Antibodies to chlamydial lipopolysaccharides in unstable angina pectoris
Section snippets
Study population
Blood samples of a prospective investigation on the effect of abciximab on death, myocardial infarction, and repeat intervention in patients with refractory angina were analyzed. The study design and results of the C7E3 Fab Antiplatelet Therapy in Unstable Refractory Angina (CAPTURE) study have been previously published.4 In brief, patients were eligible for study participation when they had refractory unstable angina. All patients underwent angiography and a culprit lesion suitable for
Patient characteristics
Serum samples were available from 1,096 of 1,265 patients included in the CAPTURE study. The average interval between enrolment and discharge was 5.8 days. Table 1 displays clinical characteristics of the patients analyzed. Variables associated with subsequent myocardial infarction or death were high age and high concentrations of CRP or TnT at enrollment. Potential confounders such as sex, age, diabetes, or cigarette consumption had no significant effect on anti-LPS IgG, IgA, or IgM titers.
Antibody titers
IgG
Discussion
In a large cohort of patients with refractory unstable angina followed for 6 months we found no association between baseline IgG or IgA antibodies directed against chlamydial LPS and subsequent coronary events. A low initial IgM titer was an independent predictor of reinfarction or death. There was no correlation of antibody titers with serum levels of CRP, an inflammatory marker known to predict future myocardial infarction.9, 10 Likewise, we found no correlation of titers with concentrations
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