%PDF-1.6
%
1 0 obj
<>
endobj
2 0 obj
<>stream
Stephanie Medlock, Juliette L. Parlevliet, Danielle Sent, Saeid Eslami, Marjan Askari, Derk L. Arts, Joost B. Hoekstra, Sophia E. de Rooij, Ameen Abu-Hanna
An email-based intervention to improve the number and timeliness of letters sent from the hospital outpatient clinic to the general practitioner: A pair-randomized controlled trial
www.plosone.org
www.plosone.org
endstream
endobj
3 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 11 0 R/Annots 12 0 R/Contents 13 0 R/TrimBox[0 0 612 792]>>
endobj
12 0 obj
[14 0 R 15 0 R 16 0 R 17 0 R 18 0 R 19 0 R 20 0 R 21 0 R 22 0 R 23 0 R 24 0 R 25 0 R 26 0 R 27 0 R 28 0 R]
endobj
14 0 obj
<>/Border[0 0 0]/Dest(Rpone.0185812.ref001)>>
endobj
15 0 obj
<>/Border[0 0 0]/Dest(Rpone.0185812.ref002)>>
endobj
16 0 obj
<>/Border[0 0 0]/Dest(Rpone.0185812.ref003)>>
endobj
17 0 obj
<>/Border[0 0 0]/Dest(Rpone.0185812.ref004)>>
endobj
18 0 obj
<>/Border[0 0 0]/Dest(Rpone.0185812.ref005)>>
endobj
19 0 obj
<>/Border[0 0 0]/Dest(Rpone.0185812.ref006)>>
endobj
20 0 obj
<>/Border[0 0 0]/Dest(Rpone.0185812.ref007)>>
endobj
21 0 obj
<>/Border[0 0 0]/Dest(Rpone.0185812.ref008)>>
endobj
22 0 obj
<>/Border[0 0 0]/Dest(Rpone.0185812.ref009)>>
endobj
23 0 obj
<>/Border[0 0 0]/Dest(Rpone.0185812.ref010)>>
endobj
24 0 obj
<>/Border[0 0 0]/Dest(Rpone.0185812.ref011)>>
endobj
25 0 obj
<>/Border[0 0 0]/Dest(Rpone.0185812.ref012)>>
endobj
26 0 obj
<>/Border[0 0 0]/Dest(Rpone.0185812.ref013)>>
endobj
27 0 obj
<>/Border[0 0 0]/Dest(Rpone.0185812.ref014)>>
endobj
28 0 obj
<>/Border[0 0 0]/A 29 0 R>>
endobj
29 0 obj
<>
endobj
13 0 obj
[30 0 R 31 0 R 32 0 R 33 0 R 34 0 R 35 0 R 36 0 R 37 0 R 38 0 R 39 0 R 40 0 R 41 0 R 42 0 R 43 0 R 44 0 R 45 0 R 46 0 R 47 0 R 48 0 R]
endobj
30 0 obj
<>stream
q
0.45 0.36 0.35 0.01 k
0 w
575.9997 602.3279 m
199.9998 602.3279 l
199.9998 602.8279 l
575.9997 602.8279 l
f*
0.83 0.64 0.02 0 k
457.6819 517.663 m
462.4441 517.663 l
h
f*
404.1071 504.6803 m
408.8693 504.6803 l
h
f*
359.6598 465.6756 m
364.422 465.6756 l
h
f*
512.2772 452.6929 m
516.9827 452.6929 l
h
f*
488.3528 439.6535 m
493.115 439.6535 l
h
f*
339.0236 413.6882 m
343.7858 413.6882 l
h
f*
268.7811 400.6488 m
273.4866 400.6488 l
h
f*
275.7543 400.6488 m
280.5165 400.6488 l
h
f*
319.3512 387.6661 m
324.1134 387.6661 l
h
f*
326.3811 387.6661 m
335.9055 387.6661 l
h
f*
393.789 361.6441 m
403.3134 361.6441 l
h
f*
548.3906 361.6441 m
557.915 361.6441 l
h
f*
420.0378 335.6787 m
429.5055 335.6787 l
h
f*
222.463 179.4898 m
231.9307 179.4898 l
h
f*
0 g
1 j
1 J
11.4998 0 0 11.4998 200.0125 706.3937 cm
BT
/F2 1 Tf
1 TL
-0.0035 Tc
0 0 Td
(Discussion)Tj
ET
Q
q
1 j
1 J
0 w
9.5 0 0 9.5 200.0125 689.3858 cm
BT
/F0 1 Tf
1 TL
-0.0042 Tc
0 0 Td
(This)Tj
2.0886 0 Td
(study)Tj
2.59 0 Td
(examines)Tj
4.4519 0 Td
(the)Tj
1.5933 0 Td
(effect)Tj
2.6497 0 Td
(of)Tj
1.0443 0 Td
(a)Tj
0.7698 0 Td
(simple)Tj
3.0734 0 Td
(reminder)Tj
4.1177 0 Td
(in)Tj
0.9846 0 Td
(absence)Tj
3.9566 0 Td
(of)Tj
1.0503 0 Td
(other)Tj
2.4706 0 Td
(interventions,)Tj
6.0989 0 Td
(and)Tj
-36.9397 -1.474 Td
(provides)Tj
3.9505 0 Td
(an)Tj
1.3189 0 Td
(example)Tj
3.9565 0 Td
(of)Tj
1.0444 0 Td
(an)Tj
1.3188 0 Td
(effective)Tj
3.9089 0 Td
(non-interruptive)Tj
7.0776 0 Td
(decision)Tj
3.8372 0 Td
(support)Tj
3.5209 0 Td
(intervention.)Tj
ET
Q
q
1 j
1 J
0 w
11.4998 0 0 11.4998 200.0125 646.8094 cm
BT
/F2 1 Tf
1 TL
-0.0035 Tc
0 0 Td
(Conclusion)Tj
ET
Q
q
1 j
1 J
0 w
9.5 0 0 9.5 200.0125 629.8015 cm
BT
/F0 1 Tf
1 TL
-0.0042 Tc
0 0 Td
(A)Tj
0.8832 0 Td
(simple)Tj
3.0733 0 Td
(email)Tj
2.578 0 Td
(reminder)Tj
4.1177 0 Td
(improved)Tj
4.2848 0 Td
(the)Tj
1.5993 0 Td
(number)Tj
3.5746 0 Td
(and)Tj
1.862 0 Td
(timeliness)Tj
4.613 0 Td
(of)Tj
1.0503 0 Td
(letters)Tj
2.9122 0 Td
(from)Tj
2.202 0 Td
(the)Tj
1.5994 0 Td
(outpatient)Tj
-34.3498 -1.468 Td
(department)Tj
5.2276 0 Td
(to)Tj
1.0444 0 Td
(the)Tj
1.5933 0 Td
(general)Tj
3.509 0 Td
(practitioner,)Tj
5.3828 0 Td
(and)Tj
1.8679 0 Td
(was)Tj
1.9813 0 Td
(viewed)Tj
3.2881 0 Td
(as)Tj
1.2652 0 Td
(a)Tj
0.7698 0 Td
(useful)Tj
2.8585 0 Td
(service)Tj
3.3479 0 Td
(by)Tj
1.2651 0 Td
(its)Tj
1.2115 0 Td
(users.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 548.7307 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Introduction)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 531.7228 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(Letters)Tj
2.931 0 Td
(from)Tj
2.2053 0 Td
(the)Tj
1.474 0 Td
(hospital)Tj
3.3789 0 Td
(doctor)Tj
2.8516 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4684 0 Td
(general)Tj
3.1351 0 Td
(practitioner)Tj
4.9436 0 Td
(\(GP\))Tj
2.177 0 Td
(are)Tj
1.4513 0 Td
(the)Tj
1.4683 0 Td
(main)Tj
2.2904 0 Td
(channel)Tj
3.3676 0 Td
(of)Tj
1.0148 0 Td
(com-)Tj
-35.1834 -1.2982 Td
(munication)Tj
4.8585 0 Td
(between)Tj
3.5319 0 Td
(the)Tj
1.4684 0 Td
(hospital)Tj
3.3789 0 Td
(and)Tj
1.7291 0 Td
(the)Tj
1.4683 0 Td
(primary)Tj
3.4583 0 Td
(care)Tj
1.8708 0 Td
(provider)Tj
3.6624 0 Td
([)Tj
0.83 0.64 0.02 0 k
(1)Tj
0 g
(].)Tj
1.5987 0 Td
(In)Tj
1.1112 0 Td
(the)Tj
1.4683 0 Td
(Netherlands,)Tj
5.3404 0 Td
(the)Tj
-34.9452 -1.2983 Td
(GP)Tj
1.491 0 Td
(is)Tj
0.8504 0 Td
(the)Tj
1.4683 0 Td
(central)Tj
2.965 0 Td
(coordinator)Tj
4.9833 0 Td
(for)Tj
1.389 0 Td
(the)Tj
1.4683 0 Td
(patient's)Tj
3.583 0 Td
(care)Tj
1.8708 0 Td
([)Tj
0.83 0.64 0.02 0 k
(2)Tj
0 g
(],)Tj
1.6044 0 Td
(and)Tj
1.7291 0 Td
(thus)Tj
1.9333 0 Td
(it)Tj
0.788 0 Td
(is)Tj
0.8447 0 Td
(important)Tj
4.2803 0 Td
(that)Tj
1.7801 0 Td
(the)Tj
1.4684 0 Td
(GP)Tj
-34.4974 -1.3039 Td
(remains)Tj
3.4412 0 Td
(informed)Tj
3.9741 0 Td
(about)Tj
2.4945 0 Td
(the)Tj
1.4683 0 Td
(care)Tj
1.8766 0 Td
(the)Tj
1.4683 0 Td
(patient)Tj
3.0047 0 Td
(receives)Tj
3.3676 0 Td
(at)Tj
0.9524 0 Td
(the)Tj
1.474 0 Td
(hospital,)Tj
3.6 0 Td
(whether)Tj
3.4752 0 Td
(as)Tj
1.0148 0 Td
(an)Tj
1.2076 0 Td
(inpatient)Tj
3.821 0 Td
(or)Tj
-36.6403 -1.2983 Td
(outpatient.)Tj
4.5637 0 Td
(Poor)Tj
2.1657 0 Td
(communication)Tj
6.6103 0 Td
(between)Tj
3.5263 0 Td
(the)Tj
1.474 0 Td
(hospital)Tj
3.3789 0 Td
(and)Tj
1.7291 0 Td
(the)Tj
1.4683 0 Td
(GP)Tj
1.4967 0 Td
(at)Tj
0.9524 0 Td
(discharge)Tj
4.0195 0 Td
(has)Tj
1.5421 0 Td
(been)Tj
2.1203 0 Td
(asso-)Tj
-35.0473 -1.2982 Td
(ciated)Tj
2.5908 0 Td
(with)Tj
2.0012 0 Td
(higher)Tj
2.8007 0 Td
(rates)Tj
2.1089 0 Td
(of)Tj
1.0148 0 Td
(readmission)Tj
5.108 0 Td
([)Tj
0.83 0.64 0.02 0 k
(3)Tj
0 g
(],)Tj
1.5987 0 Td
(and)Tj
1.7292 0 Td
(clinicians)Tj
4.0081 0 Td
(recognize)Tj
4.0649 0 Td
(good)Tj
2.228 0 Td
(communication)Tj
-29.2533 -1.2983 Td
(between)Tj
3.5262 0 Td
(the)Tj
1.4684 0 Td
(hospital)Tj
3.3788 0 Td
(and)Tj
1.7348 0 Td
(the)Tj
1.4684 0 Td
(GP)Tj
1.491 0 Td
(as)Tj
1.0148 0 Td
(an)Tj
1.2019 0 Td
(important)Tj
