%PDF-1.3
%
1 0 obj
<<
/FormType 1
/Subtype /Form
/Resources
<<
/Font
<<
/F3 2 0 R
/F2 3 0 R
/F1 4 0 R
>>
/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]
/XObject
<<
/XT4 5 0 R
>>
>>
/Type /XObject
/BBox [0 0 595.28 841.89]
/Filter /FlateDecode
/Length 434
/Matrix [1 0 0 1 0 0]
>>
stream
xTMo0Wc{oKuRt@C)JmwFd;^%+ADz2%*QЀ&?Ɨzu|ʑ's|zjd
Vv?&YoVIzK\6>'fc 2I4dmT(8Xĺ^+bJeoSLZl2Ƥs_b1-.˅X2\"M!.WU7J4%R&BF̞?"9\U]#!
l8X
t7N83&ϵ?Ox8kUnNBx8߁u$#Q21^c7BvRKݱwCJ&zJH)h#V0z}aH~7{LD=S
endstream
endobj
2 0 obj
<<
/Encoding /WinAnsiEncoding
/Subtype /Type1
/Name /F3
/Type /Font
/BaseFont /Helvetica-Oblique
>>
endobj
3 0 obj
<<
/Encoding /WinAnsiEncoding
/Subtype /Type1
/Name /F2
/Type /Font
/BaseFont /Helvetica-Bold
>>
endobj
4 0 obj
<<
/Encoding /WinAnsiEncoding
/Subtype /Type1
/Name /F1
/Type /Font
/BaseFont /Helvetica
>>
endobj
5 0 obj
<<
/FormType 1
/Subtype /Form
/Resources
<<
/Font
<<
/F2 3 0 R
/F1 4 0 R
>>
/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]
>>
/Type /XObject
/BBox [0.000000 0.000000 595.276000 841.890000]
/Filter /FlateDecode
/Length 118
/Matrix [1 0 0 1 0 0]
>>
stream
x
0D~ōԢ5MDMT'G#H-[CzЫ6YթVcH:/;+4XÎ;57\Z2cLN>
+
endstream
endobj
6 0 obj
<<
/Filter /FlateDecode
/Length 10
>>
stream
x+ |
endstream
endobj
7 0 obj
<<
/Filter /FlateDecode
/Length 47
>>
stream
xS**T0г4107Q0 A(IUЏ44RpW
endstream
endobj
8 0 obj
<<
/Filter /FlateDecode
/Length 10
>>
stream
x+ |
endstream
endobj
9 0 obj
<<
/Filter /FlateDecode
/Length 47
>>
stream
xS**T0г4107Q0 A(IUЏ44VpW
%
endstream
endobj
10 0 obj
<<
/Filter /FlateDecode
/Length 10
>>
stream
x+ |
endstream
endobj
11 0 obj
<<
/Filter /FlateDecode
/Length 46
>>
stream
xS**T0г4107Q0 A(IUЏȴPpW
|
endstream
endobj
12 0 obj
<<
/Filter /FlateDecode
/Length 10
>>
stream
x+ |
endstream
endobj
13 0 obj
<<
/Filter /FlateDecode
/Length 46
>>
stream
xS**T0г4107Q0 A(IUЏ4VpW
O
endstream
endobj
14 0 obj
<<
/Filter /FlateDecode
/Length 10
>>
stream
x+ |
endstream
endobj
15 0 obj
<<
/Filter /FlateDecode
/Length 47
>>
stream
xS**T0г4107Q0 A(IUЏ44PpW
endstream
endobj
16 0 obj
<<
/Filter /FlateDecode
/Length 10
>>
stream
x+ |
endstream
endobj
17 0 obj
<<
/Filter /FlateDecode
/Length 46
>>
stream
xS**T0г4107Q0 A(IUЏ4UpW
a
endstream
endobj
18 0 obj
<<
/Filter /FlateDecode
