PaperConstruction and evaluation of an expression vector allowing the stable expression of foreign antigens in a Salmonella typhimurium vaccine strain
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Cited by (21)
Antigen delivery systems ii. development of live recombinant attenuated bacterial antigen and dna vaccine delivery vector vaccines
2005, Mucosal Immunology, Two-Volume SetUse of the α-hemolysin secretion system of Escherichia coli for antigen delivery in the Salmonella typhi Ty21a vaccine strain
2004, International Journal of Medical MicrobiologyCitation Excerpt :This can be achieved either by direct expression of heterologous protein antigens by the bacteria or by the delivery of eukaryotic antigen expression vectors by the carrier organisms into professional antigen presenting cells of the vaccinated host (Hormaeche and Khan, 1996; Lindberg, 1998; Mollenkopf et al., 2001; Dietrich et al., 2003a). In order to achieve stable expression of heterologous antigens in attenuated LBV, several different strategies were developed (Tijhaar et al., 1994; Gentschev et al., 1996; Russmann et al., 1998; Xu et al., 1998; Roberts et al., 1998; Paterson, 2003). One of the most promising approaches in this direction is the use of the E. coli α-hemolysin (HlyA) secretion system for antigen delivery (Gentschev et al., 2002).
Salmonella vaccines for use in humans: Present and future perspectives
2002, FEMS Microbiology ReviewsCitation Excerpt :Under some circumstances, however, high-level expression of a heterologous antigen has been found to be toxic to the Salmonella carrier. One possible solution is to construct expression cassettes in which promoters are located on inverting sequences, ensuring that heterologous antigen expression only occurs when the promoters are in frame with the antigen-encoding sequences [86–88]. An alternative strategy involves the use of promoters that allow expression of heterologous antigens at particular cellular sites, so-called in vivo-inducible promoters.
Salmonella: Immune responses and vaccines
2001, Veterinary JournalDelivery of protein antigens and DNA by attenuated intracellular bacteria
2001, International Journal of Medical Microbiology
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Present address: Department of Pathology, Free University Hospital, de Boelelaan 1117, 1081 HV Amsterdam, The Netherlands.