
oai:repub.eur.nl:96133
2023-12-19T12:58:36Z
oai:repub.eur.nl:96132
2023-12-19T12:58:36Z
http://hdl.handle.net/1765/96132
hdl:1765/96132
urn:NBN:nl:ui:15-1765/96132
doi:10.1007/s10654-016-0195-x
http://hdl.handle.net/1765/96132
https://repub.eur.nl/pub/96132/REPUB_96132-OA.pdf
application/pdf
Filesize: 336475 bytes
born digital
Department of Epidemiology
sht
supporting host
A. Dehghan (Abbas)
Dehghan
Abbas
aut
author
European Journal of Epidemiology
10567
03932990
31
8
715
716
2016-08-01
en
English
Mass spectrometry in epidemiological studies: What are the key considerations?
text
article
326078789
oai:repub.eur.nl:96131
2023-12-19T12:58:36Z
oai:repub.eur.nl:96130
2023-12-19T12:58:36Z
oai:repub.eur.nl:9613
2023-12-19T12:58:36Z
http://hdl.handle.net/1765/9613
hdl:1765/9613
urn:NBN:nl:ui:15-1765/9613
http://hdl.handle.net/1765/9613
https://repub.eur.nl/pub/9613/11248740.pdf
application/pdf
Filesize: 943929 bytes
born digital
Erasmus MC: University Medical Center Rotterdam
sht
supporting host
F.E. de Jongh (Felix)
Jongh
Felix
aut
author
A.C. Jobsis
Jobsis
A.C.
aut
author
J.W.F. Elte (Jan Willem)
Elte
Jan Willem
aut
author
OBJECTIVE: Non-thyroidal illness (NTI) is associated with alterations in
thyroid hormone metabolism. Whether morphological changes of the thyroid
gland accompany NTI is unknown. The aim of the present study was to
describe thyroid morphology in patients with lethal non-thyroidal disease.
DESIGN: In an autopsy study 267 cases have been examined. METHODS:
Clinical data were obtained from medical records. Subjects were patients
with chronic disease (group A), intensive care patients (group B) or
persons who had died suddenly without pre-existing illnesses (group C).
Patients (n = 93) who did not fit into one of these categories and
subjects with pre-existing thyroid disorders were excluded. Thyroid
histology was assessed semi-quantitatively: grade I <25%, grade II 25--50%
or grade III >75% occupation of the thyroid gland by follicles with a
diameter <200 microm. RESULTS: Mean thyroid weight was 19.9 g in group A
(n=75, age 19--96 (median 75) years, 48 males); 25.7 g in group B (n=64,
age 24--93 (median 69) years, 43 males); and 26.0 g in group C (n=35, age
31--89 (median 69) years, 22 males) (P<0.0005, A vs B/C). Grade I thyroid
histology was present in 6 out of 75 patients with chronic illness, in 3
out of 64 intensive care patients and in 33 out of 35 sudden-death
subjects. Grade III thyroid histology occurred in 30 out of 75 chronically
ill patients, in 17 out of 64 intensive care patients and in 0 out of 35
sudden-death subjects (P<0.0005, C vs A/B). CONCLUSIONS: NTI is associated
with reduced thyroid follicular size that is accompanied by lower thyroid
weight in chronically ill patients but not significantly in intensive care
patients.
European Journal of Endocrinology
10557
08044643
2001-01-01
en
English
*Disease
Acute Disease
Adult
Aged
Aged, 80 and over
Autopsy
Chronic Disease
Female
Humans
Intensive Care
Male
Middle aged
Organ Size
Thyroid Gland/metabolism/*pathology
Thyroid morphology in lethal non-thyroidal illness: a post-mortem study
text
article
oai:repub.eur.nl:96129
2023-12-19T12:58:36Z
oai:repub.eur.nl:96128
2023-12-19T12:58:36Z
http://hdl.handle.net/1765/96128
hdl:1765/96128
urn:NBN:nl:ui:15-1765/96128
doi:10.1016/j.ebiom.2016.07.015
info:eu-repo/grantAgreement/EC/FP7/270259
http://hdl.handle.net/1765/96128
https://repub.eur.nl/pub/96128/REPUB_96128-OA.pdf
application/pdf
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Department of Public Health
sht
supporting host
M. Oresic (Matej)
Oresic
Matej
aut
author
Posti, J.P. (Jussi P.)
Posti
J.P. (Jussi P.)
aut
author
Kamstrup-Nielsen, M.H. (Maja H.)
Kamstrup-Nielsen
M.H. (Maja H.)
aut
author
Takala, R.S.K. (Riikka S.K.)
Takala
R.S.K. (Riikka S.K.)
aut
author
H.F. Lingsma (Hester)
Lingsma
Hester
aut
author
Mattila, I. (Ismo)
Mattila
I. (Ismo)
aut
author
Jäntti, S. (Sirkku)
Jäntti
S. (Sirkku)
aut
author
A. Katila (Ari)
Katila
Ari
aut
author
K.L.H. Carpenter (Keri L.H.)
Carpenter
Keri L.H.
aut
author
Ala-Seppälä, H. (Henna)
Ala-Seppälä
H. (Henna)
aut
author
Kyllönen, A. (Anna)
Kyllönen
A. (Anna)
aut
author
Maanpää, H.-R. (Henna-Riikka)
Maanpää
H.-R. (Henna-Riikka)
aut
author
Tallus, J. (Jussi)
Tallus
J. (Jussi)
aut
author
J.P. Coles (Jonathan P.)
Coles
Jonathan P.
aut
author
Heino, I. (Iiro)
Heino
I. (Iiro)
aut
author
J. Frantzén (Janek)
Frantzén
Janek
aut
author
P.J. Hutchinson (Peter J.)
Hutchinson
Peter J.
aut
author
D.K. Menon (David )
Menon
David
aut
author
O. Tenovuo (Olli)
Tenovuo
Olli
aut
author
Hyötyläinen, T. (Tuulia)
Hyötyläinen
T. (Tuulia)
aut
author
Traumatic brain injury (TBI) is a major cause of death and disability worldwide, especially in children and young adults. TBI is an example of a medical condition where there are still major lacks in diagnostics and outcome prediction. Here we apply comprehensive metabolic profiling of serum samples from TBI patients and controls in two independent cohorts. The discovery study included 144 TBI patients, with the samples taken at the time of hospitalization. The patients were diagnosed as severe (sTBI; n = 22), moderate (moTBI; n = 14) or mild TBI (mTBI; n = 108) according to Glasgow Coma Scale. The control group (n = 28) comprised of acute orthopedic non-brain injuries. The validation study included sTBI (n = 23), moTBI (n = 7), mTBI (n = 37) patients and controls (n = 27). We show that two medium-chain fatty acids (decanoic and octanoic acids) and sugar derivatives including 2,3-bisphosphoglyceric acid are strongly associated with severity of TBI, and most of them are also detected at high concentrations in brain microdialysates of TBI patients. Based on metabolite concentrations from TBI patients at the time of hospitalization, an algorithm was developed that accurately predicted the patient outcomes (AUC = 0.84 in validation cohort). Addition of the metabolites to the established clinical model (CRASH), comprising clinical and computed tomography data, significantly improved prediction of patient outcomes. The identified ‘TBI metabotype’ in serum, that may be indicative of disrupted blood-brain barrier, of protective physiological response and altered metabolism due to head trauma, offers a new avenue for the development of diagnostic and prognostic markers of broad spectrum of TBIs.
