%PDF-1.4
%
1 0 obj
<<
/PageLabels 2 0 R
/OpenAction [3 0 R /XYZ 0 841.9000244141 0]
/Names 4 0 R
/Type /Catalog
/Metadata 5 0 R
/PageMode /UseNone
/Pages 6 0 R
>>
endobj
7 0 obj
<<
/Creator (Unknown)
/Producer <58455020342E39206275696C642032303037303331323B206D6F646966696564207573696E6720695465787420352E302E332028632920315433585420425642413B206D6F646966696564207573696E67206954657874AE20352E312E3320A9323030302D323031312031543358542042564241>
/Title (Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data)
/Trapped /False
/ModDate (D:20140710151150+01'00')
/Author <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>
/CreationDate (D:20140710151143)
/CrossmarkMajorVersionDate (2014-07-10)
/CrossMarkDomains#5B1#5D (bmj.com)
/doi (10.1136/bmj.g4164)
/CrossmarkDomainExclusive (false)
>>
endobj
2 0 obj
<<
/Nums [0 8 0 R]
>>
endobj
3 0 obj
<<
/CropBox [0 0 595.2760009766 841.8900146484]
/Parent 9 0 R
/Type /Page
/Contents [10 0 R 11 0 R 12 0 R 13 0 R]
/Resources 14 0 R
/MediaBox [0 0 595.2760009766 841.8900146484]
/TrimBox [0 0 595.2760009766 841.8900146484]
/BleedBox [0 0 595.2760009766 841.8900146484]
/Annots [15 0 R 16 0 R 17 0 R 18 0 R]
>>
endobj
4 0 obj
<<
/Dests 19 0 R
>>
endobj
5 0 obj
<<
/Type /Metadata
/Subtype /XML
/Length 20 0 R
>>
stream
Michael V Holmes, Caroline E Dale, Luisa Zuccolo, Richard J Silverwood, Yiran Guo, Zheng Ye, David Prieto-Merino, Abbas Dehghan, Stella Trompet, Andrew Wong, Alana Cavadino, Dagmar Drogan, Sandosh Padmanabhan, Shanshan Li, Ajay Yesupriya, Maarten Leusink, Johan Sundstrom, Jaroslav A Hubacek, Hynek Pikhart, Daniel I Swerdlow, Andrie G Panayiotou, Svetlana A Borinskaya, Chris Finan, Sonia Shah, Karoline B Kuchenbaecker, Tina Shah, Jorgen Engmann, Lasse Folkersen, Per Eriksson, Fulvio Ricceri, Olle Melander, Carlotta Sacerdote, Dale M Gamble, Sruti Rayaprolu, Owen A Ross, Stela McLachlan, Olga Vikhireva, Ivonne Sluijs, Robert A Scott, Vera Adamkova, Leon Flicker, Frank M van Bockxmeer, Christine Power, Pedro Marques-Vidal, Tom Meade, Michael G Marmot, Jose M Ferro, Sofia Paulos-Pinheiro, Steve E Humphries, Philippa J Talmud, Irene Mateo Leach, Niek Verweij, Allan Linneberg, Tea Skaaby, Pieter A Doevendans, Maarten J Cramer, Pim van der Harst, Olaf H Klungel, Nicole F Dowling, Anna F Dominiczak, Meena Kumari, Andrew N Nicolaides, Cornelia Weikert, Heiner Boeing, Shah Ebrahim, Tom R Gaunt, Jackie F Price, Lars Lannfelt, Anne Peasey, Ruzena Kubinova, Andrzej Pajak, Sofia Malyutina, Mikhail I Voevoda, Abdonas Tamosiunas, Anke H Maitland-van der Zee, Paul E Norman, Graeme J Hankey, Manuela M Bergmann, Albert Hofman, Oscar H Franco, Jackie Cooper, Jutta Palmen, Wilko Spiering, Pim A de Jong, Diana Kuh, Rebecca Hardy, Andre G Uitterlinden, M Arfan Ikram, Ian Ford, Elina Hyppönen, Osvaldo P Almeida, Nicholas J Wareham, Kay-Tee Khaw, Anders Hamsten, Lise Lotte N Husemoen, Anne Tjønneland, Janne S Tolstrup, Eric Rimm, Joline W J Beulens, W M Monique Verschuren, N Charlotte Onland-Moret, Marten H Hofker, S Goya Wannamethee, Peter H Whincup, Richard Morris, Astrid M Vicente, Hugh Watkins, Martin Farrall, J Wouter Jukema, James Meschia, L Adrienne Cupples, Stephen J Sharp, Myriam Fornage, Charles Kooperberg, Andrea Z LaCroix, James Y Dai, Matthew B Lanktree, David S Siscovick, Eric Jorgenson, Bonnie Spring, Josef Coresh, Yun R Li, Sarah G Buxbaum, Pamela J Schreiner, R Curtis Ellison, Michael Y Tsai, Sanjay R Patel, Susan Redline, Andrew D Johnson, Ron C Hoogeveen, Hakon Hakonarson, Jerome I Rotter, Eric Boerwinkle, Paul I W de Bakker, Mika Kivimaki, Folkert W Asselbergs, Naveed Sattar, Debbie A Lawlor, John Whittaker, George Davey Smith, Kenneth Mukamal, Bruce M Psaty, James G Wilson, Leslie A Lange, Ajna Hamidovic, Aroon D Hingorani, Børge G Nordestgaard, Martin Bobak, David A Leon, Claudia Langenberg, Tom M Palmer, Alex P Reiner, Brendan J Keating, Frank Dudbridge, Juan P Casasbmj.comfalse10.1136/bmj.g4164Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data2014-07-10
10.1136/bmj.g4164http://dx.doi.org/doi:10.1136/bmj.g4164
doi:10.1136/bmj.g4164
2014-07-10falsebmj.com10.1136/bmj.g4164
endstream
endobj
6 0 obj
<<
/ITXT (5.1.3)
/Type /Pages
/Count 16
/Kids [9 0 R 21 0 R]
>>
endobj
8 0 obj
<<
/S /D
>>
endobj
9 0 obj
<<
/Parent 6 0 R
/Type /Pages
/Count 10
/Kids [3 0 R 22 0 R 23 0 R 24 0 R 25 0 R 26 0 R 27 0 R 28 0 R 29 0 R 30 0 R]
>>
endobj
10 0 obj
<<
/Length 31 0 R
/Filter /FlateDecode
>>
stream
x+ |
endstream
endobj
11 0 obj
<<
/Length 32 0 R
/Filter /FlateDecode
>>
stream
x+2P0P24327slC=K %
endstream
endobj
12 0 obj
<<
/Length 33 0 R
/Filter /FlateDecode
>>
stream
xڵ=rEy0nB쾜%aK-xv9,aw?՚Kwό K̬YՏG1uU
s6E_Xo~!߄Ծ'_tO^<+zy1vxq'q7z6.,>ŏawïٗzڳ?]nu9U5~vK\sn_oo56Fq!#'wGd` c%(3"t|>h$ EO3Q a}E>,0) &]*(#u%1QFX2b ݛq#Tx8WFgE=#=rg"'8Q|t?~od$HM }WB cV']MU˶[oo[32$V1O~fj8nmg"OOʈk\B%+6%A_i89_:`*`L@:by<~w3\bl%Twmmߌˢr/\.I {vv1w9:a+2&U07
kHM,{Uxnn"|nVG$qӼCbF3m2~JeK* ` 9&u5H*F$ﺪdt)$ɵ&2^jο̺psX՜ V؊d