Context: A biomarker for discriminating mechanisms of chemotherapy-induced thrombocytopenia (CIT) (i.e. increased platelet destruction and decreased platelet production) would be valuable in managing treatment. Objective: We explored the discriminating value of platelet size indices for this purpose in a population of adult oncology patients. Materials and methods: Mean platelet volume (MPV) and platelet distribution width (PDW) were compared between patients with (i) thrombocytopenia possibly due to increased platelet destruction; (ii) thrombocytopenia possibly due to decreased platelet destruction; and (iii) no thrombocytopenia. Results and conclusions: We obtained negative results, suggesting that these indices are not useful for discriminating different CIT mechanisms.

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Keywords Biomarker, mean platelet volume, platelet distribution width
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Journal Biomarkers
ten Berg, M.J, Huisman, A.M, van den Bemt, P.M.L.A, den Breeijen, J.H, Egberts, T.C.G, & van Solinge, W.W. (2011). Discriminative value of platelet size indices for the identification of the mechanism of chemotherapy-induced thrombocytopenia. Biomarkers, 16(1), 51–57. doi:10.3109/1354750X.2010.526243