EBioMedicine
22348
23523964
12
118
126
2016-10-01
en
English
Biomarkers
Mass spectrometry
Metabolomics
Traumatic brain injury
Human Serum Metabolites Associate With Severity and Patient Outcomes in Traumatic Brain Injury
text
article
329804189
oai:repub.eur.nl:96127
2023-12-19T12:58:36Z
oai:repub.eur.nl:96126
2023-12-19T12:58:36Z
oai:repub.eur.nl:96125
2023-12-19T12:58:36Z
http://hdl.handle.net/1765/96125
hdl:1765/96125
urn:NBN:nl:ui:15-1765/96125
http://hdl.handle.net/1765/96125
https://repub.eur.nl/pub/96125/58-2016-6-artikel-landuyt.pdf
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Department of Child and Adolescent Psychiatry and Psychology
sht
supporting host
G. Landuyt (Goedele)
Landuyt
Goedele
aut
author
B. Dierckx (Bram)
Dierckx
Bram
aut
author
P.F.A. de Nijs (Pieter)
Nijs
Pieter
aut
author
G.C. Dieleman (Gwen)
Dieleman
Gwen
aut
author
BACKGROUND: Trichotillomania (TTM) is a psychiatric condition that first manifests itself in infancy and adolescence. If untreated, the condition can become chronic, TTM places a considerable burden on the individual patient. The condition is often linked to social isolation and the emergence of somatic and psychiatric comorbidity. Nevertheless, investment in research, particularly in the pharmacotherapeutical area, has been rather limited. AIM: To provide an overview of the phenomenology of TTM, the associated comorbidity and the therapies available for treating this underexposed child psychiatric disorder. METHOD: We searched PubMed using the the MeSH term 'trichotillomania/therapy' and located 49 relevant articles. RESULTS: We found 49 usable articles. Selective Serotonine reuptake inhibitors (SSRIS) are the most frequently prescribed drugs for the treatment of pediatric TTM, although their efficacy is not yet proven. The results of a meta-analysis of several SSRIS did not differ significantly from the results obtained with patients who had been prescribed only placebos. The efficacy of SSRIS in youths has not been studied yet. A meta-analysis of clomipramine with adult TTM patients did show a statistical difference with the control group. The efficacy of clomipramine in youths has not yet been studied. In a randomised controlled trial (RCT), treatment of adult TTM patients with olanzapine proved to be more effective than placebos. Despite this RCT and the positive results of open-label studies with pimozide and haloperidol in adults, there is no research available concerning the efficacy of antipsychotics in children and youths. In an RCT with 7-8 year-olds, cognitive behavioural therapy was found to decrease the symptoms in 75% of the participants. CONCLUSION For now there's only evidence for HRT as effective intervention in children and youths with TTM.
ACHTERGROND Trichotillomanie (ttm) is een psychiatrische aandoening die zich voor het eerst in de kindertijd en de
adolescentie manifesteert. Onbehandeld bestaat het risico op chroniciteit. ttm brengt een grote
lijdensdruk met zich mee voor de patiënt; de aandoening gaat gepaard met sociale isolatie en het
ontstaan van somatische en psychiatrische comorbiditeit. Desondanks zijn de onderzoeksinspanningen,
met name op farmacotherapeutisch gebied, nog beperkt.
DOEL Een overzicht geven van de fenomenologie van en de comorbiditeit en de behandelopties bij deze
onderbelichte kinderpsychiatrische aandoening.
METHODE Een PubMed-zoekactie met de MeSH-term ‘trichotillomania/therapy’.
RESULTATEN We vonden 49 bruikbare artikelen. Selectieve serotonineheropnameremmers (ssri’s) zijn de meest
voorgeschreven medicatie bij pediatrische ttm hoewel de werkzaamheid ervan niet is aangetoond.
Een meta-analyse van verschillende ssri’s bij volwassenen met ttm leverde geen statistisch
significant verschil op met placebo. De effectiviteit van ssri’s bij kinderen en jongeren werd nog niet
onderzocht. Een meta-analyse van de effecten van clomipramine bij volwassenen met ttm leverde
wel een statistisch significant verschil op met de controleconditie. De effectiviteit van clomipramine
bij kinderen en jongeren werd nog niet onderzocht. Olanzapine bleek in een gerandomiseerde
gecontroleerde trial (rct) bij volwassenen met ttm effectiever dan placebo. Ondanks deze rct en de
positieve resultaten van open-labelstudies met pimozide en haloperidol bij volwassenen, is er nog geen
studie gepubliceerd over de werkzaamheid van antipsychotica bij kinderen en jongeren. In een rct bij
7-18-jarigen leidde cognitieve gedragstherapie in de vorm van habit reversal therapy (hrt) bij 75% tot
vermindering van de ernst van de symptomen.
CONCLUSIE Er bestaat tot op heden op therapeutisch gebied enkel evidentie voor hrt, als werkzame interventie
bij kinderen en jongeren met ttm.
Tijdschrift voor Psychiatrie
22037
03037339
58
6
463
470
2016-06-01
en
English
Adolescent
Child
Treatment
adolescent
behandeling kind
trichotillomanie
Trichotillomania
Behandelopties bij pediatrische trichotillomanie
text
article
298679140
oai:repub.eur.nl:96124
2023-12-19T12:58:36Z
oai:repub.eur.nl:96123
2023-12-19T12:58:36Z
http://hdl.handle.net/1765/96123
hdl:1765/96123
urn:NBN:nl:ui:15-1765/96123
doi:10.1016/j.autrev.2016.07.018
http://hdl.handle.net/1765/96123
https://repub.eur.nl/pub/96123/doi
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Department of Neurology
sht
supporting host
Department of Immunology
sht
supporting host
A. van Sonderen (Agnes)
Sonderen
Agnes
aut
author
M.W.J. Schreurs (Marco)
Schreurs
Marco
aut
author
P.W. Wirtz
Wirtz
P.W.
aut
author
P.A.E. Sillevis Smitt (Peter)
Sillevis Smitt
Peter
aut
author
M.J. Titulaer (Maarten)
Titulaer
Maarten
aut
author
A wide variety of clinical syndromes has been associated with antibodies to voltage-gated potassium channels (VGKCs). Six years ago, it was discovered that patients do not truly have antibodies to potassium channels, but to associated proteins. This enabled the distinction of three VGKC-positive subgroups: anti-LGI1 patients, anti-Caspr2 patients and VGKC-positive patients lacking both antibodies. Patients with LGI1-antibodies have a limbic encephalitis, often with hyponatremia, and about half of the patients have typical faciobrachial dystonic seizures. Caspr2-antibodies cause a more variable syndrome of peripheral or central nervous system symptoms, almost exclusively affecting older males. Immunotherapy seems to be beneficial in patients with antibodies to LGI1 or Caspr2, stressing the need for early diagnosis. Half of the VGKC-positive patients lack antibodies to both LGI1 and Caspr2. This is a heterogeneous group of patients with a wide variety of clinical syndromes, raising the question whether VGKC-positivity is truly a marker of disease in these patients. Data regarding this issue are limited, but a recent study did not show any clinical relevance of VGKC-positivity in the absence of antibodies to LGI1 and Caspr2. The three VGKC-positive subgroups are essentially different, therefore, the lumping term ‘VGKC-complex antibodies’ should be abolished.
Autoimmunity Reviews
14036
15689972
15
10
970
974
2016-10-01
en
English
Antibody
Caspr2
Encephalitis
LGI1
VGKC
From VGKC to LGI1 and Caspr2 encephalitis: The evolution of a disease entity over time
text
review
298690012
oai:repub.eur.nl:96122
2023-12-19T12:58:36Z
oai:repub.eur.nl:96121
2023-12-19T12:58:36Z
oai:repub.eur.nl:96120
2023-12-19T12:58:36Z
oai:repub.eur.nl:9612
2023-12-19T12:58:36Z
http://hdl.handle.net/1765/9612
hdl:1765/9612
urn:NBN:nl:ui:15-1765/9612
http://hdl.handle.net/1765/9612
https://repub.eur.nl/pub/9612/11247866.pdf
application/pdf
Filesize: 160632 bytes
born digital
Erasmus MC: University Medical Center Rotterdam
sht
supporting host
Department of Public Health
sht
supporting host
P. Krijnen (Pieta)
Krijnen
Pieta
aut
author
C.J. Kaandorp
Kaandorp
C.J.
aut
author
E.W. Steyerberg (Ewout)
Steyerberg
Ewout
aut
author
D. van Schaardenburg (Dirkjan)
Schaardenburg
Dirkjan
aut
author
H.J. Moens
Moens
H.J.
aut
author
J.D.F. Habbema (Dik)
Habbema
Dik
aut
author
OBJECTIVE: To assess the cost effectiveness of antibiotic prophylaxis for
haematogenous bacterial arthritis in patients with joint disease. METHODS:
In a decision analysis, data from a prospective study on bacterial
arthritis in 4907 patients with joint disease were combined with
literature data to assess risks and benefits of antibiotic prophylaxis.