/Length 10
>>
stream
x+ |
endstream
endobj
19 0 obj
<<
/Filter /FlateDecode
/Length 46
>>
stream
xS**T0г4107Q0 A(IUЏ4TpW
=
endstream
endobj
20 0 obj
<<
/Filter /FlateDecode
/Length 10
>>
stream
x+ |
endstream
endobj
21 0 obj
<<
/Filter /FlateDecode
/Length 46
>>
stream
xS**T0г4107Q0 A(IUЏ4RpW
F
endstream
endobj
22 0 obj
<<
/Filter /FlateDecode
/Length 10
>>
stream
x+ |
endstream
endobj
23 0 obj
<<
/Filter /FlateDecode
/Length 46
>>
stream
xS**T0г4107Q0 A(IUЏ4WpW
s
endstream
endobj
24 0 obj
<<
/Filter /FlateDecode
/Length 10
>>
stream
x+ |
endstream
endobj
25 0 obj
<<
/Filter /FlateDecode
/Length 47
>>
stream
xS**T0г4107Q0 A(IUЏ44TpW
endstream
endobj
26 0 obj
<<
/Filter /FlateDecode
/Length 10
>>
stream
x+ |
endstream
endobj
27 0 obj
<<
/Filter /FlateDecode
/Length 47
>>
stream
xS**T0г4107Q0 A(IUЏ44QpW
.
endstream
endobj
28 0 obj
<<
/Filter /FlateDecode
/Length 10
>>
stream
x+ |
endstream
endobj
29 0 obj
<<
/Filter /FlateDecode
/Length 46
>>
stream
xS**T0г4107Q0 A(IUЏ4SpW
j
endstream
endobj
30 0 obj
<<
/Filter /FlateDecode
/Length 10
>>
stream
x+ |
endstream
endobj
31 0 obj
<<
/Filter /FlateDecode
/Length 46
>>
stream
xS**T0г4107Q0 A(IUЏ4PpW
4
endstream
endobj
32 0 obj
<<
/Filter /FlateDecode
/Length 10
>>
stream
x+ |
endstream
endobj
33 0 obj
<<
/Filter /FlateDecode
/Length 46
>>
stream
xS**T0г4107Q0 A(IUЏ4QpW
X
endstream
endobj
34 0 obj
<<
/Filter /FlateDecode
/Length 10
>>
stream
x+ |
endstream
endobj
35 0 obj
<<
/Filter /FlateDecode
/Length 46
>>
stream
xS**T0г4107Q0 A(IUЏȴTpW
endstream
endobj
36 0 obj
<<
/D [37 0 R /XYZ 322 320 null]
>>
endobj
38 0 obj
<<
/D [39 0 R /XYZ 313 188 null]
>>
endobj
40 0 obj
<<
/Border [0 0 0]
/Subtype /Link
/Type /Annot
/Rect [70.979 754.299 111.968 762.293]
/A
<<
/URI (http://www.dovepress.com)
/S /URI
>>
>>
endobj
41 0 obj
<<
/Border [0 0 0]
/Subtype /Link
/Type /Annot
/Rect [454.11 317.31 470.098 325.304]
/Dest ( r e f C I T 0 0 2 9)
>>
endobj
42 0 obj
<<
/Border [0 0 0]
/Subtype /Link
/Type /Annot
/Rect [243.893 646.639 251.206 656.617]
/Dest ( C I T 0 0 3 9)
>>
endobj
43 0 obj
<<
/Annots [44 0 R 45 0 R 46 0 R 47 0 R 48 0 R 49 0 R 50 0 R 51 0 R 52 0 R 53 0 R 54 0 R 55 0 R 56 0 R 57 0 R 58 0 R 59 0 R 60 0 R 61 0 R 62 0 R 63 0 R]
/Resources
<<
/Font
