Abstract

Percutaneous coronary intervention (PCI) has brought a major revolution in the way we manage coronary artery disease. Since the first intervention by Andreas Grüntzig in 1977, development of the technology has been relentless and today PCI has been established as one of the major pillars of treatment of coronary heart disease alongside its medical and surgical solutions. Stent implantation during PCI has given the needed edge to PCI, not only in restoring coronary flow but moreover in maintaining it. The aim of this thesis were to : 1. Determine the long term outcome of drug eluting stent implantation compared to bare metal stents in the general PCI population and explore clinical benefits of newer generation drug eluting stents. 2. Examine the clinical outcome of drug eluting stents in patient populations prone to aggressive coronary artery disease. 3. Analyse determinants and prognostic value of myocardial no reflow after stenting in acute myocardial infarction. 4. Utilize OCT to gain further insights into intra coronary thrombus and the effects for stenting and thrombectomy in patients with STEMI. 5. Establish the usefulness of the Syntax score in risk stratification of patients presenting with ST elevation myocardial infarction. 6. Assess the outcome of drug-eluting stent implantation in bypass grafts and evaluate a dedicated stent developed for bifurcation stenting including that of the left main stem.

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P.W.J.C. Serruys (Patrick) , R.J.M. van Geuns (Robert Jan)
Erasmus University Rotterdam
Financial Support for printing of the thesis by St Jude Medical Biosensors Biotronik
hdl.handle.net/1765/77383
Erasmus MC: University Medical Center Rotterdam

Magro, M. (2015, January 20). Percutaneous Coronary Interventions in Stable and Acute Coronary Syndromes: Stent technology, lesion complexity and clinical outcome. Retrieved from http://hdl.handle.net/1765/77383