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  • A genetic association study of the IGF-1 gene and radiological osteoarthritis in a population-based cohort study (the Rotterdam study)

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A genetic association study of the IGF-1 gene and radiological osteoarthritis in a population-based cohort study (the Rotterdam study)
  1. I Meulenbelta,
  2. C Bijkerkc,
  3. H S Miedemaa,
  4. F C Breedveldb,
  5. A Hofmanc,
  6. H A Valkenburgd,
  7. H A P Polsc,d,
  8. P E Slagbooma,
  9. C M van Duijnc
  1. aTNO Prevention and Health, Department of Vascular and Connective Tissue Research, Gaubius Laboratory, Leiden, the Netherlands, bDepartment of Rheumatology and Department of Internal Medicine, University Hospital Leiden, the Netherlands, cDepartments of Epidemiology and Biostatistics, dand Internal Medicine III, eErasmus University Medical School, Rotterdam, the Netherlands
  1. Dr P E Slagboom, TNO Prevention and Health, Gaubius Laboratory, PO Box 2215, 2301 CE, Leiden, the Netherlands.

Abstract

OBJECTIVE A genetic association study was performed to investigate whether radiographical osteoarthritis (ROA) was associated with specific genotypes of the insulin-like growth factor I (IGF-1) gene.

METHODS Subjects aged 55–65 years were selected from a population-based study of which ROA at the knee, hip, spine, and hand was assessed. Genotypes were determined of a polymorphism in the promoter region of the IGF-1 gene.

RESULTS The IGF-1 locus was significantly associated with the presence of ROA (overall adjusted OR for heterozygous subjects = 1.9, 95% CI 1.2, 3.1 and for homozygous subjects 3.6, 95% CI 0.8, 16.2).

CONCLUSION These results suggest that variation at the IGF-1 locus is associated with ROA development and may play a part in ROA pathogenesis. To confirm these findings replication in another population-based sample is needed.

  • osteoarthritis
  • genetics
  • IGF-1

https://doi.org/10.1136/ard.57.6.371

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