<<
/T1_2 64 0 R
/T1_1 65 0 R
/T1_0 66 0 R
/T1_6 67 0 R
/T1_5 68 0 R
/T1_4 69 0 R
/T1_3 70 0 R
>>
/ProcSet [/PDF /Text /ImageB /ImageC /ImageI]
/XObject
<<
/Xi1 1 0 R
>>
/ExtGState
<<
/GS1 71 0 R
>>
/ColorSpace
<<
/CS1 72 0 R
>>
>>
/Rotate 0
/Type /Page
/Contents [18 0 R 73 0 R 19 0 R]
/Parent 74 0 R
/MediaBox [0 0 612 792]
/CropBox [0 0 612 792]
>>
endobj
75 0 obj
<<
/D [37 0 R /XYZ 322 280 null]
>>
endobj
76 0 obj
<<
/D [39 0 R /XYZ 374 188 null]
>>
endobj
77 0 obj
<<
/Border [0 0 0]
/Subtype /Link
/Type /Annot
/Rect [491.868 25.115 522.538 31.124]
/A
<<
/URI (http://www.dovepress.com)
/S /URI
>>
>>
endobj
78 0 obj
<<
/Border [0 0 0]
/Subtype /Link
/Type /Annot
/Rect [532.46 287.32 548.447 295.313]
/Dest ( r e f C I T 0 0 3 0)
>>
endobj
79 0 obj
<<
/Border [0 0 0]
/Subtype /Link
/Type /Annot
/Rect [253.02 646.639 260.277 656.617]
/Dest ( C I T 0 0 4 0)
>>
endobj
44 0 obj
<<
/Border [0 0 0]
/Subtype /Link
/Type /Annot
/Rect [264.529 718.923 268.271 728.957]
/Dest ( C I T 0 0 0 5)
>>
endobj
80 0 obj [/Indexed 72 0 R 180 81 0 R]
endobj
82 0 obj
<<
/D [37 0 R /XYZ 322 250 null]
>>
endobj
83 0 obj
<<
/D [39 0 R /XYZ 410 506 null]
>>
endobj
84 0 obj
<<
/Border [0 0 0]
/Subtype /Link
/Type /Annot
/Rect [399.572 277.285 497.027 285.279]
/A
<<
/URI (https://doi.org/10.1371/journal.pone.0167433)
/S /URI
>>
>>
endobj
85 0 obj
<<
/Border [0 0 0]
/Subtype /Link
/Type /Annot
/Rect [101.991 577.644 109.247 587.679]
/Dest ( C I T 0 0 4 1)
>>
endobj
45 0 obj
<<
/Border [0 0 0]
/Subtype /Link
/Type /Annot
/Rect [270.198 718.923 273.94 728.957]
/Dest ( C I T 0 0 0 6)
>>
endobj
86 0 obj
<<
/Metadata 87 0 R
/Subtype /Image
/Type /XObject
/Width 42
/Filter /FlateDecode
/Height 42
/BitsPerComponent 8
/Length 484
/ColorSpace 80 0 R
>>
stream
hb`ddb&XXXY NN..n_@ f`!-*&&
Y9yJqE%ee PUSǧRC]SK[GGe40426155s^|*-mlJQQG'g&JW7<*=<}ʀ &P >hmTttST)TUg TJ$1L♙PKe@VvvNN.Pe^~~6PYXT\RRZZTY^QQRRRYC}uMmm]]=PeCccmmSsm]@L=}8TOe@'Mơri(*sP9qYQQtu͚5w|*,\h%@K-[h8TRT\
TQQq89aUI/JZ[鍡\zcA&JY~PMPjl5f[ \ ͥ
endstream
endobj
88 0 obj
<<
/D [37 0 R /XYZ 322 218 null]
>>
endobj
89 0 obj
<<
/D [90 0 R /XYZ 233 188 null]
>>
endobj
91 0 obj
<<
/Subtype /Type1C
/Filter /FlateDecode
/Length 516
>>
stream
hlo` [҃ѨVƛAt.q YxbPǠR2- _ېLMof'{Y=(rم(\
..