4.2859 0 Td
(component)Tj
4.8132 0 Td
(of)Tj
1.0148 0 Td
(patient)Tj
3.0047 0 Td
(safety)Tj
2.4832 0 Td
([)Tj
0.83 0.64 0.02 0 k
(4)Tj
0 g
(].)Tj
1.5987 0 Td
(However,)Tj
4.0762 0 Td
(in)Tj
-36.561 -1.3039 Td
(spite)Tj
2.0862 0 Td
(of)Tj
1.0148 0 Td
(this)Tj
1.6725 0 Td
(recognition,)Tj
5.0739 0 Td
(letters)Tj
2.6419 0 Td
(to)Tj
1.0262 0 Td
(the)Tj
1.4683 0 Td
(GP)Tj
1.4967 0 Td
(are)Tj
1.4456 0 Td
(often)Tj
2.2847 0 Td
(delayed)Tj
3.2599 0 Td
(or)Tj
1.0998 0 Td
(forgotten)Tj
3.9231 0 Td
([)Tj
0.83 0.64 0.02 0 k
(5)Tj
0 g
(].)Tj
-27.2974 -1.2983 Td
(Computerized)Tj
5.981 0 Td
(clinical)Tj
3.0784 0 Td
(decision)Tj
3.5433 0 Td
(support)Tj
3.3222 0 Td
(can)Tj
1.6271 0 Td
(be)Tj
1.1452 0 Td
(defined)Tj
3.2314 0 Td
(as)Tj
1.0148 0 Td
(any)Tj
1.6555 0 Td
(computerized)Tj
5.7372 0 Td
(system)Tj
2.9424 0 Td
(which)Tj
-34.4747 -1.2982 Td
(helps)Tj
2.296 0 Td
(in)Tj
1.0318 0 Td
(making)Tj
3.2542 0 Td
(clinical)Tj
3.0727 0 Td
(decisions)Tj
3.9061 0 Td
([)Tj
0.83 0.64 0.02 0 k
(6)Tj
0 g
(],)Tj
1.6044 0 Td
(including)Tj
4.0422 0 Td
(assistance)Tj
4.1329 0 Td
(with)Tj
1.9956 0 Td
(communication)Tj
6.6103 0 Td
(and)Tj
1.7291 0 Td
(docu-)Tj
-33.6753 -1.304 Td
(mentation)Tj
4.3653 0 Td
(tasks)Tj
2.1713 0 Td
([)Tj
0.83 0.64 0.02 0 k
(7)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(8)Tj
0 g
(].)Tj
2.3017 0 Td
(Automated)Tj
4.7395 0 Td
(reminders)Tj
4.3313 0 Td
(have)Tj
2.0636 0 Td
(been)Tj
2.1203 0 Td
(shown)Tj
2.846 0 Td
(to)Tj
1.0261 0 Td
(be)Tj
1.1509 0 Td
(effective)Tj
3.5093 0 Td
(in)Tj
1.0374 0 Td
(supporting)Tj
-31.6627 -1.2982 Td
(clinical)Tj
3.0727 0 Td
(documentation)Tj
6.3552 0 Td
(tasks)Tj
2.1713 0 Td
([)Tj
0.83 0.64 0.02 0 k
(9)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(10)Tj
0 g
(],)Tj
2.7723 0 Td
(but)Tj
1.5534 0 Td
(thus)Tj
1.9389 0 Td
(far)Tj
1.3096 0 Td
(have)Tj
2.0636 0 Td
(not)Tj
1.5704 0 Td
(been)Tj
2.1259 0 Td
(applied)Tj
3.1521 0 Td
(to)Tj
1.0262 0 Td
(help)Tj
1.9332 0 Td
(doctors)Tj
3.2145 0 Td
(identify)Tj
-34.2593 -1.2983 Td
(patients)Tj
3.3675 0 Td
(for)Tj
1.3833 0 Td
(whom)Tj
2.7609 0 Td
(letters)Tj
2.6419 0 Td
(need)Tj
2.143 0 Td
(to)Tj
1.0261 0 Td
(be)Tj
1.1509 0 Td
(written)Tj
3.1124 0 Td
(and)Tj
1.7291 0 Td
(ensure)Tj
2.8743 0 Td
(that)Tj
1.7802 0 Td
(the)Tj
1.4683 0 Td
(letters)Tj
2.6419 0 Td
(are)Tj
1.4513 0 Td
(sent)Tj
1.8482 0 Td
(in)Tj
1.0375 0 Td
(a)Tj
0.6519 0 Td
(timely)Tj
-33.0687 -1.3039 Td
(manner.)Tj
3.5886 0 Td
(Although)Tj
4.0025 0 Td
(alerts)Tj
2.3584 0 Td
(which)Tj
2.6475 0 Td
(are)Tj
1.4514 0 Td
(interruptive)Tj
4.9889 0 Td
([)Tj
0.83 0.64 0.02 0 k
(11)Tj
0 g
(])Tj
1.8482 0 Td
(and)Tj
1.7348 0 Td
(require)Tj
3.1067 0 Td
(a)Tj
0.6577 0 Td
(reason)Tj
2.8629 0 Td
(for)Tj
1.389 0 Td
(dismissal)Tj
3.8608 0 Td
([)Tj
0.83 0.64 0.02 0 k
(12)Tj
0 g
(])Tj
-34.4974 -1.2983 Td
(have)Tj
2.0579 0 Td
(been)Tj
2.126 0 Td
(shown)Tj
2.8459 0 Td
(to)Tj
1.0262 0 Td
(be)Tj
1.1508 0 Td
(more)Tj
2.3414 0 Td
(effective)Tj
3.5093 0 Td
(than)Tj
2.0296 0 Td
(alerts)Tj
2.3527 0 Td
(without)Tj
3.3279 0 Td
(these)Tj
2.2563 0 Td
(characteristics,)Tj
6.1285 0 Td
(interruption)Tj
-31.1525 -1.2982 Td
(also)Tj
1.7688 0 Td
(has)Tj
1.542 0 Td
(the)Tj
1.4683 0 Td
(potential)Tj
3.7587 0 Td
(to)Tj
1.0262 0 Td
(negatively)Tj
4.2349 0 Td
(impact)Tj
2.982 0 Td
(patient)Tj
3.0048 0 Td
(care)Tj
1.8765 0 Td
([)Tj
0.83 0.64 0.02 0 k
(13)Tj
0 g
(].)Tj
2.0749 0 Td
(Thus,)Tj
2.4718 0 Td
(the)Tj
1.4684 0 Td
(objective)Tj
3.7813 0 Td
(of)Tj
1.0148 0 Td
(this)Tj
1.6781 0 Td
(study)Tj
-34.1515 -1.2983 Td
(was)Tj
1.6951 0 Td
(to)Tj
1.0261 0 Td
(develop)Tj
3.3222 0 Td
(and)Tj
1.7291 0 Td
(evaluate)Tj
3.4639 0 Td
(a)Tj
0.652 0 Td
(non-interruptive)Tj
6.9448 0 Td
(computerized)Tj
5.7373 0 Td
(clinical)Tj
3.0784 0 Td
(decision)Tj
3.5433 0 Td
(support)Tj
3.3222 0 Td
(inter-)Tj
-34.5144 -1.3039 Td
(vention)Tj
3.2654 0 Td
(to)Tj
1.0262 0 Td
(improve)Tj
3.5829 0 Td
(the)Tj
1.4684 0 Td
(number)Tj
3.4185 0 Td
(and)Tj
1.7292 0 Td
(timeliness)Tj
4.2349 0 Td
(of)Tj
1.0148 0 Td
(letters)Tj
2.6419 0 Td
(sent)Tj
1.8538 0 Td
(to)Tj
1.0262 0 Td
(the)Tj
1.4683 0 Td
(GP)Tj
1.491 0 Td
(from)Tj
2.2053 0 Td
(the)Tj
1.4741 0 Td
(hospital's)Tj
3.9514 0 Td
(out-)Tj
-35.8523 -1.2983 Td
(patient)Tj
3.0047 0 Td
(clinic.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 269.1779 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Methods)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 252.17 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(The)Tj
1.7801 0 Td
(Medical)Tj
3.4356 0 Td
(Ethics)Tj
2.6645 0 Td
(Committee)Tj
4.7452 0 Td
(at)Tj
0.9524 0 Td
(our)Tj
1.6214 0 Td
(institution)Tj
4.4107 0 Td
(reviewed)Tj
3.7984 0 Td
(the)Tj
1.4683 0 Td
(plan)Tj
1.9673 0 Td
(for)Tj
1.3833 0 Td
(this)Tj
1.6724 0 Td
(study)Tj
2.3924 0 Td
(and)Tj
1.7292 0 Td
(deter-)Tj
-34.0212 -1.2982 Td
(mined)Tj
2.8062 0 Td
(it)Tj
0.7824 0 Td
(was)Tj
1.7008 0 Td
(exempt)Tj
3.1691 0 Td
(from)Tj
2.2053 0 Td
(the)Tj
1.4684 0 Td
(need)Tj
2.1429 0 Td
(for)Tj
1.389 0 Td
(ethics)Tj
2.5172 0 Td
(committee)Tj
4.5013 0 Td
(review.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 210.5574 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Setting)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 193.6062 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(The)Tj
1.7801 0 Td
(study)Tj
2.3924 0 Td
(took)Tj
2.0296 0 Td
(place)Tj
2.262 0 Td
(in)Tj
1.0375 0 Td
(a)Tj
0.652 0 Td
(tertiary-care,)Tj
5.3688 0 Td
(university)Tj
4.1896 0 Td
(medical)Tj
3.3618 0 Td
(center)Tj
2.7099 0 Td
(seeing)Tj
2.7099 0 Td
(56,000)Tj
2.8233 0 Td
(patients)Tj
3.3676 0 Td
(per)Tj
-34.6845 -1.3039 Td
(year)Tj
1.9048 0 Td
([)Tj
0.83 0.64 0.02 0 k
(14)Tj
0 g
(].)Tj
2.075 0 Td
(The)Tj
1.7801 0 Td
(general)Tj
3.1351 0 Td
(internal)Tj
3.3562 0 Td
(medicine)Tj
3.9231 0 Td
(and)Tj
1.7292 0 Td
(geriatric)Tj
3.5376 0 Td
(medicine)Tj
3.9231 0 Td
(outpatient)Tj
4.3426 0 Td
(clinics)Tj
2.7553 0 Td
(agreed)Tj
2.863 0 Td
(to)Tj
-35.3251 -1.2982 Td
(participate)Tj
4.473 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.4683 0 Td
(trial.)Tj
2.0636 0 Td
(Together,)Tj
4.0762 0 Td
(these)Tj
2.2507 0 Td
(clinics)Tj
2.761 0 Td
(are)Tj
1.4456 0 Td
(staffed)Tj
2.8403 0 Td
(by)Tj
1.1849 0 Td
(11)Tj
1.1679 0 Td
(staff)Tj
1.8878 0 Td
(doctors)Tj
3.2202 0 Td
(and)Tj
1.7291 0 Td
(5)Tj
0.6973 0 Td
(to)Tj
1.0205 0 Td
(7)Tj
0.6973 0 Td
(resi-)Tj
-34.0155 -1.2983 Td
(dents,)Tj
2.6021 0 Td
(and)Tj
1.7292 0 Td
(see)Tj
1.4286 0 Td
(approximately)Tj
5.9754 0 Td
(4000)Tj
2.126 0 Td
(patients)Tj
3.3675 0 Td
(per)Tj
1.5307 0 Td
(year.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 125.9716 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Intervention)Tj
5.3811 0 Td
(design)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 109.0204 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(We)Tj
