%PDF-1.6
%
1 0 obj
<>
endobj
2 0 obj
<>stream
Rinske A. Gotink, John O. Younge, Machteld F. Wery, Elisabeth M. W. J. Utens, Michelle Michels, Dimitris Rizopoulos, Liesbeth F. C. van Rossum, Jolien W. Roos-Hesselink, Myriam M. G. Hunink
Online mindfulness as a promising method to improve exercise capacity in heart disease: 12-month follow-up of a randomized controlled trial
www.plosone.org
www.plosone.org
endstream
endobj
3 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 10 0 R/Annots 11 0 R/Contents 12 0 R/TrimBox[0 0 612 792]>>
endobj
11 0 obj
[13 0 R 14 0 R 15 0 R 16 0 R 17 0 R 18 0 R 19 0 R 20 0 R 21 0 R 22 0 R 23 0 R 24 0 R 25 0 R 26 0 R 27 0 R 28 0 R 29 0 R 30 0 R 31 0 R 32 0 R 33 0 R 34 0 R 35 0 R]
endobj
13 0 obj
<>/Border[0 0 0]/Dest(Rpone.0175923.ref001)>>
endobj
14 0 obj
<>/Border[0 0 0]/Dest(Rpone.0175923.ref002)>>
endobj
15 0 obj
<>/Border[0 0 0]/Dest(Rpone.0175923.ref003)>>
endobj
16 0 obj
<>/Border[0 0 0]/Dest(Rpone.0175923.ref004)>>
endobj
17 0 obj
<>/Border[0 0 0]/Dest(Rpone.0175923.ref005)>>
endobj
18 0 obj
<>/Border[0 0 0]/Dest(Rpone.0175923.ref006)>>
endobj
19 0 obj
<>/Border[0 0 0]/Dest(Rpone.0175923.ref007)>>
endobj
20 0 obj
<>/Border[0 0 0]/Dest(Rpone.0175923.ref011)>>
endobj
21 0 obj
<>/Border[0 0 0]/Dest(Rpone.0175923.ref012)>>
endobj
22 0 obj
<>/Border[0 0 0]/Dest(Rpone.0175923.ref013)>>
endobj
23 0 obj
<>/Border[0 0 0]/Dest(Rpone.0175923.ref014)>>
endobj
24 0 obj
<>/Border[0 0 0]/Dest(Rpone.0175923.ref015)>>
endobj
25 0 obj
<>/Border[0 0 0]/Dest(Rpone.0175923.ref016)>>
endobj
26 0 obj
<>/Border[0 0 0]/Dest(Rpone.0175923.ref017)>>
endobj
27 0 obj
<>/Border[0 0 0]/Dest(Rpone.0175923.ref018)>>
endobj
28 0 obj
<>/Border[0 0 0]/Dest(Rpone.0175923.ref019)>>
endobj
29 0 obj
<>/Border[0 0 0]/Dest(Rpone.0175923.ref021)>>
endobj
30 0 obj
<>/Border[0 0 0]/Dest(Rpone.0175923.ref022)>>
endobj
31 0 obj
<>/Border[0 0 0]/Dest(Rpone.0175923.ref023)>>
endobj
32 0 obj
<>/Border[0 0 0]/Dest(Rpone.0175923.ref024)>>
endobj
33 0 obj
<>/Border[0 0 0]/Dest(Rpone.0175923.ref024)>>
endobj
34 0 obj
<>/Border[0 0 0]/A 36 0 R>>
endobj
36 0 obj
<>
endobj
35 0 obj
<>/Border[0 0 0]/A 37 0 R>>
endobj
37 0 obj
<>
endobj
12 0 obj
[38 0 R 39 0 R 40 0 R 41 0 R 42 0 R 43 0 R 44 0 R 45 0 R 46 0 R 47 0 R 48 0 R 49 0 R 50 0 R 51 0 R 52 0 R 53 0 R 54 0 R 55 0 R 56 0 R 57 0 R 58 0 R 59 0 R 60 0 R 61 0 R]
endobj
38 0 obj
<>stream
q
0.83 0.64 0.02 0 k
301.0394 650.8346 m
305.8016 650.8346 l
h
f*
537.6756 637.7953 m
542.4378 637.7953 l
h
f*
500.4283 572.8252 m
505.1906 572.8252 l
