References
Lendon CL, Lynch T, Norton J, McKeel DW Jr, Busfield F, Craddock N, Chakraverty S, Gopalakrishnan G, Shears SD, Grimmett W, Wilhelmsen KC, Hansen L, Morris JC, Goate AM (1998) Hereditary dysphasic disinhibition dementia: a frontotemporal dementia linked to 17q21–22. Neurology 50:1546–1555
Rademakers R, Cruts M, Dermaut B, Sleegers K, Rosso SM, Van den BM, Backhovens H, Van Swieten J, Duijn CM van, Van Broeckhoven C (2002) Tau negative frontal lobe dementia at 17q21: significant fine mapping of the candidate region to a 4.8 cM interval. Mol Psychiatry 7:1064–1074
Rosso SM, Kamphorst W, Graaf B de, Willemsen R, Ravid R, Niermeijer MF, Spillantini MG, Heutink P, Swieten JC van (2001) Familial frontotemporal dementia with ubiquitin-positive inclusions is linked to chromosome 17q21–22. Brain 124:1948–1957
Ponting CP, Hutton M, Nyborg A, Baker M, Jansen K, Golde TE (2002) Identification of a novel family of presenilin homologues. Hum Mol Genet 11:1037–1044
Cruts M, Van Broeckhoven C (1998) Presenilin mutations in Alzheimer’s disease. Hum Mutat 11:183–190
Duijn CM van, Hendriks L, Farrer LA, Backhovens H, Cruts M, Wehnert A, Hofman A, Van Broeckhoven C (1994) A population-based study of familial Alzheimer disease: linkage to chromosomes 14, 19, and 21. Am J Hum Genet 55:714–727
Baker M, Litvan I, Houlden H, Adamson J, Dickson D, Perez-Tur J, Hardy J, Lynch T, Bigio E, Hutton M (1999) Association of an extended haplotype in the Tau gene with progressive supranuclear palsy. Hum Mol Genet 8:711–715
Acknowledgements.
We acknowledge C. Ponting and K. Davies for sharing their data on PSH2 before publication. We acknowledge the VIB Genetic Service Facility (http://www.vibgeneticservicefacility.be/) for the genetic analyses. The research was funded by the Special Research Fund of the University of Antwerp, the Fund for Scientific Research Flanders (FWO-F), the InterUniversity Attraction Poles program P5/19 of the Federal Office of Scientific, Technical, and Cultural Affairs, the International Alzheimer Research Foundation, and The Medical Foundation Queen Elisabeth, Belgium, The Netherlands Organization for Scientific Research (NWO), and the Alzheimer Association USA. R.R. is a PhD fellow and M.C. a postdoctoral fellow of the FWO-F.
Author information
Authors and Affiliations
Corresponding author
Electronic Supplementary Material
Rights and permissions
About this article
Cite this article
Rademakers, R., Van den Broeck, M., Sleegers, K. et al. Absence of pathogenic mutations in presenilin homologue 2 in a conclusively 17-linked tau-negative dementia family. Neurogenetics 5, 79–80 (2004). https://doi.org/10.1007/s10048-003-0162-z
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10048-003-0162-z