Elsevier

Lung Cancer

Volume 71, Issue 3, March 2011, Pages 247-248
Lung Cancer

Editorial
Lung cancer screening: What is the benefit and what do we do about it?

https://doi.org/10.1016/j.lungcan.2010.12.010Get rights and content

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Conflicts of interest

Both authors report no conflicts of interest in regard to employment, consultancies, stock ownership, honoraria, paid expert testimony, patent applications/registrations and grants and any other funding.

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    The trial was terminated when a 20.3% reduction was demonstrated because it would be unethical to proceed with the trial if a mortality reduction of such magnitude was statistically demonstrated in the LDCT arm. The proven effectiveness of LDCT would support offering LDCT to the control arm and to the general population (25). Second, because LDCT screening has high sensitivity but low specificity, the positive predictive value of a positive study is very low (5.2%), whereas the negative predictive value (NPV) is very high (99.9%).

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