1.61 0 Td
(planned)Tj
3.4639 0 Td
(to)Tj
1.0262 0 Td
(develop)Tj
3.3165 0 Td
(and)Tj
1.7348 0 Td
(perform)Tj
3.5149 0 Td
(a)Tj
0.6576 0 Td
(patient-specific,)Tj
6.5537 0 Td
(email-based)Tj
5.0116 0 Td
(decision)Tj
3.5433 0 Td
(support)Tj
3.3222 0 Td
(interven-)Tj
-33.7547 -1.3039 Td
(tion.)Tj
2.0636 0 Td
(To)Tj
1.3379 0 Td
(determine)Tj
4.3256 0 Td
(the)Tj
1.4684 0 Td
(content,)Tj
3.4922 0 Td
(format,)Tj
3.1635 0 Td
(timing,)Tj
3.1124 0 Td
(and)Tj
1.7291 0 Td
(interaction)Tj
4.6091 0 Td
(options)Tj
3.2258 0 Td
(for)Tj
1.389 0 Td
(the)Tj
1.4683 0 Td
(intervention,)Tj
-31.3849 -1.2982 Td
(we)Tj
1.3266 0 Td
(conducted)Tj
4.4276 0 Td
(semi-structured)Tj
6.5707 0 Td
(interviews)Tj
4.32 0 Td
(consisting)Tj
4.2689 0 Td
(of)Tj
1.0148 0 Td
(three)Tj
2.2621 0 Td
(questions)Tj
4.0251 0 Td
(pertaining)Tj
4.3597 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 204.0377 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Email)Tj
2.6787 0 Td
(interven)Tj
3.4867 0 Td
(tion)Tj
1.8 0 Td
(to)Tj
1.0417 0 Td
(improve)Tj
3.7134 0 Td
(sending)Tj
3.6567 0 Td
(letters)Tj
2.8914 0 Td
(from)Tj
2.1969 0 Td
(a)Tj
0.7653 0 Td
(hospital)Tj
3.593 0 Td
(outpatient)Tj
4.5354 0 Td
(clinic:)Tj
2.6646 0 Td
(Pair-ran)Tj
3.4867 0 Td
(domized)Tj
3.9402 0 Td
(controll)Tj
3.1535 0 Td
(ed)Tj
1.3111 0 Td
(trial)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
81.5811 34.9228 m
237.8835 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8198 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.01858)Tj
4.089 0 Td
(12)Tj
0 g
2.0906 0 Td
(October)Tj
3.7276 0 Td
(23,)Tj
1.5874 0 Td
(2017)Tj
33.5908 0 Td
(2)Tj
0.7654 0 Td
(/)Tj
0.496 0 Td
(13)Tj
/F8 1 Tf
-0.025 Tc
-66.402 84.0904 Td
(Netherland)Tj
4.0252 0 Td
(s)Tj
0.6449 0 Td
(Organization)Tj
4.8543 0 Td
(for)Tj
1.2544 0 Td
(Health)Tj
2.5724 0 Td
(Researc)Tj
2.9977 0 Td
(h)Tj
0.6945 0 Td
(and)Tj
-17.0434 -1.3748 Td
(Developmen)Tj
4.6417 0 Td
(t)Tj
0.4748 0 Td
(\(ZonMW\))Tj
3.8127 0 Td
(grant)Tj
2.1543 0 Td
(#31102)Tj
2.8347 0 Td
(0302)Tj
2.1189 0 Td
(to)Tj
0.9496 0 Td
(AA.)Tj
-16.9867 -1.3749 Td
(The)Tj
1.5874 0 Td
(funders)Tj
3.0472 0 Td
(had)Tj
1.5874 0 Td
(no)Tj
1.1693 0 Td
(role)Tj
1.6158 0 Td
(in)Tj
0.8858 0 Td
(study)Tj
2.2607 0 Td
(design,)Tj
2.9055 0 Td
(data)Tj
-15.0591 -1.3748 Td
(collection)Tj
3.7417 0 Td
(and)Tj
1.5874 0 Td
(analysis)Tj
2.9623 0 Td
(,)Tj
0.4464 0 Td
(decision)Tj
3.2882 0 Td
(to)Tj
0.9496 0 Td
(publish,)Tj
3.1465 0 Td
(or)Tj
-16.1221 -1.3748 Td
(preparation)Tj
4.4433 0 Td
(of)Tj
0.9496 0 Td
(the)Tj
1.3677 0 Td
(manuscript.)Tj
/F7 1 Tf
-6.7606 -2.126 Td
(Competing)Tj
4.3795 0 Td
(interests)Tj
3.3307 0 Td
(:)Tj
/F8 1 Tf
0.4819 0 Td
(The)Tj
1.5875 0 Td
(authors)Tj
3.0401 0 Td
(have)Tj
1.963 0 Td
(declared)Tj
-14.7827 -1.3748 Td
(that)Tj
1.6228 0 Td
(no)Tj
1.1693 0 Td
(competing)Tj
4.1599 0 Td
(interests)Tj
ET
endstream
endobj
31 0 obj
<>stream
endstream
endobj
32 0 obj
<>stream
endstream
endobj
33 0 obj
<>stream
endstream
endobj
34 0 obj
<>stream
endstream
endobj
35 0 obj
<>stream
endstream
endobj
36 0 obj
<>stream
endstream
endobj
37 0 obj
<>stream
endstream
endobj
38 0 obj
<>stream
endstream
endobj
39 0 obj
<>stream
endstream
endobj
40 0 obj
<>stream
endstream
endobj
41 0 obj
<>stream
endstream
endobj
42 0 obj
<>stream
endstream
endobj
43 0 obj
<>stream
endstream
endobj
44 0 obj
<>stream
endstream
endobj
45 0 obj
<>stream
endstream
endobj
46 0 obj
<>stream
endstream
endobj
47 0 obj
<>stream
endstream
endobj
48 0 obj
<>stream
BT
10.3394 75.0903 Td
(exist.)Tj
ET
Q
endstream
endobj
49 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 11 0 R/Annots 50 0 R/Contents 51 0 R/TrimBox[0 0 612 792]>>
endobj
50 0 obj
[52 0 R 53 0 R 54 0 R 55 0 R 56 0 R]
endobj
52 0 obj
<>/Border[0 0 0]/A 57 0 R>>
endobj
57 0 obj
<>
endobj
53 0 obj
<>/Border[0 0 0]/Dest(Rpone.0185812.ref015)>>
endobj
54 0 obj
<>/Border[0 0 0]/Dest(Rpone.0185812.ref016)>>
endobj
55 0 obj
<>/Border[0 0 0]/Dest(Rpone.0185812.ref017)>>
endobj
56 0 obj
<>/Border[0 0 0]/A 58 0 R>>
endobj
58 0 obj
<>
endobj
51 0 obj
[59 0 R 60 0 R 61 0 R 62 0 R 63 0 R 64 0 R]
endobj
59 0 obj
<>stream
q
0.83 0.64 0.02 0 k
412.2709 439.5969 m
511.7102 439.5969 l
h
f*
203.4142 198.9354 m
212.9386 198.9354 l
h
f*
316.8 133.9087 m
326.3244 133.9087 l
h
f*
328.5921 133.9087 m
338.1165 133.9087 l
h
f*
0 g
1 j
1 J
0 w
10 0 0 10 200.0125 707.4141 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(following)Tj
3.9798 0 Td
(aspects:)Tj
3.2598 0 Td
(the)Tj
1.474 0 Td
(doctor's)Tj
3.4299 0 Td
(current)Tj
3.1804 0 Td
(workflow)Tj
4.0082 0 Td
(regarding)Tj
4.0932 0 Td
(letters,)Tj
2.8687 0 Td
(the)Tj
1.4683 0 Td
(parameters)Tj
4.6715 0 Td
(they)Tj
1.9275 0 Td
(would)Tj
-34.3613 -1.3039 Td
(like)Tj
1.6497 0 Td
(\(e.g.)Tj
1.8992 0 Td
(how)Tj
1.9389 0 Td
(often)Tj
2.2904 0 Td
(they)Tj
1.9218 0 Td
(wanted)Tj
3.1351 0 Td
(reminders\),)Tj
4.8983 0 Td
(and)Tj
1.7348 0 Td
(what)Tj
2.16 0 Td
(capabilities)Tj
4.6658 0 Td
(and)Tj
1.7347 0 Td
(style)Tj
2.0013 0 Td
(of)Tj
1.0148 0 Td
(user)Tj
1.9049 0 Td
(interface)Tj
-32.9497 -1.2982 Td
(they)Tj
1.9218 0 Td
(would)Tj
2.7156 0 Td
(like)Tj
1.6498 0 Td
(for)Tj
1.3889 0 Td
(controlling)Tj
4.6488 0 Td
(the)Tj
1.4683 0 Td
(content)Tj
3.2712 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(emails.)Tj
2.9934 0 Td
(Interview)Tj
4.0309 0 Td
(subjects)Tj
3.3788 0 Td
(were)Tj
2.126 0 Td
(chosen)Tj
3.0104 0 Td
(by)Tj
-35.087 -1.2983 Td
(purposive)Tj
4.1669 0 Td
(sampling)Tj
3.8777 0 Td
(to)Tj
1.0262 0 Td
(represent)Tj
3.9571 0 Td
(both)Tj
2.0579 0 Td
(staff)Tj
1.8936 0 Td
(doctors)Tj
3.2144 0 Td
(and)Tj
1.7292 0 Td
(residents)Tj
3.804 0 Td
(in)Tj
1.0318 0 Td
(both)Tj
2.0636 0 Td
(departments.)Tj
5.4652 0 Td
(Based)Tj
-34.2876 -1.2983 Td
(on)Tj
1.2755 0 Td
(these)Tj
2.2507 0 Td
(results,)Tj
3.0387 0 Td
(we)Tj
1.3267 0 Td
(developed)Tj
4.2689 0 Td
(a)Tj
0.6576 0 Td
(stand-alone,)Tj
5.1194 0 Td
(open-source)Tj
5.1817 0 Td
(computer)Tj
4.1102 0 Td
(program)Tj
3.7077 0 Td
(to)Tj
1.0204 0 Td
(generate)Tj
-31.9575 -1.3039 Td
(email)Tj
2.4094 0 Td
(reminders.)Tj
4.5581 0 Td
(The)Tj
1.7858 0 Td
(query)Tj
2.5001 0 Td
(to)Tj
1.0262 0 Td
(match)Tj
2.7212 0 Td
(letters)Tj
2.6475 0 Td
(to)Tj
1.0205 0 Td
(patients)Tj
3.3675 0 Td
(was)Tj
1.7008 0 Td
(refined)Tj
3.0728 0 Td
(for)Tj
1.3833 0 Td
(each)Tj
2.0296 0 Td
(participating)Tj
-30.2228 -1.2982 Td
(department)Tj
4.8812 0 Td
(to)Tj
1.0261 0 Td
(minimize)Tj
4.0422 0 Td
(the)Tj
1.474 0 Td
(number)Tj
3.4186 0 Td
(of)Tj
1.0148 0 Td
(false)Tj
1.9672 0 Td
(positive)Tj
3.3165 0 Td
(reminders)Tj
4.337 0 Td
(\(i.e.)Tj
1.7008 0 Td
(a)Tj
0.6519 0 Td
(patient)Tj
3.0104 0 Td
(visit)Tj
1.8652 0 Td
(is)Tj
0.8504 0 Td
(included)Tj
-33.5563 -1.2983 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.474 0 Td