Effectiveness and cost effectiveness calculations were performed on
antibiotic prophylaxis for various patient groups. Grouping was based on
(a) type of event leading to transient bacteraemia-that is, infections
(dermal, respiratory/urinary tract) and invasive medical procedures-and
(b) the patient's susceptibility to bacterial arthritis which was
increased in the presence of rheumatoid arthritis, large joint prostheses,
comorbidity, and old age. RESULTS: Of the patients with joint disease, 59%
had no characteristics that increased susceptibility to bacterial
arthritis, and 31% had one. For dermal infections, the effectiveness of
antibiotic prophylaxis was maximally 35 quality adjusted life days (QALDs)
and the cost effectiveness maximally $52 000 per quality adjusted life
year (QALY). For other infections, the effectiveness of prophylaxis was
lower and the cost effectiveness higher. Prophylaxis for invasive medical
procedures seemed to be acceptable only in patients with high
susceptibility: 1 QALD at a cost of $1300/QALY; however, the results were
influenced substantially when the level of efficacy of the prophylaxis or
cost of prophylactic antibiotics was changed. CONCLUSION: Prophylaxis
seems to be indicated only for dermal infections, and for infections of
the urinary and respiratory tract in patients with increased
susceptibility to bacterial arthritis. Prophylaxis for invasive medical
procedures, such as dental treatment, may only be indicated for patients
with joint disease who are highly susceptible.
Annals of the Rheumatic Diseases: an international peer-reviewed journal for health professionals and researchers in the rheumatic diseases
10501
00034967
2001-01-01
en
English
*Decision Support Techniques
Adult
Age Factors
Aged
Amoxicillin-Potassium Clavulanate Combination/economics/*therapeutic use
Antibiotic Prophylaxis/*economics
Arthritis
Infectious/*drug therapy/economics/etiology
Arthritis
Rheumatoid/complications
Confidence Intervals
Cost-Benefit Analysis
Drug Therapy
Combination/economics/*therapeutic use
Female
Humans
Logistic Models
Male
Middle aged
Prostheses and Implants
Quality-Adjusted Life Years
ROC Curve
Research Support
Non-U.S. Gov't
Respiratory Tract Infections/drug therapy
Risk Factors
Skin Diseases
Bacterial/drug therapy
Surgical Procedures
Operative
Urinary Tract Infections/drug therapy
Antibiotic prophylaxis for haematogenous bacterial arthritis in patients with joint disease: a cost effectiveness analysis
text
article
107893932
068417853
oai:repub.eur.nl:96119
2023-12-19T12:58:36Z
http://hdl.handle.net/1765/96119
hdl:1765/96119
urn:NBN:nl:ui:15-1765/96119
doi:10.1128/AAC.02821-15
http://hdl.handle.net/1765/96119
Department of Medical Microbiology and Infectious Diseases
sht
supporting host
B.E. Ferro (Beatriz E.)
Ferro
Beatriz E.
aut
author
S. Srivastava (Shashikant)
Srivastava
Shashikant
aut
author
D. Deshpande (Devyani)
Deshpande
Devyani
aut
author
J.G. Pasipanodya (Jotam G.)
Pasipanodya
Jotam G.
aut
author
D. van Soolingen (Dick)
Soolingen
Dick
aut
author
J.W. Mouton (Johan)
Mouton
Johan
aut
author
J. van Ingen (Jakko)
Ingen
Jakko
aut
author
T. Gumbo (Tawanda)
Gumbo
Tawanda
aut
author
Copyright
Antimicrobial Agents and Chemotherapy
11284
00664804
60
6
3779
3785
2016-06-01
en
English
Moxifloxacin's limited efficacy in the hollow-fiber model of Mycobacterium abscessus disease
text
article
oai:repub.eur.nl:96118
2023-12-19T12:58:36Z
oai:repub.eur.nl:96117
2023-12-19T12:58:36Z
oai:repub.eur.nl:96116
2023-12-19T12:58:36Z
oai:repub.eur.nl:96115
2023-12-19T12:58:36Z
oai:repub.eur.nl:96114
2023-12-19T12:58:36Z
oai:repub.eur.nl:96113
2023-12-19T12:58:36Z
oai:repub.eur.nl:96112
2023-12-19T12:58:36Z
oai:repub.eur.nl:96111
2023-12-19T12:58:36Z
oai:repub.eur.nl:96110
2023-12-19T12:58:36Z
http://hdl.handle.net/1765/96110
hdl:1765/96110
urn:NBN:nl:ui:15-1765/96110
doi:10.1136/bmjopen-2016-011926
http://hdl.handle.net/1765/96110
https://repub.eur.nl/pub/96110/REPUB_96110_OA.pdf
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Filesize: 1014409 bytes
born digital
Department of Pediatrics
sht
supporting host
Erasmus School of Health Policy & Management (ESHPM)
sht
supporting host
J.N.T. Sattoe (Jane)
Sattoe
Jane
aut
author
M.A.C. Peeters (Mariëlle A.C.)
Peeters
Mariëlle A.C.
aut
author
S.R. Hilberink (Sander)
Hilberink
Sander
aut
author
E. Ista (Erwin)
Ista
Erwin
aut
author
A.L. van Staa (AnneLoes)
Staa
AnneLoes
aut
author
ABSTRACT
Introduction: To support young people in their
transition to adulthood and transfer to adult care, a
number of interventions have been developed. One
particularly important intervention is the transition
clinic (TC), where paediatric and adult providers
collaborate. TCs are often advocated as best practices
in transition care for young people with chronic
conditions, but little is known about TC models and
effects. The proposed study aims to gain insight into
the added value of a TC compared with usual care
(without a TC).
Methods and analysis: We propose a mixedmethods
study with a retrospective controlled design
consisting of semistructured interviews among
healthcare professionals, observations of consultations
with young people, chart reviews of young people
transferred 2–4 years prior to data collection and
questionnaires among the young people included in
the chart reviews. Qualitative data will be analysed
through thematic analysis and results will provide
insights into structures and daily routines of TCs, and
experienced barriers and facilitators in transitional care.
Quantitatively, within-group differences on clinical
outcomes and healthcare use will be studied over the
four measurement moments. Subsequently,
comparisons will be made between intervention and
control groups on all outcomes at all measurement
moments. Primary outcomes are ‘no-show after
transfer’ ( process outcome) and ‘experiences and
satisfaction with the transfer’ ( patient-reported
outcome). Secondary outcomes consider clinical
outcomes, healthcare usage, self-management
outcomes and perceived quality of care.
Ethics: The Medical Ethical Committee of the
Erasmus Medical Centre approved the study protocol
(MEC-2014-246).
Dissemination: Study results will be disseminated
through peer-reviewed journals and conferences. The
study started in September 2014 and will continue until
December 2016. The same study design will be used in
a national study in 20 diabetes settings (2016–2018).
BMJ Open
20320
20446055
6
8
2016-08-01
en
English
Evaluating outpatient transition clinics: A mixed-methods study protocol
text
article
298682842
oai:repub.eur.nl:9611
2023-12-19T12:58:36Z
http://hdl.handle.net/1765/9611
hdl:1765/9611
urn:NBN:nl:ui:15-1765/9611
http://hdl.handle.net/1765/9611
https://repub.eur.nl/pub/9611/11247783.pdf
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born digital
Erasmus MC: University Medical Center Rotterdam
sht
supporting host
Department of Pharmacology
sht
supporting host
Department of Internal Medicine
sht
supporting host
Department of Biochemistry
sht
supporting host
J.J. Saris (Jasper)
Saris
Jasper
aut
author
F.H.M. Derkx (Frans)
Derkx
Frans
aut
author
R.J.A. de Bruin (René)
Bruin
René
aut
author
D.H. Dekkers (Dick)
Dekkers
Dick
aut
author
J.M.J. Lamers (Jos)
Lamers
Jos
aut
author
P.R. Saxena (Pramod Ranjan)
Saxena
Pramod Ranjan
aut
author
M.A.D.H. Schalekamp (Maarten)
Schalekamp
Maarten
aut
author
A.H.J. Danser (Jan)
Danser
Jan
aut
author
Mannose-6-phosphate (man-6-P)/insulin-like growth factor-II
(man-6-P/IgF-II) receptors are involved in the activation of recombinant
human prorenin by cardiomyocytes. To investigate the kinetics of this
process, the nature of activation, the existence of other prorenin
receptors, and binding of native prorenin, neonatal rat cardiomyocytes
were incubated with recombinant, renal, or amniotic fluid prorenin with or
without man-6-P. Intact and activated prorenin were measured in cell
lysates with prosegment- and renin-specific antibodies, respectively. The
dissociation constant (K(d)) and maximum number of binding sites (B(max))
for prorenin binding to man-6-P/IGF-II receptors were 0.6 +/- 0.1 nM and
3,840 +/- 510 receptors/myocyte, respectively. The capacity for prorenin
internalization was greater than 10 times B(max). Levels of internalized
intact prorenin decreased rapidly (half-life = 5 +/- 3 min) indicating
proteolytic prosegment removal. Prorenin subdivision into man-6-P-free and
man-6-P-containing fractions revealed that only the latter was bound.