h
f*
312.7748 546.8031 m
317.537 546.8031 l
h
f*
537.222 533.8205 m
541.9843 533.8205 l
h
f*
546.4063 533.8205 m
551.1685 533.8205 l
h
f*
501.2787 507.7984 m
506.0409 507.7984 l
h
f*
511.2 507.7984 m
520.7244 507.7984 l
h
f*
534.0472 481.8331 m
543.515 481.8331 l
h
f*
362.5512 455.811 m
372.0189 455.811 l
h
f*
402.7465 442.8283 m
412.2709 442.8283 l
h
f*
367.7102 429.789 m
377.2346 429.789 l
h
f*
295.8803 390.7843 m
305.4047 390.7843 l
h
f*
300.3591 364.8189 m
310.1102 364.8189 l
h
f*
314.7024 364.8189 m
324.5102 364.8189 l
h
f*
274.2803 351.8362 m
284.0882 351.8362 l
h
f*
289.4173 351.8362 m
299.1685 351.8362 l
h
f*
301.0961 325.8142 m
310.8472 325.8142 l
h
f*
412.8945 286.8094 m
422.7024 286.8094 l
h
f*
336.189 247.8047 m
345.9969 247.8047 l
h
f*
463.011 134.3055 m
472.5354 134.3055 l
h
f*
258.8598 95.3008 m
363.1181 95.3008 l
h
f*
0 g
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 707.8677 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Introduction)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 690.9165 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(In)Tj
1.1055 0 Td
(recent)Tj
2.7099 0 Td
(decades,)Tj
3.5659 0 Td
(Mindfulness-Based)Tj
7.8916 0 Td
(Stress)Tj
2.5115 0 Td
(Reduction)Tj
4.3597 0 Td
(\(MBSR\))Tj
3.4752 0 Td
(has)Tj
1.5421 0 Td
(grown)Tj
2.7949 0 Td
(to)Tj
1.0261 0 Td
(be)Tj
1.1509 0 Td
(a)Tj
0.652 0 Td
(well-known)Tj
-32.7853 -1.3039 Td
(adjunct)Tj
3.2371 0 Td
(intervention)Tj
5.176 0 Td
(in)Tj
1.0318 0 Td
(Western)Tj
3.617 0 Td
(healthcare)Tj
4.3257 0 Td
(with)Tj
2.0012 0 Td
(reproducible)Tj
5.3291 0 Td
(significant)Tj
4.388 0 Td
(psychological)Tj
-29.1059 -1.2982 Td
(improvements)Tj
6.032 0 Td
(in)Tj
1.0318 0 Td
(multiple)Tj
3.566 0 Td
(patient)Tj
3.0104 0 Td
(populations)Tj
4.9492 0 Td
(regarding)Tj
4.0932 0 Td
(depressive)Tj
4.354 0 Td
(symptomatology,)Tj
7.132 0 Td
(anxiety,)Tj
-34.1686 -1.2983 Td
(stress,)Tj
2.6191 0 Td
(and)Tj
1.7292 0 Td
(quality)Tj
2.9593 0 Td
(of)Tj
1.0148 0 Td
(life)Tj
1.44 0 Td
([)Tj
0.83 0.64 0.02 0 k
(1)Tj
0 g
(].)Tj
1.6044 0 Td
(Mindfulness)Tj
5.2101 0 Td
(is)Tj
0.8503 0 Td
(described)Tj
4.0536 0 Td
(as)Tj
1.0148 0 Td
(`the)Tj
1.6951 0 Td
(capacity)Tj
3.4695 0 Td
(to)Tj
1.0262 0 Td
(observe)Tj
3.2655 0 Td
(with)Tj
2.0012 0 Td
(open)Tj
-33.9531 -1.3039 Td
(and)Tj
1.7291 0 Td
(non-judgmental)Tj
6.7237 0 Td
(awareness)Tj
4.2576 0 Td
(towards)Tj
3.4072 0 Td
(all)Tj
1.1452 0 Td
(experiences)Tj
4.8643 0 Td
(within)Tj
2.8176 0 Td
(the)Tj
1.4683 0 Td
(present)Tj
3.1635 0 Td
(moment')Tj