(email,)Tj
2.6362 0 Td
(but)Tj
1.5533 0 Td
(a)Tj
0.652 0 Td
(letter)Tj
2.279 0 Td
(was)Tj
1.7008 0 Td
(already)Tj
3.1124 0 Td
(written)Tj
3.1125 0 Td
(for)Tj
1.3833 0 Td
(that)Tj
1.7801 0 Td
(visit\))Tj
2.2054 0 Td
(and)Tj
1.7347 0 Td
(the)Tj
1.4684 0 Td
(number)Tj
3.4185 0 Td
(of)Tj
1.0148 0 Td
(false)Tj
1.9729 0 Td
(negatives)Tj
-32.5301 -1.3039 Td
(\(i.e.)Tj
1.7007 0 Td
(a)Tj
0.652 0 Td
(letter)Tj
2.2847 0 Td
(is)Tj
0.8447 0 Td
(incorrectly)Tj
4.5581 0 Td
(attributed)Tj
4.1726 0 Td
(to)Tj
1.0261 0 Td
(a)Tj
0.652 0 Td
(patient)Tj
3.0047 0 Td
(visit,)Tj
2.0976 0 Td
(thus)Tj
1.9332 0 Td
(no)Tj
1.2756 0 Td
(reminder)Tj
3.9742 0 Td
(is)Tj
0.8447 0 Td
(generated\).)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 574.696 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Baseline)Tj
4.0016 0 Td
(and)Tj
1.8661 0 Td
(trial)Tj
1.8048 0 Td
(design)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 557.6881 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(The)Tj
1.7801 0 Td
(trial)Tj
1.8368 0 Td
(was)Tj
1.7008 0 Td
(registered)Tj
4.1499 0 Td
(with)Tj
2.0013 0 Td
(the)Tj
1.4683 0 Td
(Netherlands)Tj
5.1193 0 Td
(Trial)Tj
2.1487 0 Td
(Registry)Tj
3.4809 0 Td
(\(NTR3369\).)Tj
5.0003 0 Td
(Due)Tj
1.9049 0 Td
(to)Tj
1.0261 0 Td
(high)Tj
2.0069 0 Td
(between-)Tj
-33.6243 -1.2982 Td
(doctor)Tj
2.8516 0 Td
(variation)Tj
3.8041 0 Td
(in)Tj
1.0374 0 Td
(baseline)Tj
3.4299 0 Td
(performance,)Tj
5.5729 0 Td
(pairwise)Tj
3.5433 0 Td
(randomization)Tj
6.1625 0 Td
(was)Tj
1.7008 0 Td
(used)Tj
2.0579 0 Td
(for)Tj
1.389 0 Td
(the)Tj
1.4683 0 Td
(random-)Tj
-33.0177 -1.2983 Td
(ized)Tj
1.8481 0 Td
(controlled)Tj
4.32 0 Td
(trial.)Tj
2.0636 0 Td
(Baseline)Tj
3.5036 0 Td
(performance)Tj
5.3461 0 Td
(was)Tj
1.7008 0 Td
(measured)Tj
4.1102 0 Td
(as)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(percentage)Tj
4.5468 0 Td
(of)Tj
1.0148 0 Td
(patient)Tj
3.0104 0 Td
(visits)Tj
2.228 0 Td
(to)Tj
-36.1755 -1.3039 Td
(the)Tj
1.4683 0 Td
(outpatient)Tj
4.3426 0 Td
(department)Tj
4.8813 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.474 0 Td
(12)Tj
1.1678 0 Td
(months)Tj
3.2825 0 Td
(prior)Tj
2.2564 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4684 0 Td
(start)Tj
1.9842 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(study)Tj
2.3867 0 Td
(which)Tj
2.6532 0 Td
(did)Tj
1.5421 0 Td
(not)Tj
1.576 0 Td
(have)Tj
2.058 0 Td
(a)Tj
-37.0826 -1.2983 Td
(letter)Tj
2.279 0 Td
(associated)Tj
4.2576 0 Td
(with)Tj
1.9956 0 Td
(the)Tj
1.474 0 Td
(visit)Tj
1.8652 0 Td
(by)Tj
1.1848 0 Td
(90)Tj
1.1679 0 Td
(days)Tj
1.9956 0 Td
(after)Tj
2.0353 0 Td
(the)Tj
1.474 0 Td
(visit.)Tj
2.0919 0 Td
(A)Tj
0.9014 0 Td
(cut-off)Tj
2.9027 0 Td
(of)Tj
1.0148 0 Td
(90)Tj
1.1735 0 Td
(days)Tj
1.9956 0 Td
(was)Tj
1.7008 0 Td
(chosen)Tj
-31.5097 -1.2982 Td
(because,)Tj
3.5432 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(baseline)Tj
3.4299 0 Td
(data)Tj
1.9163 0 Td
(set,)Tj
1.525 0 Td
(fewer)Tj
2.4151 0 Td
(than)Tj
2.0239 0 Td
(10%)Tj
1.9332 0 Td
(of)Tj
1.0148 0 Td
(letters)Tj
2.6419 0 Td
(that)Tj
1.7745 0 Td
(were)Tj
2.1259 0 Td
(not)Tj
1.5704 0 Td
(written)Tj
3.1124 0 Td
(by)Tj
1.1849 0 Td
(90)Tj
1.1679 0 Td
(days)Tj
-33.8851 -1.3039 Td
(after)Tj
2.0352 0 Td
(the)Tj
1.4683 0 Td
(visit)Tj
1.8709 0 Td
(were)Tj
2.1203 0 Td
(ever)Tj
1.8935 0 Td
(written)Tj
3.1125 0 Td
(at)Tj
0.9524 0 Td
(all.)Tj
1.372 0 Td
(Pairs)Tj
2.211 0 Td
(of)Tj
1.0148 0 Td
(doctors)Tj
3.2144 0 Td
(were)Tj
2.1203 0 Td
(assigned)Tj
3.6113 0 Td
(to)Tj
1.0262 0 Td
(one)Tj
1.6951 0 Td
(another)Tj
3.3335 0 Td
(to)Tj
1.0261 0 Td
(mini-)Tj
-34.0778 -1.2983 Td
(mize)Tj
2.1429 0 Td
(the)Tj
1.4684 0 Td
(within-pair)Tj
4.7508 0 Td
(difference)Tj
4.2066 0 Td
(in)Tj
1.0375 0 Td
(this)Tj
1.6724 0 Td
(outcome)Tj
3.7247 0 Td
(measure,)Tj
3.8097 0 Td
(and)Tj
1.7292 0 Td
(one)Tj
1.7007 0 Td
(member)Tj
3.583 0 Td
(of)Tj
1.0148 0 Td
(each)Tj
2.0296 0 Td
(pair)Tj
1.8085 0 Td
(was)Tj
-34.6788 -1.2983 Td
(randomly)Tj
4.1272 0 Td
(selected)Tj
3.3505 0 Td
(to)Tj
1.0205 0 Td
(be)Tj
1.1508 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(intervention)Tj
5.1761 0 Td
(group.)Tj
2.8346 0 Td
(Randomization)Tj
6.4119 0 Td
(was)Tj
1.7008 0 Td
(performed)Tj
4.473 0 Td
(by)Tj
1.1792 0 Td
(SM)Tj
-33.9304 -1.3039 Td
(using)Tj
2.3867 0 Td
(the)Tj
1.4683 0 Td
(random)Tj
3.4299 0 Td
(integer)Tj
3.0161 0 Td
(generator)Tj
4.0648 0 Td
(from)Tj
2.2054 0 Td
(the)Tj
1.4683 0 Td
(website)Tj
0.83 0.64 0.02 0 k
3.1861 0 Td
(https://www.random.org)Tj
0 g
(,)Tj
10.3861 0 Td
(by)Tj
1.1849 0 Td
(first)Tj
1.8028 0 Td
(creat-)Tj
-34.5994 -1.2983 Td
(ing)Tj
1.5023 0 Td
(the)Tj
1.4683 0 Td
(pairs)Tj
2.1714 0 Td
(and)Tj
1.7291 0 Td
(then)Tj
2.0182 0 Td
(assigning)Tj
3.9345 0 Td
(each)Tj
2.0296 0 Td
(pair)Tj
1.8085 0 Td
(a)Tj
0.6576 0 Td
(0)Tj
0.6917 0 Td
(\(first)Tj
2.1486 0 Td
(doctor)Tj
2.8517 0 Td
(in)Tj
1.0374 0 Td
(control)Tj
3.1238 0 Td
(group\))Tj
2.948 0 Td
(or)Tj
1.0998 0 Td
(1)Tj
0.6917 0 Td
(\(first)Tj
2.1486 0 Td
(doctor)Tj
-34.0608 -1.2982 Td
(in)Tj
1.0318 0 Td
(intervention)Tj
5.1817 0 Td
(group\).)Tj
3.1691 0 Td
(Doctors)Tj
3.4242 0 Td
(consisted)Tj
3.9401 0 Td
(of)Tj
1.0148 0 Td
(both)Tj
2.058 0 Td
(staff)Tj
1.8935 0 Td
(doctors)Tj
3.2145 0 Td
(and)Tj
1.7291 0 Td
(residents.)Tj
4.0252 0 Td
(Residents)Tj
4.0535 0 Td
(move)Tj
-34.7355 -1.2983 Td
(to)Tj
1.0261 0 Td
(different)Tj
3.6567 0 Td
(departments)Tj
5.2383 0 Td
(during)Tj
2.9311 0 Td
(their)Tj
2.1089 0 Td
(training,)Tj
3.6453 0 Td
(and)Tj
1.7292 0 Td
(the)Tj
1.4683 0 Td
(new)Tj
1.8765 0 Td
(resident)Tj
3.4413 0 Td
(inherits)Tj
3.2825 0 Td
(the)Tj
1.474 0 Td
(outpatients)Tj
4.6998 0 Td
(of)Tj
-36.578 -1.3039 Td
(his)Tj
1.3719 0 Td
(predecessor.)Tj
5.159 0 Td
(Therefore,)Tj
4.3937 0 Td
(new)Tj
1.8765 0 Td
(doctors)Tj
3.2145 0 Td
(entering)Tj
3.566 0 Td
(the)Tj
1.4683 0 Td
(service)Tj
2.9423 0 Td
(also)Tj
1.7688 0 Td
(kept)Tj
1.9559 0 Td
(the)Tj
1.474 0 Td
(same)Tj
2.2564 0 Td
(pair)Tj
1.8085 0 Td
(assign-)Tj
-33.2558 -1.2983 Td
(ment)Tj
2.3017 0 Td
(as)Tj
1.0091 0 Td
(their)Tj
2.1033 0 Td
(predecessor,)Tj
5.1477 0 Td
(allowing)Tj
3.6113 0 Td
(patients)Tj
3.3619 0 Td
(to)Tj
1.0204 0 Td
(remain)Tj
3.0784 0 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.4627 0 Td
(same)Tj
2.2507 0 Td
(arm)Tj
1.8368 0 Td
(of)Tj
1.0092 0 Td
(the)Tj
1.4626 0 Td
(trial.)Tj
2.058 0 Td
(For)Tj
1.6214 0 Td
(the)Tj
1.4626 0 Td
(pur-)Tj
-35.8296 -1.2982 Td
(poses)Tj
2.3867 0 Td
(of)Tj
1.0148 0 Td
(analysis,)Tj
3.5546 0 Td
(the)Tj
1.4684 0 Td
(new)Tj
1.8765 0 Td
(combination)Tj
5.3461 0 Td
(of)Tj
1.0148 0 Td
(doctors)Tj
3.2145 0 Td
(was)Tj
1.7007 0 Td
(considered)Tj
4.6035 0 Td
(a)Tj
0.6519 0 Td
(new)Tj
1.8766 0 Td
(pair.)Tj
2.0352 0 Td
(For)Tj
1.6271 0 Td
(example,)Tj
3.7757 0 Td
(if)Tj
-36.1471 -1.3039 Td