Cells also bound and activated renal but not amniotic fluid prorenin. We
concluded that cardiomyocytes display high-affinity binding of renal but
not extrarenal prorenin exclusively via man-6-P/IGF-II receptors. Binding
precedes internalization and proteolytic activation to renin thereby
supporting the concept of cardiac angiotensin formation by renal prorenin.
American Journal of Physiology - Heart and Circulatory Physiology
10879
03636135
2001-01-01
en
English
*Protein Processing
Post-Translational
Amniotic Fluid/enzymology
Animals
Animals
Newborn
Cells
Cultured
Enzyme Activation
Enzyme Precursors/*metabolism
Fibroblasts/metabolism
Humans
Kidney/enzymology
Kinetics
Myocardium/*metabolism
Protease Inhibitors/pharmacology
Protein Binding
Rats
Receptor
IGF Type 2/*metabolism
Recombinant Proteins/metabolism
Renin/*metabolism
Research Support
Non-U.S. Gov't
High-affinity prorenin binding to cardiac man-6-P/IGF-II receptors precedes proteolytic activation to renin
text
article
238677400
072749466
141608862
068034962
093068468
oai:repub.eur.nl:96109
2023-12-19T12:58:36Z
oai:repub.eur.nl:96108
2023-12-19T12:58:36Z
oai:repub.eur.nl:96107
2023-12-19T12:58:36Z
oai:repub.eur.nl:96106
2023-12-19T12:58:36Z
oai:repub.eur.nl:96105
2023-12-19T12:58:36Z
oai:repub.eur.nl:96104
2023-12-19T12:58:36Z
oai:repub.eur.nl:96103
2023-12-19T12:58:36Z
http://hdl.handle.net/1765/96103
hdl:1765/96103
urn:NBN:nl:ui:15-1765/96103
doi:10.1155/2016/6495753
http://hdl.handle.net/1765/96103
https://repub.eur.nl/pub/96103/doi
Filesize: -1 bytes
born digital
Department of Cardiology
sht
supporting host
A. Kardos (Attila)
Kardos
Attila
aut
author
Kis, Z. (Zsuzsanna)
Kis
Z. (Zsuzsanna)
aut
author
Z. Som (Zoltán)
Som
Zoltán
aut
author
Nagy, Z. (Zsofia)
Nagy
Z. (Zsofia)
aut
author
C. Foldesi (Csaba)
Foldesi
Csaba
aut
author
Background. There are little comparative data on catheter ablation of paroxysmal atrial fibrillation (AF) using the contact force radiofrequency (CF-RF) catheter versus the second-generation cryoballoon (CB2). Methods and results. This is a single center, retrospective, nonrandomized study of 98 patients with symptomatic, drug-refractory paroxysmal AF who underwent their first PVI ablation using either the CB2 (n=40) or CF-RF (n=58). The mean age was 60 years with 63% men, a mean LA size of 42 mm. The procedure duration (74±17 versus 120±49 minutes p<0.05) was shorter for CB2 group; the fluoroscopy time (14±17 versus 16±5 minutes, p=0.45) was similar. Complete PVI was achieved in 96% of patients with RF-CF and 98% with CB2. Phrenic nerve palsies (2 transient and 1 persistent) occurred exclusively in the CB2 group and 1 severe, nonlethal complication (pericardial tamponade) occurred in the CF-RF group. At 24-month follow-up, the success rate, defined as freedom from AF/atrial tachycardia (AT) after a single procedure without antiarrhythmic drug, was comparable in CF-RF group and CB2 group (65.5% versus 67%, resp., log rank p=0.54). Conclusion. Both the CB2 and the RF-CF ablation appeared safe; the success rate at 2 years was comparable between both technologies.
BioMed Research International
20222
23146133
2016
2016-01-01
en
English
Two-Year Follow-Up after Contact Force Sensing Radiofrequency Catheter and Second-Generation Cryoballoon Ablation for Paroxysmal Atrial Fibrillation: A Comparative Single Centre Study
text
article
oai:repub.eur.nl:96102
2023-12-19T12:58:36Z
oai:repub.eur.nl:96101
2023-12-19T12:58:36Z
oai:repub.eur.nl:96100
2023-12-19T12:58:36Z
oai:repub.eur.nl:9610
2023-12-19T12:58:36Z
http://hdl.handle.net/1765/9610
hdl:1765/9610
urn:NBN:nl:ui:15-1765/9610
http://hdl.handle.net/1765/9610
https://repub.eur.nl/pub/9610/11246885.pdf
application/pdf
Filesize: 303246 bytes
born digital
Erasmus MC: University Medical Center Rotterdam
sht
supporting host
Department of Internal Medicine
sht
supporting host
N. Vaessen (Norbert)
Vaessen
Norbert
aut
author
J.C.M. Witteman (Jacqueline)
Witteman
Jacqueline
aut
author
L. Testers
Testers
L.
aut
author
S.W.J. Lamberts (Steven)
Lamberts
Steven
aut
author
B.A. Oostra (Ben)
Oostra
Ben
aut
author
H.A.P. Pols (Huib)
Pols
Huib
aut
author
C.M. van Duijn (Cornelia)
Duijn
Cornelia
aut
author
J.A.M.J.L. Janssen (Joop)
Janssen
Joop
aut
author
P. Heutink (Peter)
Heutink
Peter
aut
author
A. Hofman (Albert)
Hofman
Albert
aut
author
Evidence is accumulating that low levels of IGF-I play a role in the pathogenesis of type 2 diabetes and cardiovascular diseases. We examined the role of a genetic polymorphism in the promoter region of the IGF-I gene in relation to circulating IGF-I levels and growth measured as body height, and we studied the relationship of this polymorphism with type 2 diabetes and myocardial infarction. The relation between the IGF-I polymorphism and body height was assessed in a population-based sample of 900 subjects from the Rotterdam Study. Within each genotype stratum, 50 subjects were randomly selected for a study of the relation of this polymorphism with serum IGF-I levels. To assess the risk for type 2 diabetes, we studied 220 patients and 596 normoglycemic control subjects. For myocardial infarction, 477 patients with evidence of myocardial infarction on electrocardiogram and 808 control subjects were studied. A 192-bp allele was present in 88% of the population, suggesting that this is the wild-type allele from which all other alleles originated. Body height was, on average, 2.7 cm lower (95% CI for difference -4.6 to -0.8 cm, P = 0.004), and serum IGF-I concentrations were 18% lower (95% CI for difference -6.0 to -1.3 mmol/l, P = 0.003) in subjects who did not carry the 192-bp allele. In noncarriers of the 192-bp allele, an increased relative risk for type 2 diabetes (1.7 [95% CI 1.1-2.7]) and for myocardial infarction (1.7 [95% CI 1.1-2.5]) was found. In patients with type 2 diabetes, the relative risk for myocardial infarction in subjects without the 192-bp allele was 3.4 (95% CI 1.1-11.3). Our study suggests that a genetically determined exposure to relatively low IGF-I levels is associated with an increased risk for type 2 diabetes and myocardial infarction.
