Summary:
Respiratory viruses are increasingly recognized as a cause of pneumonitis following haematopoietic stem cell transplantation (HSCT). However, frequently, no pathogen is identified in cases of suspected viral pneumonia. Recently, a previously undescribed paramyxovirus, designated ‘human metapneumovirus’ (hMPV), was isolated from children with respiratory illness. We have detected hMPV as the sole pathogen in the nasopharyngeal aspirate of an HSCT recipient who succumbed to progressive respiratory failure following an upper respiratory prodrome. This report highlights the importance of further studies to elucidate the role of hMPV in causing respiratory illnesses in the HSCT population.
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References
Bowden RA . Respiratory virus infections after marrow transplant: the Fred Hutchinson Cancer Research Center experience. Am J Med 1997; 102: 27–30.
Chakrabarti S, Collingham K, Marshall T et al. Respiratory viral infections in adult T cell depleted stem cell transplants: the role of cellular immunity. Transplantation 2001; 72: 1460–1463.
Whimbey E, Champlin RE, Couch R et al. Community respiratory virus infections among hospitalized adult bone marrow transplant recipients. Clin Infect Dis 1996; 22: 778–782.
Van den Hoogen BG, Bestebroer TM, Osterhaus ADME, Fouchier RAM . Analysis of the genomic sequence of a human metapneumovirus. Virology 2002; 295: 119–132.
Van den Hoogen BG, de Jong JC, Groen J, Kuiken T, de Groot R, Fouchier RAM, Osterhaus ADME . A newly discovered human pneumovirus isolated from young children with respiratory tract disease. Nature Med 2001; 7: 719–724.
Peret TCT, Boivin G, Li Y, Couillard M, Humphrey C, Osterhaus ADME, Erdman D, Anderson LJ . Characterization of human metapneumoviruses isolated from patients in North America. J Infect Dis 2002; 185: 1660–1663.
Pelletier G, Dery P, Abed Y, Boivin G . Respiratory tract reinfections by the new human metapneumovirus in an immunocompromised child. Emerg Infect Dis 2002; 8: 976–978.
Acknowledgements
We thank the staff of the Public Health Laboratory at Heartlands Hospital, Birmingham, UK, for undertaking the microbiological investigations.
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Cane, P., van den Hoogen, B., Chakrabarti, S. et al. Human metapneumovirus in a haematopoietic stem cell transplant recipient with fatal lower respiratory tract disease. Bone Marrow Transplant 31, 309–310 (2003). https://doi.org/10.1038/sj.bmt.1703849
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DOI: https://doi.org/10.1038/sj.bmt.1703849
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