(Dr.)Tj
1.5533 0 Td
(A)Tj
0.9014 0 Td
(and)Tj
1.7292 0 Td
(Dr.)Tj
1.5533 0 Td
(B)Tj
0.7994 0 Td
(are)Tj
1.4513 0 Td
(a)Tj
0.652 0 Td
(pair,)Tj
2.0353 0 Td
(and)Tj
1.7291 0 Td
(Dr.)Tj
1.5534 0 Td
(B)Tj
0.805 0 Td
(leaves)Tj
2.5625 0 Td
(and)Tj
1.7291 0 Td
(is)Tj
0.8447 0 Td
(replaced)Tj
3.5887 0 Td
(by)Tj
1.1849 0 Td
(Dr.)Tj
1.5477 0 Td
(C,)Tj
1.1111 0 Td
(then)Tj
2.0183 0 Td
(Dr.)Tj
1.5534 0 Td
(A)Tj
0.9014 0 Td
(and)Tj
1.7348 0 Td
(Dr.)Tj
1.5533 0 Td
(C)Tj
-35.0926 -1.2983 Td
(form)Tj
2.2053 0 Td
(a)Tj
0.652 0 Td
(new)Tj
1.8765 0 Td
(pair.)Tj
2.0352 0 Td
(Thus,)Tj
2.4718 0 Td
(the)Tj
1.474 0 Td
(same)Tj
2.2564 0 Td
(doctor)Tj
2.8516 0 Td
(could)Tj
2.4548 0 Td
(be)Tj
1.1509 0 Td
(a)Tj
0.652 0 Td
(member)Tj
3.5829 0 Td
(of)Tj
1.0148 0 Td
(more)Tj
2.3471 0 Td
(than)Tj
2.0239 0 Td
(one)Tj
1.7008 0 Td
(pair)Tj
1.8085 0 Td
(during)Tj
2.931 0 Td
(the)Tj
-35.4895 -1.2983 Td
(trial,)Tj
2.0636 0 Td
(but)Tj
1.5477 0 Td
(only)Tj
1.9785 0 Td
(one)Tj
1.7008 0 Td
(pair)Tj
1.8085 0 Td
(during)Tj
2.9253 0 Td
(any)Tj
1.6611 0 Td
(given)Tj
2.3755 0 Td
(time)Tj
2.0295 0 Td
(period.)Tj
3.0614 0 Td
(A)Tj
0.9015 0 Td
(doctor)Tj
2.8573 0 Td
(was)Tj
1.7007 0 Td
(required)Tj
3.6397 0 Td
(to)Tj
1.0205 0 Td
(stay)Tj
1.7688 0 Td
(on)Tj
1.2756 0 Td
(the)Tj
1.4683 0 Td
(out-)Tj
-35.7843 -1.3039 Td
(patient)Tj
3.0047 0 Td
(clinic)Tj
2.3981 0 Td
(for)Tj
1.3832 0 Td
(at)Tj
0.9525 0 Td
(least)Tj
1.9842 0 Td
(two)Tj
1.7121 0 Td
(consecutive)Tj
4.8756 0 Td
(months)Tj
3.2825 0 Td
(during)Tj
2.9253 0 Td
(the)Tj
1.474 0 Td
(trial)Tj
1.8369 0 Td
(to)Tj
1.0261 0 Td
(be)Tj
1.1509 0 Td
(entered)Tj
3.2314 0 Td
(into)Tj
1.8426 0 Td
(the)Tj
1.4683 0 Td
(analy-)Tj
-34.5484 -1.2983 Td
(sis.)Tj
1.4343 0 Td
(Based)Tj
2.5455 0 Td
(on)Tj
1.2755 0 Td
(this)Tj
1.6725 0 Td
(design,)Tj
3.0387 0 Td
(we)Tj
1.3266 0 Td
(estimated)Tj
4.0762 0 Td
(that)Tj
1.7745 0 Td
(we)Tj
1.3323 0 Td
(would)Tj
2.7099 0 Td
(need)Tj
2.1429 0 Td
(to)Tj
1.0262 0 Td
(continue)Tj
3.7644 0 Td
(the)Tj
1.4683 0 Td
(trial)Tj
1.8368 0 Td
(for)Tj
1.389 0 Td
(6)Tj
0.6917 0 Td
(to)Tj
1.0261 0 Td
(12)Tj
-34.5314 -1.2982 Td
(months)Tj
3.2824 0 Td
(to)Tj
1.0262 0 Td
(include)Tj
3.1804 0 Td
(enough)Tj
3.2202 0 Td
(doctors)Tj
3.2144 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4684 0 Td
(analysis.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 256.0251 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Analysis)Tj
3.8976 0 Td
(of)Tj
1.0441 0 Td
(trial)Tj
1.8095 0 Td
(data)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 239.0173 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(The)Tj
1.7801 0 Td
(main)Tj
2.2904 0 Td
(outcome)Tj
3.7247 0 Td
(measure)Tj
3.5829 0 Td
(was)Tj
1.7008 0 Td
(the)Tj
1.4684 0 Td
(percentage)Tj
4.5467 0 Td
(of)Tj
1.0148 0 Td
(patients)Tj
3.3675 0 Td
(who)Tj
1.9389 0 Td
(visited)Tj
2.8233 0 Td
(the)Tj
1.4683 0 Td
(outpatient)Tj
4.337 0 Td
(clinic)Tj
-34.0438 -1.3039 Td
(during)Tj
2.9253 0 Td
(the)Tj
1.4683 0 Td
(trial)Tj
1.8369 0 Td
(who)Tj
1.9388 0 Td
(had)Tj
1.7122 0 Td
(a)Tj
0.6519 0 Td
(letter)Tj
2.2847 0 Td
(written)Tj
3.1125 0 Td
(within)Tj
2.8119 0 Td
(90)Tj
1.1679 0 Td
(days)Tj
2.0012 0 Td
(of)Tj
1.0148 0 Td
(their)Tj
2.1033 0 Td
(visit.)Tj
2.0976 0 Td
(To)Tj
1.338 0 Td
(analyze)Tj
3.1748 0 Td
(the)Tj
1.4683 0 Td
(clustered,)Tj
-33.1084 -1.2982 Td
(pair-randomized)Tj
6.9958 0 Td
(data,)Tj
2.143 0 Td
(we)Tj
1.3266 0 Td
(chose)Tj
2.4605 0 Td
(a)Tj
0.6576 0 Td
(meta-analytic)Tj
5.6522 0 Td
(approach)Tj
3.9515 0 Td
(as)Tj
1.0148 0 Td
(suggested)Tj
4.0705 0 Td
(by)Tj
1.1849 0 Td
(Thompson)Tj
4.6204 0 Td
(et)Tj
0.9411 0 Td
(al.)Tj
-35.0189 -1.2983 Td
([)Tj
0.83 0.64 0.02 0 k
(15)Tj
0 g
(].)Tj
2.0749 0 Td
(The)Tj
1.7801 0 Td
(data)Tj
1.9163 0 Td
(from)Tj
2.2053 0 Td
(each)Tj
2.0296 0 Td
(pair)Tj
1.8085 0 Td
(of)Tj
1.0148 0 Td
(doctors)Tj
3.2144 0 Td
(is)Tj
0.8504 0 Td
(analyzed)Tj
3.7021 0 Td
(as)Tj
1.0148 0 Td
(if)Tj
0.7766 0 Td
(it)Tj
0.7824 0 Td
(were)Tj
2.126 0 Td
(a)Tj
0.6519 0 Td
(trial)Tj
1.8369 0 Td
(in)Tj
1.0374 0 Td
(the)Tj
1.4684 0 Td
(meta-analysis.)Tj
5.879 0 Td
(We)Tj
-36.1698 -1.3039 Td
(expected)Tj
3.719 0 Td
(variability)Tj
4.2236 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(true)Tj
1.8425 0 Td
(effect,)Tj
2.5908 0 Td
(as)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(intervention)Tj
5.176 0 Td
(could)Tj
2.4491 0 Td
(reasonably)Tj
4.5071 0 Td
(be)Tj
1.1508 0 Td
(expected)Tj
3.7247 0 Td
(to)Tj
1.0262 0 Td
(affect)Tj
-35.3988 -1.2983 Td
(some)Tj
2.33 0 Td
(doctors)Tj
3.2145 0 Td
(more)Tj
2.3414 0 Td
(than)Tj
2.0296 0 Td
(others.)Tj
2.9367 0 Td
(Therefore)Tj
4.1669 0 Td
(a)Tj
0.6519 0 Td
(mixed-effects)Tj
5.5786 0 Td
(model)Tj
2.7439 0 Td
(was)Tj
1.7008 0 Td
(used,)Tj
2.2847 0 Td
(using)Tj
2.3867 0 Td
(a)Tj
0.6577 0 Td
(random-)Tj
-33.0234 -1.2982 Td
(effects)Tj
2.7269 0 Td
(model)Tj
2.7439 0 Td
(with)Tj
1.9956 0 Td
(the)Tj
1.4683 0 Td
(Restricted)Tj
4.2349 0 Td
(Maximum)Tj
4.4504 0 Td
(Likelihood)Tj
4.5241 0 Td
(\(REML\))Tj
3.5206 0 Td
(estimator)Tj
4.0025 0 Td
(and)Tj
1.7291 0 Td
(the)Tj
1.4683 0 Td
(difference)Tj
-32.8646 -1.2983 Td
(in)Tj
1.0318 0 Td
(performance)Tj
5.3517 0 Td
(within)Tj
2.812 0 Td
(each)Tj
2.0296 0 Td
(pair)Tj
1.8085 0 Td
(at)Tj
0.9524 0 Td
(the)Tj
1.4683 0 Td
(time)Tj
2.0296 0 Td
(of)Tj
1.0148 0 Td
(randomization)Tj
6.1625 0 Td
(as)Tj
1.0148 0 Td
(a)Tj
0.652 0 Td
(moderator)Tj
4.4844 0 Td
(variable)Tj
3.3562 0 Td
(\(R)Tj
1.1792 0 Td
(ver-)Tj
-35.3478 -1.3039 Td
(sion)Tj
1.9048 0 Td
(3.1.0,)Tj
2.3187 0 Td
(package)Tj
3.4129 0 Td
(metafor\))Tj
3.7021 0 Td
([)Tj
0.83 0.64 0.02 0 k
(16)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
(17)Tj
0 g
(].)Tj
-10.1423 -1.2983 Td
(As)Tj
1.2699 0 Td
(a)Tj
0.6519 0 Td
(secondary)Tj
4.269 0 Td
(analysis,)Tj
3.5546 0 Td
(we)Tj
1.3266 0 Td
(repeated)Tj
3.6397 0 Td
(the)Tj
1.4683 0 Td
(meta-analysis)Tj
5.6523 0 Td
(with)Tj
1.9955 0 Td
(the)Tj
1.4741 0 Td
(patient)Tj
3.0047 0 Td
(as)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(unit)Tj
1.8652 0 Td
(of)Tj
1.0148 0 Td
(analy-)Tj
-34.8659 -1.2983 Td
(sis)Tj
1.2075 0 Td
(rather)Tj
2.6475 0 Td
(than)Tj
2.0296 0 Td
(the)Tj
1.4684 0 Td
(patient)Tj
3.0047 0 Td
(visit.)Tj
2.0976 0 Td
(Patients)Tj
3.4072 0 Td
(can)Tj
1.6271 0 Td
(visit)Tj
1.8652 0 Td
(more)Tj
2.3414 0 Td
(than)Tj
2.0296 0 Td
(once)Tj
2.126 0 Td
(during)Tj
2.9253 0 Td
(the)Tj
1.4683 0 Td
(study)Tj
2.3925 0 Td
(period,)Tj
3.0557 0 Td
(and)Tj
-35.6936 -1.3039 Td
(may)Tj
1.9275 0 Td
(see)Tj
1.4286 0 Td
(different)Tj
3.6567 0 Td
(doctors.)Tj
3.4413 0 Td
(Each)Tj
2.1713 0 Td
(visit)Tj
1.8708 0 Td
(has)Tj
1.5421 0 Td
(the)Tj
1.4683 0 Td
(potential)Tj
3.7587 0 Td
(to)Tj
1.0262 0 Td
(trigger)Tj
2.8856 0 Td
(a)Tj
0.652 0 Td
(reminder,)Tj
4.1952 0 Td
(and)Tj
1.7348 0 Td
(thus)Tj
1.9332 0 Td
(is)Tj
0.8504 0 Td