Diabetes
14103
00121797
2001-01-01
en
English
*Genetic Predisposition to Disease
*Polymorphism
Genetic/physiology
Aged
Alleles
Body Height
Diabetes Mellitus
Type 2/blood/*genetics
Female
Humans
Insulin-Like Growth Factor I/analysis/*genetics/physiology
Male
Middle aged
Myocardial Infarction/blood/*genetics
Promoter Regions (Genetics)/genetics
Reference Values
Research Support
Non-U.S. Gov't
A polymorphism in the gene for IGF-I: functional properties and risk for type 2 diabetes and myocardial infarction
text
article
07101876X
071235035
068336667
073522368
085431621
173093477
069249733
oai:repub.eur.nl:961
2023-12-19T12:58:36Z
http://hdl.handle.net/1765/961
hdl:1765/961
urn:NBN:nl:ui:15-1765/961
doi:10.1016/S0749-596X(03)00020-2
http://hdl.handle.net/1765/961
https://repub.eur.nl/pub/961/PSY003.pdf
application/pdf
Filesize: 80761 bytes
born digital
Department of Psychology
sht
supporting host
Erasmus School of Social and Behavioural Sciences
sht
supporting host
R. Zeelenberg (René)
Zeelenberg
René
aut
author
D. Pecher (Diane)
Pecher
Diane
aut
author
Previous studies have failed to find evidence for long-term
cross-language repetition priming (e.g., presentation of the English
word frog does not facilitate responding to its Dutch translation
equivalent kikker on a later presentation). The present study tested the
hypothesis that failure to find cross-language repetition priming in
previous studies was due to the use of tasks that rely primarily on
lexical or orthographic processing of the stimuli instead of conceptual
processing. Consistent with this hypothesis we obtained reliable
cross-language repetition priming when conceptual implicit memory tasks
were used. The present results support theories of bilingual memory that
assume shared conceptual representations for translation equivalents.
Journal of Memory and Language
13101
0749596X
49
1
80
94
2003-07-01
en
English
bilingualism
concepts
memory
priming
Evidence for long-term cross-language repetition priming in conceptual implicit memory tasks
text
article
172238692
29867338X
oai:repub.eur.nl:96099
2023-12-19T12:58:36Z
oai:repub.eur.nl:96098
2023-12-19T12:58:36Z
http://hdl.handle.net/1765/96098
hdl:1765/96098
urn:NBN:nl:ui:15-1765/96098
doi:10.1007/s12529-016-9546-y
http://hdl.handle.net/1765/96098
https://repub.eur.nl/pub/96098/REPUB_96098-OA.pdf
application/pdf
Filesize: 683944 bytes
born digital
Erasmus School of Health Policy & Management (ESHPM)
sht
supporting host
J.F. Ybema (Jan Fekke)
Ybema
Jan Fekke
aut
author
L. van der Meer (Laudry)
van der Meer
Laudry
aut
author
F.R.M. Leijten (Fenna)
Leijten
Fenna
aut
author
Â
International Journal of Behavioral Medicine
13469
10705503
23
5
645
654
2016-10-01
en
English
Longitudinal study
Older employees
Organizational justice
Productivity loss
Sickness absence
Longitudinal Relationships Between Organizational Justice, Productivity Loss, and Sickness Absence Among Older Employees
text
article
oai:repub.eur.nl:96097
2023-12-19T12:58:36Z
oai:repub.eur.nl:96096
2023-12-19T12:58:36Z
oai:repub.eur.nl:96095
2023-12-19T12:58:36Z
oai:repub.eur.nl:96094
2023-12-19T12:58:36Z
http://hdl.handle.net/1765/96094
hdl:1765/96094
urn:NBN:nl:ui:15-1765/96094
doi:10.7150/thno.15311
http://hdl.handle.net/1765/96094
https://repub.eur.nl/pub/96094/v06p1821.pdf
application/pdf
Filesize: 2546866 bytes
born digital
Erasmus MC: University Medical Center Rotterdam
sht
supporting host
Department of Radiology
sht
supporting host
Department of Radiation Oncology
sht
supporting host
Department of Surgery
sht
supporting host
Department of Pathology
sht
supporting host
J. Nonnekens (Julie)
Nonnekens
Julie
aut
author
M. van Kranenburg (Melissa)
van Kranenburg
Melissa
aut
author
C.E.M.T. Beerens (Cecile)
Beerens
Cecile
aut
author
M. Suker (Mustafa)
Suker
Mustafa
aut
author
M. Doukas (Michael)
Doukas
Michael
aut
author
C.H.J. van Eijck (Casper)
Eijck
Casper
aut
author
M. de Jong (Marcel)
Jong
Marcel
aut
author
D.C. van Gent (Dik)
Gent
Dik
aut
author
Metastases expressing tumor-specific receptors can be targeted and treated by binding of radiolabeled peptides (peptide receptor radionuclide therapy or PRRT). For example, patients with metastasized somatostatin receptor-positive neuroendocrine tumors (NETs) can be treated with radiolabeled somatostatin analogues, resulting in strongly increased progression-free survival and quality of life. There is nevertheless still room for improvement, as very few patients can be cured at this stage of disease. We aimed to specifically sensitize replicating tumor cells without further damage to healthy tissues. Thereto we investigated the DNA damaging effects of PRRT with the purpose to enhance these effects through modulation of the DNA damage response. Although PRRT induces DNA double strand breaks (DSBs), a larger fraction of the induced lesions are single strand breaks (expected to be similar to those induced by external beam radiotherapy) that require poly-[ADP-ribose]-polymerase 1 (PARP-1) activity for repair. If these breaks cannot be repaired, they will cause replication fork arrest and DSB formation during replication. Therefore, we used the PARP-1 inhibitor Olaparib to increase the number of cytotoxic DSBs. Here we show that this new combination strategy synergistically sensitized somatostatin receptor expressing cells to PRRT. We observed increased cell death and reduced cellular proliferation compared to the PRRT alone. The enhanced cell death was caused by increased numbers of DSBs that are repaired with remarkably slow kinetics, leading to genome instability. Furthermore, we validated the increased DSB induction after PARP inhibitor addition in the clinically relevant model of living human NET slices. We expect that this combined regimen can thus augment current PRRT outcomes.
Theranostics
22408
18387640
6
11
1821
1832
2016-07-18
en
English
177Lu-DOTA-[Tyr3]octreotate
Combination treatment
DNA damage response
Neuroendocrine tumors
PARP inhibitor
Peptide receptor radionuclide therapy
Somatostatin receptor
Potentiation of peptide receptor radionuclide therapy by the PARP inhibitor olaparib
text
article
29868442X
122023765
108601242
oai:repub.eur.nl:96093
2023-12-19T12:58:36Z
oai:repub.eur.nl:96092
2023-12-19T12:58:36Z
oai:repub.eur.nl:96091
2023-12-19T12:58:36Z
http://hdl.handle.net/1765/96091
hdl:1765/96091
urn:NBN:nl:ui:15-1765/96091
doi:10.1016/j.neurobiolaging.2016.04.004
http://hdl.handle.net/1765/96091
https://repub.eur.nl/pub/96091/REPUB_96091-OA.pdf
application/pdf
Filesize: 712095 bytes
born digital
Department of Neurology
sht
supporting host
Sassi, C. (Celeste)
Sassi
C. (Celeste)
aut
author
M.A. Nalls (Michael)
Nalls
Michael
aut
author
Ridge, P.G. (Perry G.)
Ridge
P.G. (Perry G.)
aut
author
J.R. Gibbs (J Raphael)
Gibbs
J Raphael
aut
author
Ding, J. (Jinhui)
Ding
J. (Jinhui)
aut
author
M.K. Lupton (Michelle)
Lupton
Michelle
aut
author
C. Troakes (Claire)
Troakes
Claire
aut
author
Lunnon, K. (Katie)
Lunnon
K. (Katie)
aut
author
S. Al-Sarraj (Safa)
Al-Sarraj
Safa
aut
author
K. Brown (Kristelle)
Brown
Kristelle
aut
author
C. Medway (Christopher)
Medway
Christopher
aut
author
Clement, N. (Naomi)
Clement
N. (Naomi)
aut
author
Lord, J. (Jenny)
Lord
J. (Jenny)
aut
author
J.C. Turton (James)
Turton
James
aut
author
J. Bras (Jose)
Bras
Jose
aut
author
Almeida, M.R. (Maria R.)