3.8494 0 Td
([)Tj
0.83 0.64 0.02 0 k
(2)Tj
0 g
(].)Tj
1.6044 0 Td
(Tech-)Tj
-35.0303 -1.2983 Td
(niques)Tj
2.8516 0 Td
(taught)Tj
2.7723 0 Td
(as)Tj
1.0147 0 Td
(part)Tj
1.8426 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(eight-week)Tj
4.5807 0 Td
(MBSR)Tj
2.7893 0 Td
(training,)Tj
3.6454 0 Td
(mainly)Tj
2.9933 0 Td
(meditation,)Tj
4.8359 0 Td
(yoga)Tj
2.0806 0 Td
(and)Tj
1.7291 0 Td
(cognitive)Tj
-33.6186 -1.2982 Td
(reappraisal,)Tj
4.8188 0 Td
(teach)Tj
2.3301 0 Td
(participants)Tj
4.9549 0 Td
(to)Tj
1.0261 0 Td
(be)Tj
1.1509 0 Td
(more)Tj
2.3414 0 Td
(present)Tj
3.1635 0 Td
(in)Tj
1.0374 0 Td
(the)Tj
1.4684 0 Td
(here)Tj
1.9672 0 Td
(and)Tj
1.7291 0 Td
(now)Tj
1.9616 0 Td
(and)Tj
1.7291 0 Td
(to)Tj
1.0261 0 Td
(be)Tj
1.1509 0 Td
(more)Tj
2.3414 0 Td
(aware)Tj
2.5625 0 Td
(of)Tj
-36.7594 -1.304 Td
(bodily)Tj
2.7269 0 Td
(sensations)Tj
4.3313 0 Td
(and)Tj
1.7291 0 Td
(internal)Tj
3.3562 0 Td
(psychological)Tj
5.6012 0 Td
(processes,)Tj
4.1953 0 Td
(which)Tj
2.6532 0 Td
(can)Tj
1.6214 0 Td
(increase)Tj
3.4752 0 Td
(the)Tj
1.4684 0 Td
(ability)Tj
2.6929 0 Td
(to)Tj
1.0261 0 Td
(recog-)Tj
-34.8772 -1.2982 Td
(nize)Tj
1.8708 0 Td
(stress)Tj
2.3981 0 Td
(symptoms)Tj
4.354 0 Td
(at)Tj
0.9524 0 Td
(an)Tj
1.2076 0 Td
(early)Tj
2.1486 0 Td
(stage.)Tj
2.4265 0 Td
(Stress)Tj
2.5114 0 Td
(from)Tj
2.2054 0 Td
(the)Tj
1.4683 0 Td
(mindfulness)Tj
5.142 0 Td
(perspective)Tj
4.6998 0 Td
(refers)Tj
2.4548 0 Td
(to)Tj
1.0262 0 Td
(the)Tj
-34.8659 -1.2983 Td
(tension)Tj
3.1747 0 Td
(that)Tj
1.7745 0 Td
(arises)Tj
2.4378 0 Td
(when)Tj
2.4038 0 Td
(we)Tj
1.3322 0 Td
(have)Tj
2.058 0 Td
(negative)Tj
3.5319 0 Td
(experiences)Tj
4.8699 0 Td
(that)Tj
1.7802 0 Td
(we)Tj
1.3266 0 Td
(do)Tj
1.2529 0 Td
(not)Tj
1.576 0 Td
(want)Tj
2.1827 0 Td
([)Tj
0.83 0.64 0.02 0 k
(3)Tj
0 g
(])Tj
1.3776 0 Td
(:)Tj
0.4479 0 Td
(MBSR)Tj
2.7893 0 Td
(teaches)Tj
-34.316 -1.3039 Td
(acceptance)Tj
4.5694 0 Td
(of)Tj
1.0148 0 Td
(negative)Tj
3.5319 0 Td
(emotions)Tj
3.9515 0 Td
(or)Tj
1.0998 0 Td
(thoughts)Tj
3.7361 0 Td
(as)Tj
1.0148 0 Td
(passing)Tj
3.1691 0 Td
(experiences)Tj
4.8699 0 Td
(and)Tj
1.7291 0 Td
(thereby)Tj
3.2258 0 Td
(reducing)Tj
3.7757 0 Td
(the)Tj
-35.6879 -1.2983 Td
(stress)Tj
2.3924 0 Td
(associated)Tj
4.2576 0 Td
(with)Tj
2.0012 0 Td
(them)Tj
2.2847 0 Td
([)Tj
0.83 0.64 0.02 0 k
(4)Tj
0 g
(].)Tj
1.6044 0 Td
(People)Tj
2.897 0 Td
(with)Tj
1.9956 0 Td
(chronic)Tj
3.2882 0 Td
(conditions)Tj
4.4787 0 Td
(are)Tj
1.4457 0 Td
(prone)Tj
2.5908 0 Td
(to)Tj
1.0205 0 Td
(having)Tj
2.9196 0 Td