D6WcOll;[7Թ\p;:בK(=_Χ/~<Lq(dL&3)H$\^fhMAe55C\hlf8n&B1·avM9&nq"Q̖@R7
B¦&lKLʬK$I$)4jubu :q0ytp=??g?5:RЄ-w?G=w|b'VT_".;HbE)
"U5eBҴp]e42y>ͧss::F
?
rC*hΦ47N&+8'nhvo{ۑHALoR6Q4Q+5
?
endstream
endobj
92 0 obj
<<
/Border [0 0 0]
/Subtype /Link
/Type /Annot
/Rect [334.431 247.294 349.455 255.288]
/Dest ( r e f C I T 0 0 3 1)
>>
endobj
93 0 obj
<<
/Border [0 0 0]
/Subtype /Link
/Type /Annot
/Rect [210.614 535.691 217.927 545.669]
/Dest ( C I T 0 0 4 1)
>>
endobj
46 0 obj
<<
/Border [0 0 0]
/Subtype /Link
/Type /Annot
/Rect [146.891 592.951 150.69 602.929]
/Dest ( C I T 0 0 0 5)
>>
endobj
87 0 obj
<<
/Subtype /XML
/Type /Metadata
/Length 19075
>>
stream
2018-09-13T16:15:28+05:30
2019-02-05T19:16:05+05:30
2019-02-05T19:16:05+05:30
Adobe Photoshop CS6 (Windows)
xmp.iid:CF9A27F54329E911A27AE9761ED54AA3
xmp.did:302F178C3DD2E51190F4805D0BABA7DE
xmp.did:433774B5DFB7E8118FC097DBF38A2E6F
proof:pdf
xmp.iid:433774B5DFB7E8118FC097DBF38A2E6F
xmp.did:433774B5DFB7E8118FC097DBF38A2E6F
xmp.did:302F178C3DD2E51190F4805D0BABA7DE
proof:pdf
converted
from application/x-indesign to application/pdf
Adobe InDesign CS6 (Windows)
/
2018-08-17T09:46:40+05:30
saved
xmp.iid:3FCB61AF3EB7E811B2DB92E79AA0BAD2
2018-09-13T16:14:52+05:30
Adobe Illustrator CS6 (Windows)
/
saved
xmp.iid:40CB61AF3EB7E811B2DB92E79AA0BAD2
2018-09-13T16:15:29+05:30
Adobe Illustrator CS6 (Windows)
/
converted
from application/postscript to application/vnd.adobe.photoshop
saved
xmp.iid:433774B5DFB7E8118FC097DBF38A2E6F
2018-09-14T11:40:31+05:30
Adobe Photoshop CS6 (Windows)
/
converted
from application/postscript to image/epsf
derived
converted from application/vnd.adobe.photoshop to image/epsf
saved
xmp.iid:443774B5DFB7E8118FC097DBF38A2E6F
2018-09-14T11:40:31+05:30
Adobe Photoshop CS6 (Windows)
/
saved
xmp.iid:CF9A27F54329E911A27AE9761ED54AA3
2019-02-05T19:16:05+05:30
Adobe Photoshop CS6 (Windows)
/
image/epsf
Adobe PDF Library 10.0.1
False
215.900000
279.400000
Millimeters
1
False
False
Cyan
Magenta
Yellow
Black
Default Swatch Group
0
4
U.S. Web Coated (SWOP) v2
endstream
endobj
94 0 obj
<<
/D [37 0 R /XYZ 322 187 null]
>>
endobj
95 0 obj
