2008-12-01
Human herpesvirus type 6 reactivation after haematopoietic stem cell transplantation
Publication
Publication
Journal of Clinical Virology , Volume 43 - Issue 4 p. 361- 366
Human herpesvirus type 6 (HHV6) is known to reactivate after hematopoetic stem cell transplantation (HSCT) and has been suggested to be associated with increased mortality and severe clinical manifestations, including graft versus host disease (GvHD). The exact etiological role of HHV6 reactivation in increased morbidity and mortality after HSCT remains unclear. This review will focus on the current available evidence of HHV6 reactivation after HSCT and its immuno-modulatory capacities, with particular emphasis on the severe complication GvHD. At present, no effective specific antiviral treatment for HHV6 reactivation has been identified. The currently available antiviral agents are outlined, as well as possible future strategies for the treatment of HHV6 reactivation. Non-toxic, specific treatment or prevention of HHV6 reactivation might improve the safety and efficacy of the HSCT procedure.
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doi.org/10.1016/j.jcv.2008.08.008, hdl.handle.net/1765/30238 | |
Journal of Clinical Virology | |
Organisation | Erasmus MC: University Medical Center Rotterdam |
de Pagter, P. J., Schuurman, R., Meijer, E., van Baarle, D., Sanders, E., & Boelens, J. (2008). Human herpesvirus type 6 reactivation after haematopoietic stem cell transplantation. Journal of Clinical Virology, 43(4), 361–366. doi:10.1016/j.jcv.2008.08.008 |