(the)Tj
-34.5427 -1.2982 Td
(unit)Tj
1.8595 0 Td
(where)Tj
2.6532 0 Td
(the)Tj
1.4683 0 Td
(intervention)Tj
5.176 0 Td
(has)Tj
1.5421 0 Td
(its)Tj
1.1452 0 Td
(main)Tj
2.2904 0 Td
(effect.)Tj
2.5908 0 Td
(However,)Tj
4.0762 0 Td
(in)Tj
1.0375 0 Td
(terms)Tj
2.4944 0 Td
(of)Tj
1.0148 0 Td
(clinical)Tj
3.0728 0 Td
(relevance,)Tj
4.1952 0 Td
(it)Tj
0.7881 0 Td
(is)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 204.0377 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Email)Tj
2.6787 0 Td
(interven)Tj
3.4867 0 Td
(tion)Tj
1.8 0 Td
(to)Tj
1.0417 0 Td
(improve)Tj
3.7134 0 Td
(sending)Tj
3.6567 0 Td
(letters)Tj
2.8914 0 Td
(from)Tj
2.1969 0 Td
(a)Tj
0.7653 0 Td
(hospital)Tj
3.593 0 Td
(outpatient)Tj
4.5354 0 Td
(clinic:)Tj
2.6646 0 Td
(Pair-ran)Tj
3.4867 0 Td
(domized)Tj
3.9402 0 Td
(controll)Tj
3.1535 0 Td
(ed)Tj
1.3111 0 Td
(trial)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
81.5811 34.9228 m
237.8835 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8198 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.01858)Tj
4.089 0 Td
(12)Tj
0 g
2.0906 0 Td
(October)Tj
3.7276 0 Td
(23,)Tj
1.5874 0 Td
(2017)Tj
33.5908 0 Td
(3)Tj
0.7654 0 Td
(/)Tj
ET
endstream
endobj
60 0 obj
<>stream
endstream
endobj
61 0 obj
<>stream
endstream
endobj
62 0 obj
<>stream
endstream
endobj
63 0 obj
<>stream
endstream
endobj
64 0 obj
<>stream
BT
66.402 0 Td
(13)Tj
ET
Q
endstream
endobj
65 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 11 0 R/Annots 66 0 R/Contents 67 0 R/TrimBox[0 0 612 792]>>
endobj
66 0 obj
[68 0 R 69 0 R 70 0 R 71 0 R 72 0 R 73 0 R 74 0 R 75 0 R]
endobj
68 0 obj
<>/Border[0 0 0]/Dest(Rpone.0185812.g001)>>
endobj
69 0 obj
<>/Border[0 0 0]/Dest(Rpone.0185812.ref018)>>
endobj
70 0 obj
<>/Border[0 0 0]/Dest(Rpone.0185812.ref019)>>
endobj
71 0 obj
<>/Border[0 0 0]/Dest(Rpone.0185812.ref020)>>
endobj
72 0 obj
<>/Border[0 0 0]/Dest(Rpone.0185812.ref021)>>
endobj
73 0 obj
<>/Border[0 0 0]/Dest(Rpone.0185812.s001)>>
endobj
74 0 obj
<>/Border[0 0 0]/Dest(Rpone.0185812.g002)>>
endobj
75 0 obj
<>/Border[0 0 0]/A 76 0 R>>
endobj
76 0 obj
<>
endobj
67 0 obj
[77 0 R 78 0 R 79 0 R 80 0 R 81 0 R 82 0 R 83 0 R 84 0 R 85 0 R 86 0 R 87 0 R]
endobj
77 0 obj
<>stream
q
0.83 0.64 0.02 0 k
533.1402 498.3307 m
552.6992 498.3307 l
h
f*
540.3402 435.6283 m
549.8646 435.6283 l
h
f*
275.2441 396.6236 m
284.7685 396.6236 l
h
f*
401.3858 396.6236 m
410.9102 396.6236 l
h
f*
260.4472 383.6409 m
269.9717 383.6409 l
h
f*
378.7654 383.6409 m
405.0709 383.6409 l
h
f*
377.178 224.9008 m
396.737 224.9008 l
h
f*
0 g
1 j
1 J
0 w
10 0 0 10 200.0125 707.4141 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(more)Tj
2.3414 0 Td
(important)Tj
4.2802 0 Td
(to)Tj
1.0262 0 Td
(ask)Tj
1.508 0 Td
(whether)Tj
3.4809 0 Td
(the)Tj
1.4684 0 Td
(patient)Tj
3.0047 0 Td
(has)Tj
1.542 0 Td
(a)Tj
0.6576 0 Td
(letter)Tj
2.2791 0 Td
(associated)Tj
4.2576 0 Td
(with)Tj
1.9956 0 Td
(their)Tj
2.1089 0 Td
(visit.)Tj
2.092 0 Td
(Thus,)Tj
2.4774 0 Td
(we)Tj
1.3267 0 Td
(also)Tj
-35.8467 -1.3039 Td
(performed)Tj
4.4673 0 Td
(the)Tj
1.4684 0 Td
(analysis)Tj
3.3278 0 Td
(with)Tj
1.9956 0 Td
(the)Tj
1.474 0 Td
(patient)Tj
3.0047 0 Td
(as)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(unit)Tj
1.8652 0 Td
(of)Tj
1.0148 0 Td
(analysis)Tj
3.3222 0 Td
(rather)Tj
2.6475 0 Td
(than)Tj
2.0296 0 Td
(the)Tj
1.4684 0 Td
(patient-visit.)Tj
5.2327 0 Td
(For)Tj
-35.8013 -1.2982 Td
(this)Tj
1.6724 0 Td
(analysis,)Tj
3.5546 0 Td
(patients)Tj
3.3675 0 Td
(were)Tj
2.1203 0 Td
(assigned)Tj
3.6057 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.474 0 Td
(doctor)Tj
2.8517 0 Td
(that)Tj
1.7801 0 Td
(they)Tj
1.9219 0 Td
(saw)Tj
1.7008 0 Td
(on)Tj
1.2756 0 Td
(their)Tj
2.1089 0 Td
(first)Tj
1.8028 0 Td
(visit)Tj
1.8709 0 Td
(during)Tj
2.9253 0 Td
(the)Tj
-35.0586 -1.2983 Td
(trial.)Tj
2.0636 0 Td
(We)Tj
1.6044 0 Td
(also)Tj
1.7688 0 Td
(compared)Tj
4.2462 0 Td
(the)Tj
1.4684 0 Td
(before-after)Tj
4.9039 0 Td
(performance)Tj
5.3518 0 Td
(of)Tj
1.0148 0 Td
(both)Tj
2.0579 0 Td
(the)Tj
1.4683 0 Td
(control)Tj
3.1238 0 Td
(and)Tj
1.7291 0 Td
(intervention)Tj
-30.801 -1.2983 Td
(groups)Tj
2.9706 0 Td
(using)Tj
2.3868 0 Td
(a)Tj
0.652 0 Td
(chi-squared)Tj
4.9436 0 Td
(test.)Tj
1.8255 0 Td
(The)Tj
1.7858 0 Td
(median)Tj
3.2371 0 Td
(number)Tj
3.4186 0 Td
(of)Tj
1.0148 0 Td
(days)Tj
1.9955 0 Td
(between)Tj
3.532 0 Td
(the)Tj
1.4683 0 Td
(visit)Tj
1.8652 0 Td
(date)Tj
1.9049 0 Td
(and)Tj
1.7291 0 Td
(the)Tj
-34.7298 -1.3039 Td
(start)Tj
1.9842 0 Td
(date)Tj
1.8992 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(letter)Tj
2.279 0 Td
(and)Tj
1.7292 0 Td
(the)Tj
1.4683 0 Td
(median)Tj
3.2428 0 Td
(number)Tj
3.4186 0 Td
(of)Tj
1.0148 0 Td
(days)Tj
1.9955 0 Td
(between)Tj
3.532 0 Td
(the)Tj
1.4683 0 Td
(visit)Tj
1.8652 0 Td
(date)Tj
1.9049 0 Td
(and)Tj
1.7291 0 Td
(the)Tj
1.474 0 Td
(date)Tj
1.8992 0 Td
(the)Tj
-35.3931 -1.2982 Td
(letter)Tj
2.279 0 Td
(was)Tj
1.7008 0 Td
(sent)Tj
1.8481 0 Td
(to)Tj
1.0262 0 Td
(the)Tj
1.474 0 Td
(GP)Tj
1.491 0 Td
(was)Tj
1.7008 0 Td
(measured)Tj
4.1045 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(control)Tj
3.1238 0 Td
(and)Tj
1.7291 0 Td
(intervention)Tj
5.176 0 Td
(groups)Tj
2.9707 0 Td
(and)Tj
1.7292 0 Td
(compared)Tj
-32.859 -1.2983 Td
(using)Tj
2.3867 0 Td
(the)Tj
1.4683 0 Td
(Mann-Whitney)Tj
6.4857 0 Td
(U)Tj
0.9524 0 Td
(test.)Tj
1.8255 0 Td
(In)Tj
1.1112 0 Td
(addition,)Tj
3.8211 0 Td
(we)Tj
1.3266 0 Td
(performed)Tj
4.473 0 Td
(a)Tj
0.652 0 Td
(post-hoc)Tj
3.7133 0 Td
(sensitivity)Tj
4.2236 0 Td
(analysis)Tj
3.3222 0 Td
(with)Tj
-35.7616 -1.3039 Td
(the)Tj
1.4683 0 Td
(natural)Tj
3.0784 0 Td
(logarithm)Tj
4.1556 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(ratio)Tj
2.0976 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(number)Tj
3.4186 0 Td
(of)Tj
1.0148 0 Td
(patients)Tj
3.3675 0 Td
(seen)Tj
1.9786 0 Td
(by)Tj
1.1792 0 Td
(the)Tj
1.4683 0 Td
(control)Tj
3.1238 0 Td
(doctor)Tj
2.8516 0 Td
(to)Tj
1.0262 0 Td
(the)Tj
-35.2004 -1.2983 Td
(number)Tj
3.4128 0 Td
(of)Tj
1.0092 0 Td
(patients)Tj
3.3675 0 Td
(seen)Tj
1.9729 0 Td
(by)Tj
1.1792 0 Td
(the)Tj
1.4627 0 Td
(intervention)Tj
5.176 0 Td
(doctor)Tj
2.8516 0 Td
(as)Tj
1.0092 0 Td
(an)Tj
1.1962 0 Td
(additional)Tj
4.2746 0 Td
(moderator)Tj
4.4787 0 Td
(variable)Tj
3.3505 0 Td
(to)Tj
1.0262 0 Td
(con-)Tj
-35.7673 -1.2983 Td
(trol)Tj
1.644 0 Td
(for)Tj
1.3833 0 Td
(workload.)Tj
-1.8311 -1.3039 Td
(The)Tj
1.7858 0 Td
(software)Tj
3.5886 0 Td
(was)Tj
1.6951 0 Td
(written)Tj
3.1124 0 Td
(in)Tj
1.0375 0 Td
(Java)Tj
1.8709 0 Td
(as)Tj
1.0148 0 Td
(open)Tj
2.2166 0 Td
(source)Tj
2.8347 0 Td
(software.)Tj
3.8097 0 Td
(It)Tj
0.8617 0 Td
(gathers)Tj
3.1011 0 Td
(a)Tj
0.652 0 Td
(list)Tj
1.3946 0 Td
(of)Tj
1.0148 0 Td
