Coronary artery disease (CAD) is a manifestation of atherosclerosis, a systemic inflammatory disease of the arteries that causes the formation of plaques in the artery walls. Different plaques may give rise to different symptoms: a gradual narrowing (stenosis) of the vessel by growth of a fibrous or calcific plaque will cause chest pain (due to cardiac ischemia) upon exertion, a condition called stable CAD. Sudden onset of chest pain, or chest pain at rest, is a symptom of unstable CAD or acute coronary syndrome (ACS), which is associated with thrombus formation on plaques, mostly due to rupture of a lipid-core lesion. The most severe form of this disease may lead to a myocardial infarction or heart attack.

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A.F.W. van der Steen (Ton) , G. van Soest (Gijs)
Erasmus University Rotterdam
This study was performed at Biomedical Engineering, Thorax Center, Erasmus MC Rotterdam, the Netherlands. A strong collaboration with Lehrstuhl für BioMolekulare Optik, Fakultät für Physik, Ludwig-Maximilians-Universität München is acknowledged. The study was supported by “Talent & Training China-Netherlands, PhD scholarship. Granted by China Scholarship Council. Finical support by the Dutch Heart Foundation for the publication of this thesis is gratefully acknowledged. Financial support for the printing of this thesis is kindly provided by: Erasmus Medical Center, TERUMO Co. and KINETRON BV.
Erasmus MC: University Medical Center Rotterdam

Wang, T. (2015, March 10). Heartbeat Optical Coherence Tomography. Erasmus University Rotterdam. Retrieved from http://hdl.handle.net/1765/77780