<<
/D [90 0 R /XYZ 480 738 null]
>>
endobj
96 0 obj
<<
/StemV 0
/ItalicAngle 0
/Type /FontDescriptor
/FontName /DJMFJE+AdvOTf90d833a.I+fb
/Ascent 0
/Flags 4
/FontBBox [-188 -218 644 745]
/FontFile3 91 0 R
/CapHeight 0
/Descent 0
/CharSet (/uniFB01)
>>
endobj
97 0 obj
<<
/Border [0 0 0]
/Subtype /Link
/Type /Annot
/Rect [334.431 217.304 350.419 225.298]
/Dest ( r e f C I T 0 0 3 2)
>>
endobj
98 0 obj
<<
/Border [0 0 0]
/Subtype /Link
/Type /Annot
/Rect [273.827 451.672 281.31 461.65]
/Dest ( C I T 0 0 4 1)
>>
endobj
47 0 obj
<<
/Border [0 0 0]
/Subtype /Link
/Type /Annot
/Rect [154.431 592.951 158.173 602.929]
/Dest ( C I T 0 0 0 7)
>>
endobj
99 0 obj
<<
/D [37 0 R /XYZ 322 146 null]
>>
endobj
100 0 obj
<<
/D [90 0 R /XYZ 489 738 null]
>>
endobj
101 0 obj
<<
/Filter /FlateDecode
/Length 214
>>
stream
hTP0A7\u8RtCHW'rӡI(l~zϖvߒ
tzKqr3kX.g=*2e
8;k!p
P
6nG 4
})T#̼x**N^idEB]#!ٓq]xl>cqwE+rgh._-$qKzw>i "h
endstream
endobj
102 0 obj
<<
/Border [0 0 0]
/Subtype /Link
/Type /Annot
/Rect [418.28 217.304 495.666 225.298]
/A
<<
/URI (https://doi.org/10.1136/pgmj.56.652.85)
/S /URI
>>
>>
endobj
103 0 obj
<<
/Border [0 0 0]
/Subtype /Link
/Type /Annot
/Rect [283.181 451.672 290.721 461.65]
/Dest ( C I T 0 0 4 2)
>>
endobj
48 0 obj
<<
/Border [0 0 0]
/Subtype /Link
/Type /Annot
/Rect [107.036 494.929 110.778 504.907]
/Dest ( C I T 0 0 0 8)
>>
endobj
104 0 obj [/Indexed 72 0 R 167 105 0 R]
endobj
106 0 obj
<<
/D [107 0 R /XYZ 54 742 null]
>>
endobj
108 0 obj
<<
/D [107 0 R /XYZ 54 342 null]
>>
endobj
109 0 obj
<<
/Subtype /Type1C
/Filter /FlateDecode
/Length 4425
>>
stream
hބW}}v(=僚BBH!B(q|>|:Nj/8iw_ZI+NcC . 4Τ3d2Mghgut6$t4{mWtuww{z{vۿz莻nm>}w=W+_^ٮ+|pymr;MɁ&}SG|7x`llǓ#CӁOBoc>}eu}W]];f_ ]^r}[K=˞D'~ro}F{U7]W?{gz
;;ιx5^aꈒVRIfӨȥxO\GIZV| )*y\!Jx)ƑzlzEcyWpkygI
% ]7tLJY{oa]uR%F.VJ\dof6<-3Nwnyn' 7qzp^xCAP8~ 8jq\+co쟄P;Q;i'Ok_+gWoFOOᬥTSpokϻZ͝P41e:Z#\Үyed9]CZ߂9> :
aiBYpB]b3NF8ˤUKU ?r{zgΏSAɿ[@{^4*m
qu?!Yu
SэPm0G##>Q$f3Ʉ/n+
i+
:/z~mit
kd9df0D{n[z(Tx)`-'ћ77]n8)&hNÄGunmu_ ei cSQˢL"%qlq[
T6-j_hO?9'(Qp!xH?6/G~>`'_=y9z7Fܷ!O&k NF($B!<'R`8[)0&cfCףnTllE$L8n_
fTpyiU?$KӁ8! d"lFi;a2`&
T.`1l\b4}adԁ^F./qedZkR