(patients)Tj
3.3676 0 Td
(with)Tj
1.9955 0 Td
(a)Tj
-36.5496 -1.2982 Td
(recent)Tj
2.7099 0 Td
(or)Tj
1.0941 0 Td
(planned)Tj
3.4696 0 Td
(visit)Tj
1.8652 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4684 0 Td
(outpatient)Tj
4.3426 0 Td
(clinic,)Tj
2.6192 0 Td
(checks)Tj
2.8743 0 Td
(whether)Tj
3.4809 0 Td
(the)Tj
1.4684 0 Td
(patient)Tj
3.0047 0 Td
(has)Tj
1.542 0 Td
(a)Tj
0.6577 0 Td
(letter)Tj
2.279 0 Td
(that)Tj
-33.9021 -1.2983 Td
(matches)Tj
3.5035 0 Td
(to)Tj
1.0262 0 Td
(the)Tj
1.474 0 Td
(visit)Tj
1.8652 0 Td
(\(according)Tj
4.5297 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4684 0 Td
(criteria)Tj
3.0727 0 Td
(set)Tj
1.3039 0 Td
(for)Tj
1.389 0 Td
(each)Tj
2.0296 0 Td
(department\),)Tj
5.4482 0 Td
(and)Tj
1.7291 0 Td
(if)Tj
0.771 0 Td
(not,)Tj
1.8028 0 Td
(marks)Tj
2.6986 0 Td
(the)Tj
-35.138 -1.3039 Td
(patient)Tj
3.0047 0 Td
(as)Tj
1.0148 0 Td
(eligible)Tj
3.067 0 Td
(for)Tj
1.3833 0 Td
(a)Tj
0.6577 0 Td
(reminder.)Tj
4.1952 0 Td
(The)Tj
1.7858 0 Td
(software)Tj
3.583 0 Td
(checks)Tj
2.88 0 Td
(the)Tj
1.4683 0 Td
(agenda,)Tj
3.2768 0 Td
(checks)Tj
2.8743 0 Td
(for)Tj
1.389 0 Td
(letters,)Tj
2.8687 0 Td
(and)Tj
1.7291 0 Td
(then)Tj
-35.1777 -1.2983 Td
(sends)Tj
2.4377 0 Td
(reminders,)Tj
4.5638 0 Td
(so)Tj
1.0885 0 Td
(all)Tj
1.1452 0 Td
(information)Tj
5.074 0 Td
(is)Tj
0.8503 0 Td
(up)Tj
1.2643 0 Td
(to)Tj
1.0261 0 Td
(date)Tj
1.9049 0 Td
(when)Tj
2.4038 0 Td
(the)Tj
1.4683 0 Td
(reminders)Tj
4.3313 0 Td
(are)Tj
1.4513 0 Td
(sent.)Tj
2.075 0 Td
(Timelines)Tj
4.1896 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
-36.2889 -1.2982 Td
(possible)Tj
3.4072 0 Td
(relationships)Tj
5.3517 0 Td
(between)Tj
3.5263 0 Td
(the)Tj
1.474 0 Td
(visit)Tj
1.8652 0 Td
(date)Tj
1.9049 0 Td
(and)Tj
1.7291 0 Td
(the)Tj
1.4683 0 Td
(reminder)Tj
3.9742 0 Td
(date)Tj
1.9049 0 Td
(are)Tj
1.4456 0 Td
(illustrated)Tj
4.2236 0 Td
(in)Tj
0.83 0.64 0.02 0 k
1.0375 0 Td
(Fig)Tj
1.4797 0 Td
(1)Tj
0 g
(.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 466.696 cm
BT
/F0 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(User)Tj
2.3102 0 Td
(satisfaction)Tj
5.1638 0 Td
(survey)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 449.6881 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(To)Tj
1.3379 0 Td
(assess)Tj
2.5228 0 Td
(the)Tj
1.4684 0 Td
(users')Tj
2.4774 0 Td
(perception)Tj
4.5184 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(system,)Tj
3.1635 0 Td
(two)Tj
1.7121 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(researchers)Tj
4.7112 0 Td
(\(SM)Tj
1.9275 0 Td
(and)Tj
1.7292 0 Td
(DS\))Tj
1.7744 0 Td
(constructed)Tj
-32.309 -1.2982 Td
(a)Tj
0.6519 0 Td
(survey)Tj
2.812 0 Td
(based)Tj
2.4774 0 Td
(on)Tj
1.2756 0 Td
(the)Tj
1.4683 0 Td
(Information)Tj
5.1477 0 Td
(Systems)Tj
3.4129 0 Td
(Success)Tj
3.2145 0 Td
(Model)Tj
2.8176 0 Td
(\(DeLone/McLean)Tj
7.3304 0 Td
(model\))Tj
3.084 0 Td
([)Tj
0.83 0.64 0.02 0 k
(18)Tj
0 g
(].)Tj
2.075 0 Td
(The)Tj
-35.7673 -1.2983 Td
(constructs)Tj
4.3369 0 Td
(from)Tj
2.2054 0 Td
(this)Tj
1.6781 0 Td
(model)Tj
2.7439 0 Td
(that)Tj
1.7745 0 Td
(were)Tj
2.1259 0 Td
(relevant)Tj
3.4186 0 Td
(to)Tj
1.0261 0 Td
(this)Tj
1.6725 0 Td
(intervention)Tj
5.176 0 Td
(were)Tj
2.126 0 Td
(identified)Tj
4.0592 0 Td
(and)Tj
1.7291 0 Td
(instanti-)Tj
-34.0722 -1.3039 Td
(ated)Tj
1.9048 0 Td
(with)Tj
1.9956 0 Td
(questions)Tj
4.0195 0 Td
(from)Tj
2.2053 0 Td
(existing)Tj
3.3166 0 Td
(standard)Tj
3.7247 0 Td
(questionnaires:)Tj
6.2872 0 Td
(the)Tj
1.474 0 Td
(IBM)Tj
2.0296 0 Td
(Computer)Tj
4.3483 0 Td
(System)Tj
3.0557 0 Td
(Usabil-)Tj
-34.3613 -1.2983 Td
(ity)Tj
1.2415 0 Td
(Questionnaire)Tj
5.9414 0 Td
([)Tj
0.83 0.64 0.02 0 k
(19)Tj
0 g
(],)Tj
2.0749 0 Td
(the)Tj
1.4741 0 Td
(System)Tj
3.05 0 Td
(Usability)Tj
3.7927 0 Td
(Scale)Tj
2.2224 0 Td
([)Tj
0.83 0.64 0.02 0 k
(20)Tj
0 g
(],)Tj
2.0749 0 Td
(and)Tj
1.7292 0 Td
(the)Tj
1.474 0 Td
(Computer)Tj
4.3483 0 Td
(User)Tj
2.1089 0 Td
(Satisfaction)Tj
-31.5323 -1.2982 Td
(questionnaire)Tj
5.7032 0 Td
([)Tj
0.83 0.64 0.02 0 k
(21)Tj
0 g
(].)Tj
2.075 0 Td
(The)Tj
1.7858 0 Td
(resulting)Tj
3.7247 0 Td
(survey)Tj
2.8176 0 Td
(\(see)Tj
0.83 0.64 0.02 0 k
1.7688 0 Td
(S1)Tj
1.1679 0 Td
(File)Tj
0 g
(\))Tj
2.0239 0 Td
(was)Tj
1.7008 0 Td
(assessed)Tj
3.4696 0 Td
(for)Tj
1.3889 0 Td
(face)Tj
1.7858 0 Td
(validity)Tj
3.1748 0 Td
(and)Tj
1.7292 0 Td
(com-)Tj
-34.316 -1.3039 Td
(pleteness)Tj
3.821 0 Td
(by)Tj
1.1849 0 Td
(two)Tj
1.7064 0 Td
(experts)Tj
3.0785 0 Td
(in)Tj
1.0374 0 Td
(medical)Tj
3.3619 0 Td
(informatics)Tj
4.8075 0 Td
(\(SE)Tj
1.6044 0 Td
(and)Tj
1.7291 0 Td
(AA\).)Tj
2.1544 0 Td
(It)Tj
0.856 0 Td
(was)Tj
1.7008 0 Td
(distributed)Tj
4.5978 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4683 0 Td
(doctors)Tj
-34.1345 -1.2983 Td
(in)Tj
1.0318 0 Td
(the)Tj
1.474 0 Td
(intervention)Tj
5.176 0 Td
(arm)Tj
1.8425 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(trial)Tj
1.8425 0 Td
(as)Tj
1.0148 0 Td
(an)Tj
1.2019 0 Td
(email)Tj
2.4095 0 Td
(to)Tj
1.0261 0 Td
(their)Tj
2.1033 0 Td
(hospital)Tj
3.3789 0 Td
(email)Tj
2.4151 0 Td
(address.)Tj
3.4469 0 Td
(A)Tj
0.9071 0 Td
(paper)Tj
2.4831 0 Td
(version)Tj
-34.2366 -1.2983 Td
(was)Tj
1.6951 0 Td
(also)Tj
1.7688 0 Td
(distributed)Tj
4.5977 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4683 0 Td
(hospital)Tj
3.3789 0 Td
(mail)Tj
1.9843 0 Td
(boxes)Tj
2.4888 0 Td
(for)Tj
1.3833 0 Td
(doctors)Tj
3.2144 0 Td
(who)Tj
1.9389 0 Td
(were)Tj
2.126 0 Td
(still)Tj
1.6384 0 Td
(working)Tj
3.5603 0 Td
(in)Tj
1.0318 0 Td
(our)Tj
1.6271 0 Td
(hospi-)Tj
-34.9396 -1.3039 Td
(tal.)Tj
1.4229 0 Td
(Surveys)Tj
3.2882 0 Td
(returned)Tj
3.7134 0 Td
(in)Tj
1.0374 0 Td
(paper)Tj
2.4832 0 Td
(form)Tj
2.2053 0 Td
(were)Tj
2.1203 0 Td
(anonymous.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 300.0188 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Results)Tj
/F0 1 Tf
0 -1.5023 Td
(Intervention)Tj
5.3811 0 Td
(design)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 264.9826 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(We)Tj
1.61 0 Td
(conducted)Tj
4.4277 0 Td
(interviews)Tj
4.3143 0 Td
(with)Tj
2.0013 0 Td
(a)Tj
0.6519 0 Td
(purposive)Tj
4.1669 0 Td
(sample)Tj
3.0217 0 Td
(of)Tj
1.0148 0 Td
(five)Tj
1.6555 0 Td
(doctors)Tj
3.2144 0 Td
(\(the)Tj
1.8085 0 Td
(heads)Tj
2.4945 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(geriatrics)Tj
-32.8646 -1.2982 Td
(and)Tj
1.7291 0 Td
(internal)Tj
3.3562 0 Td
(medicine)Tj
3.9231 0 Td
(departments,)Tj
5.4652 0 Td
(one)Tj
1.7007 0 Td
(additional)Tj
4.2803 0 Td
(senior)Tj
2.6986 0 Td
(doctor,)Tj
3.0784 0 Td
(and)Tj
1.7291 0 Td
(one)Tj
1.7008 0 Td
(resident)Tj
3.4412 0 Td
(from)Tj
2.2054 0 Td
(each)Tj
-35.3081 -1.2983 Td
(department\).)Tj
5.4481 0 Td
(Based)Tj
2.5455 0 Td
