This is a preview of subscription content, access via your institution
Relevant articles
Open Access articles citing this article.
-
TET proteins and the control of cytosine demethylation in cancer
Genome Medicine Open Access 29 January 2015
Access options
Subscribe to this journal
Receive 12 print issues and online access
$259.00 per year
only $21.58 per issue
Buy this article
- Purchase on Springer Link
- Instant access to full article PDF
Prices may be subject to local taxes which are calculated during checkout
References
Langemeijer SM, Kuiper RP, Berends M, Knops R, Aslanyan MG, Massop M et al. Acquired mutations in TET2 are common in myelodysplastic syndromes. Nat Genet 2009; 41: 838–842.
Delhommeau F, Dupont S, Della Valle V, James C, Trannoy S, Masse A et al. Mutation in TET2 in myeloid cancers. N Engl J Med 2009; 360: 2289–2301.
Tefferi A, Pardanani A, Lim KH, bdel-Wahab O, Lasho TL, Patel J et al. TET2 mutations and their clinical correlates in polycythemia vera, essential thrombocythemia and myelofibrosis. Leukemia 2009; 23: 905–911.
Jankowska AM, Szpurka H, Tiu RV, Makishima H, Afable M, Huh J et al. Loss of heterozygosity 4q24 and TET2 mutations associated with myelodysplastic/myeloproliferative neoplasms. Blood 2009; 113: 6403–6410.
Abdel-Wahab O, Mullally A, Hedvat C, Garcia-Manero G, Patel J, Wadleigh M et al. Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies. Blood 2009; 114: 144–147.
Mullighan CG, Goorha S, Radtke I, Miller CB, Coustan-Smith E, Dalton JD et al. Genome-wide analysis of genetic alterations in acute lymphoblastic leukaemia. Nature 2007; 446: 758–764.
Kuiper RP, Schoenmakers EF, van Reijmersdal SV, Hehir-Kwa JY, Geurts van Kessel A, Geurts van Kessel FN et al. High-resolution genomic profiling of childhood ALL reveals novel recurrent genetic lesions affecting pathways involved in lymphocyte differentiation and cell cycle progression. Leukemia 2007; 21: 1258–1266.
Tahiliani M, Koh KP, Shen Y, Pastor WA, Bandukwala H, Brudno Y et al. Conversion of 5-methylcytosine to 5-hydroxymethylcytosine in mammalian DNA by MLL partner TET1. Science 2009; 324: 930–935.
Ito S, D’Alessio AC, Taranova OV, Hong K, Sowers LC, Zhang Y . Role of Tet proteins in 5mC to 5hmC conversion, ES-cell self-renewal and inner cell mass specification. Nature 2010; 466: 1129–1133.
Acknowledgements
This work was supported by grants from ZonMW (to SMCL) and the Dutch Cancer Society (to RPK and AG and PMH).
Author information
Authors and Affiliations
Corresponding author
Ethics declarations
Competing interests
The authors declare no conflict of interest.
Additional information
Supplementary Information accompanies the paper on the Leukemia website
Supplementary information
Rights and permissions
About this article
Cite this article
Langemeijer, S., Jansen, J., Hooijer, J. et al. TET2 mutations in childhood leukemia. Leukemia 25, 189–192 (2011). https://doi.org/10.1038/leu.2010.243
Published:
Issue Date:
DOI: https://doi.org/10.1038/leu.2010.243
This article is cited by
-
Do hematopoietic stem cells get old?
Leukemia (2017)
-
B-acute lymphoblastic leukemia/lymphoma (B-ALL) with precedent or concurrent myelodysplastic syndrome (MDS) with deletion 5q
Journal of Hematopathology (2017)
-
EZH2 mutations and promoter hypermethylation in childhood acute lymphoblastic leukemia
Journal of Cancer Research and Clinical Oncology (2016)
-
TET proteins and the control of cytosine demethylation in cancer
Genome Medicine (2015)
-
The Ten-Eleven Translocation-2 (TET2) gene in hematopoiesis and hematopoietic diseases
Leukemia (2014)