Elsevier

Vaccine

Volume 13, Issue 8, 1995, Pages 703-705
Vaccine

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Cytotoxic T lymphocyte memory: role in cross-protective immunity against influenza?

https://doi.org/10.1016/0264-410X(94)00030-QGet rights and content

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  • Cited by (34)

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      It was suggested that also functional constraints may limit influenza viruses to escape efficiently from recognition by CTL specific for highly conserved epitopes (Berkhoff et al., 2005, 2006). The immune response induced by influenza A virus infection can to a certain extent provide protection against subsequent infections with an influenza A virus of another subtype (Grebe et al., 2008; Rimmelzwaan and Osterhaus, 1995). This so-called heterosubtypic immunity depends on the cross-reactivity of antibodies and especially T cells.

    • Influenza virus-specific cytotoxic T lymphocytes: a correlate of protection and a basis for vaccine development

      2007, Current Opinion in Biotechnology
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      Other evidence in support of a protective role of CTL was obtained by vaccination aiming at the induction of CTL responses to the conserved internal viral proteins. Protective CTL responses were achieved especially by vaccination with plasmid DNA from which the NP gene was expressed [24•,25–27], but also by vaccination with NP subunit preparations [28–31], while the use of recombinant vaccinia viruses expressing the influenza virus NP gene was relatively inefficient [32]. The evidence for a protective role for CTL in humans is sparse and in most cases circumstantial.

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