(on)Tj
1.2756 0 Td
(these)Tj
2.2507 0 Td
(interviews,)Tj
4.5467 0 Td
(we)Tj
1.3266 0 Td
(designed)Tj
3.7644 0 Td
(an)Tj
1.2019 0 Td
(intervention)Tj
5.176 0 Td
(consisting)Tj
4.269 0 Td
(of)Tj
1.0148 0 Td
(a)Tj
0.6519 0 Td
(monthly,)Tj
-33.4712 -1.3039 Td
(plain-text)Tj
4.0705 0 Td
(email)Tj
2.4094 0 Td
(formatted)Tj
4.1839 0 Td
(in)Tj
1.0375 0 Td
(three)Tj
2.2677 0 Td
(sections)Tj
3.4072 0 Td
(\()Tj
0.83 0.64 0.02 0 k
(Fig)Tj
1.8198 0 Td
(2)Tj
0 g
(\).)Tj
1.2586 0 Td
(Hospital)Tj
3.6227 0 Td
(policy)Tj
2.6362 0 Td
(states)Tj
2.3924 0 Td
(that)Tj
1.7802 0 Td
(letters)Tj
2.6418 0 Td
(should)Tj
2.9197 0 Td
(be)Tj
-36.4476 -1.2983 Td
(sent)Tj
1.8481 0 Td
(for)Tj
1.389 0 Td
(new)Tj
2.2677 0 Td
(patients)Tj
3.7587 0 Td
(\(the)Tj
1.8085 0 Td
(patient's)Tj
3.583 0 Td
(first)Tj
1.8085 0 Td
(visit)Tj
1.8708 0 Td
(to)Tj
1.0205 0 Td
(the)Tj
1.474 0 Td
(department\))Tj
5.2214 0 Td
(within)Tj
2.8119 0 Td
(2)Tj
0.6973 0 Td
(months)Tj
3.2825 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(visit.)Tj
-35.3251 -1.2982 Td
(The)Tj
1.7801 0 Td
(policy)Tj
2.6362 0 Td
(for)Tj
1.389 0 Td
(recheck)Tj
3.3051 0 Td
(patients)Tj
3.3676 0 Td
(varies)Tj
2.5341 0 Td
(per)Tj
1.5307 0 Td
(department;)Tj
5.108 0 Td
(the)Tj
1.4684 0 Td
(departments)Tj
5.244 0 Td
(in)Tj
1.0375 0 Td
(our)Tj
1.6271 0 Td
(study)Tj
2.3867 0 Td
(recom-)Tj
-33.4145 -1.3039 Td
(mend)Tj
2.5398 0 Td
(a)Tj
0.6519 0 Td
(letter)Tj
2.2791 0 Td
(every)Tj
2.3527 0 Td
(2)Tj
0.6917 0 Td
(years)Tj
2.2677 0 Td
(\(internal)Tj
3.6963 0 Td
(medicine\))Tj
4.2633 0 Td
(or)Tj
1.0942 0 Td
(every)Tj
2.347 0 Td
(year)Tj
1.9049 0 Td
(\(geriatrics\).)Tj
4.8075 0 Td
(Because)Tj
3.3959 0 Td
(the)Tj
1.4684 0 Td
(email)Tj
-33.7604 -1.2983 Td
(was)Tj
1.6951 0 Td
(sent)Tj
1.8538 0 Td
(monthly,)Tj
3.8494 0 Td
(reminders)Tj
4.3313 0 Td
(would)Tj
2.7156 0 Td
(be)Tj
1.1509 0 Td
(sent)Tj
1.8481 0 Td
(for)Tj
1.389 0 Td
(new)Tj
1.8765 0 Td
(patients)Tj
3.3676 0 Td
(6)Tj
0.6916 0 Td
(to)Tj
1.0262 0 Td
(10)Tj
1.1735 0 Td
(weeks)Tj
2.6079 0 Td
(after)Tj
2.0352 0 Td
(their)Tj
2.109 0 Td
(visit.)Tj
2.0919 0 Td
(If)Tj
-35.8126 -1.2983 Td
(any)Tj
1.6554 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(sections)Tj
3.4129 0 Td
(had)Tj
1.7064 0 Td
(no)Tj
1.2756 0 Td
(patients)Tj
3.3676 0 Td
(due)Tj
1.7007 0 Td
(for)Tj
1.389 0 Td
(letters,)Tj
2.863 0 Td
(that)Tj
1.7801 0 Td
(section)Tj
3.0501 0 Td
(contained)Tj
4.1952 0 Td
(a)Tj
0.6577 0 Td
(message)Tj
3.5036 0 Td
(that)Tj
1.7801 0 Td
(said)Tj
-34.8205 -1.2982 Td
(Well)Tj
2.4944 0 Td
(done!)Tj
2.4945 0 Td
(No)Tj
1.4627 0 Td
(\(new/recheck\))Tj
5.9754 0 Td
(patients)Tj
3.3675 0 Td
(are)Tj
1.4457 0 Td
(in)Tj
1.0374 0 Td
(need)Tj
2.143 0 Td
(of)Tj
1.0148 0 Td
(letters!)Tj
3.2995 0 Td
(The)Tj
1.7858 0 Td
(subject)Tj
3.0161 0 Td
(line)Tj
1.7064 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(email)Tj
-33.7264 -1.304 Td
(read)Tj
1.9729 0 Td
(letters)Tj
3.0387 0 Td
(due)Tj
2.0919 0 Td
(and)Tj
1.7292 0 Td
(was)Tj
1.6951 0 Td
(the)Tj
1.474 0 Td
(same)Tj
2.2563 0 Td
(for)Tj
1.3833 0 Td
(emails)Tj
2.7723 0 Td
(with)Tj
2.0012 0 Td
(or)Tj
1.0942 0 Td
(without)Tj
3.3335 0 Td
(patients)Tj
3.3676 0 Td
(in)Tj
1.0374 0 Td
(need)Tj
2.143 0 Td
(of)Tj
1.0148 0 Td
(letters.)Tj
2.863 0 Td
(The)Tj
-35.2684 -1.2982 Td
(emails)Tj
2.7722 0 Td
(were)Tj
2.1203 0 Td
(signed)Tj
2.812 0 Td
(Snelle)Tj
2.9763 0 Td
(Cor)Tj
2.1543 0 Td
(\(Cor)Tj
2.8857 0 Td
(alludes)Tj
2.9877 0 Td
(to)Tj
1.0261 0 Td
(correspondence)Tj
6.5934 0 Td
(and)Tj
1.7348 0 Td
(is)Tj
0.8447 0 Td
(a)Tj
0.6519 0 Td
(common)Tj
3.8495 0 Td
(Dutch)Tj
-33.4089 -1.2983 Td
(first)Tj
1.8028 0 Td
(name,)Tj
2.6702 0 Td
(and)Tj
1.7348 0 Td
(snelle)Tj
3.2541 0 Td
(means)Tj
2.8063 0 Td
(fast\).)Tj
2.1657 0 Td
(The)Tj
1.7801 0 Td
(doctors)Tj
3.2145 0 Td
(we)Tj
1.3323 0 Td
(interviewed)Tj
4.9095 0 Td
(did)Tj
1.5421 0 Td
(not)Tj
1.5704 0 Td
(want)Tj
2.1883 0 Td
(a)Tj
0.652 0 Td
(user)Tj
1.9048 0 Td
(interface)Tj
-33.5279 -1.3039 Td
(for)Tj
1.3832 0 Td
(controlling)Tj
4.6488 0 Td
(the)Tj
1.474 0 Td
(content)Tj
3.2655 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4684 0 Td
(reminders,)Tj
4.5581 0 Td
(therefore)Tj
3.855 0 Td
(we)Tj
1.3267 0 Td
(instead)Tj
3.084 0 Td
(added)Tj
2.6589 0 Td
(information)Tj
5.074 0 Td
(about)Tj
-33.8114 -1.2983 Td
(contacting)Tj
4.4333 0 Td
(the)Tj
1.4683 0 Td
(administrator)Tj
5.726 0 Td
(to)Tj
1.0261 0 Td
(the)Tj
1.4684 0 Td
(emails.)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
7.9999 0 0 7.9999 204.0377 745.7952 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(Email)Tj
2.6787 0 Td
(interven)Tj
3.4867 0 Td
(tion)Tj
1.8 0 Td
(to)Tj
1.0417 0 Td
(improve)Tj
3.7134 0 Td
(sending)Tj
3.6567 0 Td
(letters)Tj
2.8914 0 Td
(from)Tj
2.1969 0 Td
(a)Tj
0.7653 0 Td
(hospital)Tj
3.593 0 Td
(outpatient)Tj
4.5354 0 Td
(clinic:)Tj
2.6646 0 Td
(Pair-ran)Tj
3.4867 0 Td
(domized)Tj
3.9402 0 Td
(controll)Tj
3.1535 0 Td
(ed)Tj
1.3111 0 Td
(trial)Tj
ET
Q
q
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
81.5811 34.9228 m
237.8835 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8198 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.01858)Tj
4.089 0 Td
(12)Tj
0 g
2.0906 0 Td
(October)Tj
3.7276 0 Td
(23,)Tj
1.5874 0 Td
(2017)Tj
33.5908 0 Td
(4)Tj
0.7654 0 Td
(/)Tj
ET
endstream
endobj
78 0 obj
<>stream
endstream
endobj
79 0 obj
<>stream
endstream
endobj
80 0 obj
<>stream
endstream
endobj
81 0 obj
<>stream
endstream
endobj
82 0 obj
<>stream
endstream
endobj
83 0 obj
<>stream
endstream
endobj
84 0 obj
<>stream
endstream
endobj
85 0 obj
<>stream
endstream
endobj
86 0 obj
<>stream
endstream
endobj
87 0 obj
<>stream
BT
66.402 0 Td
(13)Tj
ET
Q
endstream
endobj
88 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 11 0 R/Annots 93 0 R/Contents 94 0 R/TrimBox[0 0 612 792]>>
endobj
92 0 obj
<>/ProcSet[/PDF/ImageC]/Properties<>/XObject<>>>/Filter/FlateDecode/Length 112>>stream
h,;0=Ż?(r 6"4f\ܖ3$Z{+-anB&7̂%ZVˬt% n~
k
endstream
endobj
95 0 obj
<>
endobj
96 0 obj
<<>>
endobj
97 0 obj
<>stream
Adobe d
9
s !1AQa"q2B#R3b$r%C4Scs5D'6Tdt&
EFVU(eufv7GWgw8HXhx)9IYiy*:JZjz m !1AQa"q2#BRbr3$4CS%cs5DT
&6E'dtU7()euFVfvGWgw8HXhx9IYiy*:JZjz ? v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb'%F<IP2 4ꧧfˌԡrRI7/AdKKAo&/>P ?! 3dM6e{y9ҌUIT-sO82qwF{K$n['b]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*Uy8\ɳ p\ x|(k2 I ^uƮO}ñWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*Ƽ
S`?r.we c~>}~^M \:a?WO oW'K>|aثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWbFxu2#:=E|h8K1>i._οxƏx:=E|h8K1>k]~^E|hxK1>h,o3#:)cep WjDv?ݘc~>}ُ6@=:aH'R?{\/3= w"u>4{xK1>i._οxƏx:=%X5._οxƏx:=E|h}b/_cG|]~G ^rR1 wUثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*UثWb]v*}'˰yRVAǏV> vwb_2Kͪ8% o ? :1OIʷ :1R} }?' *O O ??O_Iʷ Cc Ο~Tpw}?? }?' *O O ??O_Iʷ :1R} }?' *O O ??O_I+ˍ