Almeida
M.R. (Maria R.)
aut
author
P. Passmore (Peter)
Passmore
Peter
aut
author
D. Craig (David)
Craig
David
aut
author
J.A. Johnston (Janet)
Johnston
Janet
aut
author
McGuinness, B. (Bernadette)
McGuinness
B. (Bernadette)
aut
author
S. Todd (Stephen)
Todd
Stephen
aut
author
R. Heun (Reinhard)
Heun
Reinhard
aut
author
H. Kölsch (Heike)
Kölsch
Heike
aut
author
P.G. Kehoe (Patrick)
Kehoe
Patrick
aut
author
E.R.L.C. Vardy (Emma)
Vardy
Emma
aut
author
N.M. Hooper (Nigel Mark)
Hooper
Nigel Mark
aut
author
D. Mann (David)
Mann
David
aut
author
S. Pickering-Brown (Stuart)
Pickering-Brown
Stuart
aut
author
Brown, K. (Kristelle)
Brown
K. (Kristelle)
aut
author
Lowe, J. (James)
Lowe
J. (James)
aut
author
K. Morgan (Kevin)
Morgan
Kevin
aut
author
A.D. Smith (David)
Smith
David
aut
author
G.K. Wilcock (Gordon)
Wilcock
Gordon
aut
author
D.R. Warden (Donald)
Warden
Donald
aut
author
C. Holmes (Clive)
Holmes
Clive
aut
author
H. Holstege (Henne)
Holstege
Henne
aut
author
E. Louwersheimer (Eva)
Louwersheimer
Eva
aut
author
W.M. van der Flier (Wiesje)
Flier
Wiesje
aut
author
P. Scheltens (Philip)
Scheltens
Philip
aut
author
J.C. van Swieten (John)
Swieten
John
aut
author
Santana, I. (Isabel)
Santana
I. (Isabel)
aut
author
C.R. Oliveira (Catarina Resende)
Oliveira
Catarina Resende
aut
author
Morgan, K. (Kevin)
Morgan
K. (Kevin)
aut
author
J. Powell (John)
Powell
John
aut
author
J.S.K. Kauwe (John)
Kauwe
John
aut
author
C. Cruchaga (Carlos)
Cruchaga
Carlos
aut
author
A.M. Goate (Alison M.)
Goate
Alison M.
aut
author
A. Singleton (Andrew)
Singleton
Andrew
aut
author
R. Guerreiro (Rita)
Guerreiro
Rita
aut
author
Hardy, J. (John)
Hardy
J. (John)
aut
author
Genome-wide association studies (GWASs) have been effective approaches to dissect common genetic variability underlying complex diseases in a systematic and unbiased way. Recently, GWASs have led to the discovery of over 20 susceptibility loci for Alzheimer's disease (AD). Despite the evidence showing the contribution of these loci to AD pathogenesis, their genetic architecture has not been extensively investigated, leaving the possibility that low frequency and rare coding variants may also occur and contribute to the risk of disease. We have used exome and genome sequencing data to analyze the single independent and joint effect of rare and low-frequency protein coding variants in 9 AD GWAS loci with the strongest effect sizes after APOE (BIN1, CLU, CR1, PICALM, MS4A6A, ABCA7, EPHA1, CD33, and CD2AP) in a cohort of 332 sporadic AD cases and 676 elderly controls of British and North-American ancestry. We identified coding variability in ABCA7 as contributing to AD risk. This locus harbors a low-frequency coding variant (p.G215S, rs72973581, minor allele frequency = 4.3%) conferring a modest but statistically significant protection against AD (p-value = 0.024, odds ratio = 0.57, 95% confidence interval = 0.41–0.80). Notably, our results are not driven by an enrichment of loss of function variants in ABCA7, recently reported as main pathogenic factor underlying AD risk at this locus. In summary, our study confirms the role of ABCA7 in AD and provides new insights that should address functional studies.
Neurobiology of Aging: age-related phenomena, neurodegeneration and neuropathology
12770
01974580
46
235.e1
235.e9
2016-10-01
en
English
ABCA7
Alzheimer's disease (AD)
Genome-wide association studies (GWASs)
Protective variant
Whole exome sequencing (WES)
Whole genome sequencing (WGS)
ABCA7 p.G215S as potential protective factor for Alzheimer's disease
text
article
096418435
oai:repub.eur.nl:96090
2023-12-19T12:58:36Z
oai:repub.eur.nl:9609
2023-12-19T12:58:36Z
http://hdl.handle.net/1765/9609
hdl:1765/9609
urn:NBN:nl:ui:15-1765/9609
http://hdl.handle.net/1765/9609
https://repub.eur.nl/pub/9609/11245741.pdf
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Filesize: 244819 bytes
born digital
Erasmus MC: University Medical Center Rotterdam
sht
supporting host
E.C. Alexopoulos (Evangelos)
Alexopoulos
Evangelos
aut
author
A. Burdorf (Alex)
Burdorf
Alex
aut
author
OBJECTIVES: To analyze factors that determine the occurrence of sickness
absence due to respiratory disorders and the time it takes to return to
work. METHODS: A longitudinal study with 2 year follow up was conducted
among 326 male blue collar and white collar workers. The survey started
with an interview on respiratory complaints and spirometry. Sixty six
(21%) workers were lost to follow up. Complete data on sickness absence
among 251 workers during the follow up were collected from absence records
and self reports. Regression analysis based on a proportional hazards
model was applied to identify risk factors for the occurrence and duration
of sickness absence due to respiratory disorders. RESULTS: During the
follow up 35% workers attributed at least one period of sickness absence
to respiratory complaints, which accounted for 14.2% of all days lost. A
history of chronic obstructive pulmonary disease (COPD) did not predict
sickness absence for COPD; the same was true for chronic non-specific lung
disease (CNSLD). Complaints about asthma contributed significantly to
absence due to asthma (relative risk (RR) 3.96; 95% confidence interval
(95% CI) 1.99 to 7.90). Job title was a significant predictor of sickness
absence due to respiratory complaints. Decrease in forced vital capacity
(FVC, <80% of the reference value) was also a significant predictor of
absence due to asthma (RR 4.03; 95% CI 1.41 to 11.54) and of respiratory
absence (RR 2.49; 95% CI 1.07 to 5.79). Absence with respiratory
complaints was not associated with age, height, body mass index, or
smoking. Duration of employment was a weak almost significant predictor
against respiratory absenteeism (RR 0.94; 95% CI 0.91 to 0.97). Return to
work after respiratory absence was worse for blue collar workers than
office personnel (RR 5.74; 95% CI 1.90 to 17.4 for welders, and RR 6.43;
95% CI 2.08 to 19.85 for metal workers). CONCLUSIONS: Asthmatic complaints
in the 12 months before the study were associated with sickness absence
for these complaints during the follow up. An abnormal level of FVC also
influenced respiratory absenteeism. Blue collar workers had more often and
more prolonged absences due to respiratory disorders than white collar
workers. Workers with absence due to respiratory complaints were at higher
risk of subsequent sickness absence in the next year.
