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Influenza virus strains with a fusion threshold of pH5.5 or lower are inhibited by amantadine

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Summary

Nineteen influenza virus strains were examined for susceptibility to amantadine-HCl (AMT) and for pH-thresholds of haemagglutinin-induced haemolysis. Whereas pH-thresholds below 5.5 were not seen in AMT-resistant strains, AMT-sensitive strains showed pH-thresholds either below or above 5.5.

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Authors and Affiliations

  1. Department of Virology and WHO Influenza Centre, Erasmus University, Rotterdam, The Netherlands

    W. E. P. Beyer, H. van Driel & N. Masurel

  2. National Institute for Medical Research, London, UK

    R. W. H. Ruigrok

Authors
  1. W. E. P. Beyer
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  2. R. W. H. Ruigrok
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  3. H. van Driel
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  4. N. Masurel
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Beyer, W.E.P., Ruigrok, R.W.H., van Driel, H. et al. Influenza virus strains with a fusion threshold of pH5.5 or lower are inhibited by amantadine. Archives of Virology 90, 173–181 (1986). https://doi.org/10.1007/BF01314156

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  • DOI: https://doi.org/10.1007/BF01314156

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