Occupational and Environmental Medicine: an international peer-reviewed journal in all aspects of occupational & environmental medicine
13311
13510711
2001-01-01
en
English
*Absenteeism
*Commerce
*Metallurgy
*Welding
Adult
Asthma/etiology/physiopathology
Comparative Study
Humans
Longitudinal Studies
Lung Diseases, Obstructive/etiology/physiopathology
Lung Diseases/*etiology/physiopathology
Male
Prognosis
Proportional Hazards Models
Recurrence
Research Support, Non-U.S. Gov't
Risk Factors
Time Factors
Vital Capacity
Prognostic factors for respiratory sickness absence and return to work among blue collar workers and office personnel
text
article
073354015
oai:repub.eur.nl:96089
2023-12-19T12:58:36Z
oai:repub.eur.nl:96088
2023-12-19T12:58:36Z
oai:repub.eur.nl:96087
2023-12-19T12:58:36Z
http://hdl.handle.net/1765/96087
hdl:1765/96087
urn:NBN:nl:ui:15-1765/96087
doi:10.1155/2016/7105678
http://hdl.handle.net/1765/96087
https://repub.eur.nl/pub/96087/REPUB_96087-OA.pdf
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Filesize: 1305376 bytes
born digital
Department of Urology
sht
supporting host
Department of Public Health
sht
supporting host
P.J. van Leeuwen (Pim)
Leeuwen
Pim
aut
author
Siriwardana, A. (Amila)
Siriwardana
A. (Amila)
aut
author
M.J. Roobol-Bouts (Monique)
Roobol-Bouts
Monique
aut
author
Ting, F. (Francis)
Ting
F. (Francis)
aut
author
D. Nieboer (Daan)
Nieboer
Daan
aut
author
Thompson, J. (James)
Thompson
J. (James)
aut
author
W.J. Delprado (Warick)
Delprado
Warick
aut
author
Haynes, A.-M. (Anne-Marie)
Haynes
A.-M. (Anne-Marie)
aut
author
Brenner, P. (Phillip)
Brenner
P. (Phillip)
aut
author
Stricker, P. (Phillip)
Stricker
P. (Phillip)
aut
author
Introduction. To assess the performance of five previously described clinicopathological definitions of low-risk prostate cancer (PC). Materials and Methods. Men who underwent radical prostatectomy (RP) for clinical stage ≤T2, PSA <10 ng/mL, Gleason score <8 PC, diagnosed by transperineal template-guided saturation biopsy were included. The performance of five previously described criteria (i.e., criteria 1-5, criterion 1 stringent (Gleason score 6 + ≤5 mm total max core length PC + ≤3 mm max per core length PC) up to criterion 5 less stringent (Gleason score 6-7 with ≤5% Gleason grade 4) was analysed to assess ability of each to predict insignificant disease in RP specimens (defined as Gleason score ≤6 and total tumour volume <2.5 mL, or Gleason score 7 with ≤5% grade 4 and total tumour volume <0.7 mL). Results. 994 men who underwent RP were included. Criterion 4 (Gleason score 6) performed best with area under the curve of receiver operating characteristics 0.792. At decision curve analysis, criterion 4 was deemed clinically the best performing transperineal saturation biopsy-based definition for low-risk PC. Conclusions. Gleason score 6 disease demonstrated a superior trade-off between sensitivity and specificity for clarifying low-risk PC that can guide treatment and be used as reference test in diagnostic studies.
2016-01-01
en
English
Predicting low-risk prostate cancer from transperineal saturation biopsies
text
article
290801834
oai:repub.eur.nl:96086
2023-12-19T12:58:36Z
oai:repub.eur.nl:96085
2023-12-19T12:58:36Z
oai:repub.eur.nl:96083
2023-12-19T12:58:36Z
http://hdl.handle.net/1765/96083
hdl:1765/96083
urn:NBN:nl:ui:15-1765/96083
doi:10.18632/oncotarget.9727
http://hdl.handle.net/1765/96083
https://repub.eur.nl/pub/96083/9727-148116-4-PB.pdf
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Filesize: 6826037 bytes
born digital
Erasmus MC: University Medical Center Rotterdam
sht
supporting host
M.P.H.M. Jansen (Maurice)
Jansen
Maurice
aut
author
J.W.M. Martens (John)
Martens
John
aut
author
J. Helmijr (Jean)
Helmijr
Jean
aut
author
C.M. Beaufort (Corine M.)
Beaufort
Corine M.
aut
author
R. van Marion (Ronald)
Marion
Ronald
aut
author
N.M.G. Krol (Niels M. G.)
Krol
Niels M. G.
aut
author
K. Monkhorst (Kim)
Monkhorst
Kim
aut
author
A.M.A.C. Trapman-Jansen (Anita M.A.C.)
Trapman-Jansen
Anita M.A.C.
aut
author
M.E. Meijer van Gelder (Marion)
Meijer van Gelder
Marion
aut
author
M.J.A. Weerts (Marjolein)
Weerts
Marjolein
aut
author
D.E. Ramirez Ardila (Diana)
Ramirez Ardila
Diana
aut
author
H.J. Dubbink (Erik Jan)
Dubbink
Erik Jan
aut
author
J.A. Foekens (John)
Foekens
John
aut
author
S. Sleijfer (Stefan)
Sleijfer
Stefan
aut
author
P.M.J.J. Berns (Els)
Berns
Els
aut
author
The aim was to identify mutations in serum cell-free DNA (cfDNA) associated with disease progression on tamoxifen treatment in metastatic breast cancer (MBC). Sera available at start of therapy, during therapy and at disease progression were selected from 10 estrogen receptor (ER)-positive breast cancer patients. DNA from primary tumor and normal tissue and cfDNA from minute amounts of sera were analyzed by targeted next generation sequencing (NGS) of 45 genes (1,242 exons). At disease progression, stop-gain single nucleotide variants (SNVs) for CREBBP (1 patient) and SMAD4 (1 patient) and non-synonymous SNVs for AKAP9 (1 patient), PIK3CA (2 patients) and TP53 (2 patients) were found. Mutations in CREBBP and SMAD4 have only been occasionally reported in breast cancer. All mutations, except for AKAP9, were also present in the primary tumor but not detected in all blood specimens preceding progression. More sensitive detection by deeper re-sequencing and digital PCR confirmed the occurrence of circulating tumor DNA (ctDNA) and these biomarkers in blood specimens.
Oncotarget
22019
19492553
7
28
43412
43418
2016-01-01
en
English
Breast cancer
Cell-free DNA
Disease progression
Tamoxifen therapy
Targeted next generation sequencing
Cell-free DNA mutations as biomarkers in breast cancer patients receiving tamoxifen
text
article
175565120
127708227
29869803X
188930981
068835442
163934053
072054212
oai:repub.eur.nl:96082
2023-12-19T12:58:36Z
oai:repub.eur.nl:96081
2023-12-19T12:58:36Z
oai:repub.eur.nl:96080
2023-12-19T12:58:36Z
oai:repub.eur.nl:9608
2023-12-19T12:58:36Z
http://hdl.handle.net/1765/9608
hdl:1765/9608
urn:NBN:nl:ui:15-1765/9608
http://hdl.handle.net/1765/9608
https://repub.eur.nl/pub/9608/11245445.pdf
application/pdf
Filesize: 58238 bytes
born digital
Erasmus MC: University Medical Center Rotterdam
sht
supporting host
J.A. Foekens (John)
Foekens
John
aut
author
S. Romain
Romain
S.
aut
author
M.P. Look (Maxime)
Look
Maxime
aut
author
P.M. Martin
Martin
P.M.
aut
author
J.G.M. Klijn (Jan)
Klijn
Jan
aut
author
Thymidylate synthase (TS) is a crucial target for 5-fluorouracil (5-FU) in
the de novo pathway of pyrimidine synthesis, which is necessary for DNA
synthesis. Thymidine kinase (TK) plays a key role in the complementary or
alternative salvage pathway of pyrimidine synthesis in acute or
pathological tissue stress. In the present study, the activity levels of
TS and TK were determined in 257 primary breast tumors of patients who
received tamoxifen as first-line systemic therapy after diagnosis of
advanced disease. In 155 (60%) responding patients, the median response
duration was 23 months for tumors with low TK activity, 15 months for
tumors with intermediate TK activity, and 13 months for tumors with high
TK activity (P = 0.003). In Cox multivariate analysis corrected for
classical predictive factors including estrogen receptor and progesterone
receptor, patients with intermediate and high levels of TK activity in
their tumors showed a rapid disease progression (P = 0.0002) and an early
death (P = 0.002) after start of tamoxifen treatment. Tumor TS activity
levels were not significantly associated with the efficacy of tamoxifen
treatment. In 121 patients who became resistant to tamoxifen or additional
endocrine treatments and who received 5-FU-containing polychemotherapy,
tumor TK activity was not significantly related to the efficacy of
chemotherapy. Of the 13 patients with low tumor TS activity, only 1 (8%)
responded favorably, whereas 46% (43 of 93) of those with intermediate and
73% (11 of 15) of those with high TS activity responded (P = 0.001). In
Cox multivariate regression analysis in which TS was the only significant
variable, intermediate and high TS activities were associated with a slow
disease progression (P = 0.005) and prolonged survival (P = 0.016) on
chemotherapy. In conclusion, for patients with recurrent breast cancer,
high tumor TK activity is a significant marker of poor clinical outcome on
tamoxifen therapy. Elevated tumor TS activity predicts a favorable outcome
for 5-FU-containing polychemotherapy when applied after tumor progression
on endocrine therapy.
Cancer Research
13068
00085472
2001-01-01
en
English
Adult
Aged
Aged, 80 and over
Antineoplastic Agents, Hormonal/*therapeutic use
Antineoplastic Combined Chemotherapy Protocols/administration & dosage/*therapeutic use
Breast Neoplasms/*drug therapy/*enzymology
Cyclophosphamide/administration & dosage
Disease-Free Survival
Doxorubicin/administration & dosage
Drug Resistance, Neoplasm
Epirubicin/administration & dosage
Female
Fluorouracil/administration & dosage
Humans
Methotrexate/administration & dosage
Middle aged
Neoplasm Recurrence, Local/drug therapy/enzymology
Research Support, Non-U.S. Gov't
Tamoxifen/*therapeutic use
Thymidine Kinase/*metabolism
Thymidylate Synthase/*metabolism
Thymidine kinase and thymidylate synthase in advanced breast cancer: response to tamoxifen and chemotherapy
text
article
068835442
298697971
072749490
oai:repub.eur.nl:96079
2023-12-19T12:58:36Z
oai:repub.eur.nl:96078
2023-12-19T12:58:36Z
oai:repub.eur.nl:96077
2023-12-19T12:58:36Z
http://hdl.handle.net/1765/96077
hdl:1765/96077
urn:NBN:nl:ui:15-1765/96077
doi:10.7819/rbgn.v18i59.2769
http://hdl.handle.net/1765/96077
https://repub.eur.nl/pub/96077/REPUB_96077.pdf
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Filesize: 1190451 bytes
born digital
Rotterdam School of Management (RSM), Erasmus University
sht
supporting host
Ferreira, L.C.M. (Luciana Carvalho de Mesquita)
Ferreira
L.C.M. (Luciana Carvalho de Mesquita)
aut
author
Rais, L.A. (Luciano Aversani)
Rais
L.A. (Luciano Aversani)
aut
author
Purpose – This study aims to analyze the relationship between
greater participation of people with disabilities in Brazilian firms and
productivity as a performance indicator.
Design/methodology/approach – To test the relationship between the
proportion of PwD and the productivity of Brazilian firms, we used
regression analysis with panel data and a dataset of public information
from 46 firms for years 2010 and 2011.
Findings – There was no statistical evidence stating that a greater
proportion of people with disabilities in the workforce has a negative
(or positive) relationship with the productivity of Brazilian firms.
Conversely, a positive relationship between a greater proportion of
people with disabilities and productivity was found amongst firms that
present greater social commitment.
Originality/value – These results indicate the contingent character
associated with diversity management, and that the adoption of social
practices by Brazilian firms can be an important mechanism for the
management of diversity and inclusion.
2016-01-01
en
English
People with disabilities
productivity
social commitment
What is the relationship between diversity and performance? A study about the relationship between the proportion of people with disabilities in the productivity of Brazilian firms
text
article
oai:repub.eur.nl:96076
2023-12-19T12:58:36Z
http://hdl.handle.net/1765/96076
hdl:1765/96076
urn:NBN:nl:ui:15-1765/96076
doi:10.1038/nn.4321
http://hdl.handle.net/1765/96076
Biophysical Genomics, Department Cell Biology & Genetics
sht
supporting host
Quintes, S. (Susanne)
Quintes
S. (Susanne)
aut
author
B.G. Brinkmann (Bastian)
Brinkmann
Bastian
aut
author
Ebert, M. (Madlen)
Ebert
M. (Madlen)
aut
author
Fröb, F. (Franziska)
Fröb
F. (Franziska)
aut
author
Kungl, T. (Theresa)
Kungl
T. (Theresa)
aut
author
Arlt, F.A. (Friederike A)
Arlt
F.A. (Friederike A)
aut
author
Tarabykin, V. (Victor)
Tarabykin
V. (Victor)
aut
author
D. Huylebroeck (Danny)
Huylebroeck
Danny
aut
author
D.N. Meijer (Dies)
Meijer
Dies
aut
author
U. Suter (Ueli)
Suter
Ueli
aut
author
M. Wegner (Michael)
Wegner
Michael
aut
author
M.W. Sereda (Michael)
Sereda
Michael
aut
author
K.-A. Nave
Nave
K.-A.
aut
author
Schwann cell development and peripheral nerve myelination require the serial expression of transcriptional activators, such as Sox10, Oct6 (also called Scip or Pou3f1) and Krox20 (also called Egr2). Here we show that transcriptional repression, mediated by the zinc-finger protein Zeb2 (also known as Sip1), is essential for differentiation and myelination. Mice lacking Zeb2 in Schwann cells develop a severe peripheral neuropathy, caused by failure of axonal sorting and virtual absence of myelin membranes. Zeb2-deficient Schwann cells continuously express repressors of lineage progression. Moreover, genes for negative regulators of maturation such as Sox2 and Ednrb emerge as Zeb2 target genes, supporting its function as an inhibitor of inhibitors in myelination control. When Zeb2 is deleted in adult mice, Schwann cells readily dedifferentiate following peripheral nerve injury and become repair cells. However, nerve regeneration and remyelination are both perturbed, demonstrating that Zeb2, although undetectable in adult Schwann cells, has a latent function throughout life.
Nature Neuroscience
11333
10976256
19
8
1050
1059
2016-08-01
en
English
Zeb2 is essential for Schwann cell differentiation, myelination and nerve repair
text
article
096354526
oai:repub.eur.nl:96075
2023-12-19T12:58:36Z
oai:repub.eur.nl:96074
2023-12-19T12:58:36Z
oai:repub.eur.nl:96073
2023-12-19T12:58:36Z
http://hdl.handle.net/1765/96073
hdl:1765/96073
urn:NBN:nl:ui:15-1765/96073
doi:10.1128/AAC.00990-16
http://hdl.handle.net/1765/96073
Department of Medical Microbiology and Infectious Diseases
sht
supporting host
B.E. Ferro (Beatriz E.)
Ferro
Beatriz E.
aut
author
S. Srivastava (Shashikant)
Srivastava
Shashikant
aut
author
D. Deshpande (Devyani)
Deshpande
Devyani
aut
author
J.G. Pasipanodya (Jotam G.)
Pasipanodya
Jotam G.
aut
author
D. van Soolingen (Dick)
Soolingen
Dick
aut
author
J.W. Mouton (Johan)
Mouton
Johan
aut
author
J. van Ingen (Jakko)
Ingen
Jakko
aut
author
T. Gumbo (Tawanda)
Gumbo
Tawanda
aut
author
Copyright
Antimicrobial Agents and Chemotherapy
11284
00664804
60
10
6374
6376
2016-10-01
en
English
Failure of the amikacin, cefoxitin, and clarithromycin combination regimen for treating pulmonary Mycobacterium abscessus infection
text
article
oai:repub.eur.nl:96072
2023-12-19T12:58:36Z
http://hdl.handle.net/1765/96072
hdl:1765/96072
urn:NBN:nl:ui:15-1765/96072
doi:10.1007/s00384-016-2616-4
http://hdl.handle.net/1765/96072
https://repub.eur.nl/pub/96072/art-3A10.1007-2Fs00384-016-2616-4.pdf
application/pdf
Filesize: 1143954 bytes
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Department of Surgery
sht
supporting host
Department of Neuroscience
sht
supporting host
Z. Wu (Zhouqiao)
Wu
Zhouqiao
aut
author
van de Haar, R.C.J. (Remondus C. J.)
van de Haar
R.C.J. (Remondus C. J.)
aut
author
C.L. Sparreboom (Cloë)
Sparreboom
Cloë
aut
author
G.S.A. ter Hoeve-Boersema (Simone)
Hoeve-Boersema
Simone
aut
author
Li, Z. (Ziyu)
Li
Z. (Ziyu)
aut
author
J. Ji (Jiafu)
Ji
Jiafu
aut
author
J. Jeekel (Hans)
Jeekel
Hans
aut
author
J.F. Lange (Johan)
Lange
Johan
aut
author
International Journal of Colorectal Disease: clinical and molecular gastroenterology and surgery
11608
01791958
31
8
1409
1417
2016-08-01
en
English
Air leak test
Anastomotic leakage
Colorectal surgery
Prevention
Is the intraoperative air leak test effective in the prevention of colorectal anastomotic leakage? A systematic review and meta-analysis
text
review
069209391
298685469
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