(negative)Tj
-33.1764 -1.2982 Td
(thoughts)Tj
3.7303 0 Td
(and)Tj
1.7291 0 Td
(feelings)Tj
3.2429 0 Td
(they)Tj
1.9275 0 Td
(do)Tj
1.2529 0 Td
(not)Tj
1.5761 0 Td
(want)Tj
2.1826 0 Td
(\(depression)Tj
4.8699 0 Td
(and)Tj
1.7291 0 Td
(anxiety)Tj
3.1125 0 Td
(comorbidity)Tj
5.1703 0 Td
(is)Tj
0.8504 0 Td
(high)Tj
2.0069 0 Td
([)Tj
0.83 0.64 0.02 0 k
(5)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.2586 0 Td
(6)Tj
0 g
(]\))Tj
1.3776 0 Td
(and)Tj
-36.0167 -1.2983 Td
(MBSR)Tj
2.7892 0 Td
(has)Tj
1.5421 0 Td
(been)Tj
2.1203 0 Td
(found)Tj
2.6192 0 Td
(to)Tj
1.0261 0 Td
(positively)Tj
4.0195 0 Td
(affect)Tj
2.3754 0 Td
(psychological)Tj
5.5956 0 Td
(outcomes)Tj
4.0875 0 Td
(in)Tj
1.0375 0 Td
(patients)Tj
3.3675 0 Td
(with)Tj
2.0013 0 Td
(chronic)Tj
-32.5812 -1.3039 Td
(pain,)Tj
2.211 0 Td
(obesity,)Tj
3.2655 0 Td
(hypertension,)Tj
5.6919 0 Td
(depression,)Tj
4.7565 0 Td
(anxiety)Tj
3.1067 0 Td
(and)Tj
1.7348 0 Td
(cardiovascular)Tj
5.9981 0 Td
(disease)Tj
3.0217 0 Td
([)Tj
0.83 0.64 0.02 0 k
(7)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(11)Tj
0 g
(].)Tj
3.0671 0 Td
(Over)Tj
2.2167 0 Td
(one)Tj
-35.07 -1.2983 Td
(million)Tj
3.118 0 Td
(people)Tj
2.8573 0 Td
(in)Tj
1.0375 0 Td
(the)Tj
1.4684 0 Td
(Netherlands)Tj
5.1193 0 Td
(suffer)Tj
2.4775 0 Td
(from)Tj
2.2053 0 Td
(cardiovascular)Tj
6.0037 0 Td
(disease,)Tj
3.2429 0 Td
(and)Tj
1.7291 0 Td
(each)Tj
2.0296 0 Td
(year)Tj
1.9048 0 Td
(100.000)Tj
-33.1934 -1.2982 Td
(get)Tj
1.4059 0 Td
(diagnosed.)Tj
4.5071 0 Td
(Healthcare)Tj
4.5694 0 Td
(costs)Tj
2.1713 0 Td
(are)Tj
1.4457 0 Td
(eight)Tj
2.2053 0 Td
(billion)Tj
2.8063 0 Td
(euro;)Tj
2.2791 0 Td
(9.2%)Tj
2.1486 0 Td
(of)Tj
1.0148 0 Td
(total)Tj
2.0069 0 Td
(healthcare)Tj
4.3313 0 Td
(costs)Tj
2.1713 0 Td
([)Tj
0.83 0.64 0.02 0 k
(12)Tj
0 g
(].)Tj
2.075 0 Td
(Car-)Tj
-35.138 -1.304 Td
(diovascular)Tj
4.7735 0 Td
(disease)Tj
3.016 0 Td
(is)Tj
0.8504 0 Td
(affected)Tj
3.3222 0 Td
(by)Tj
1.1849 0 Td
(stress:)Tj
2.6191 0 Td
(high)Tj
2.007 0 Td
(perceived)Tj
4.0535 0 Td
(stress)Tj
2.3981 0 Td
(is)Tj
0.8447 0 Td
(associated)Tj
4.2576 0 Td
(with)Tj
2.0013 0 Td
(a)Tj
0.6519 0 Td
(risk)Tj
1.7178 0 Td
(ratio)Tj
2.0976 0 Td
(of)Tj
-35.7956 -1.2982 Td
(1.27)Tj
1.8708 0 Td
(for)Tj
1.389 0 Td
(incident)Tj
3.5206 0 Td
(coronary)Tj
3.8381 0 Td
(heart)Tj
2.2733 0 Td
(disease)Tj
3.0218 0 Td
([)Tj
0.83 0.64 0.02 0 k
(13)Tj
0 g
(])Tj
1.8481 0 Td
(,)Tj
0.4479 0 Td
(presence)Tj
3.7134 0 Td
(of)Tj
1.0148 0 Td
(psychosocial)Tj
5.2497 0 Td
(stressors)Tj
3.634 0 Td
(is)Tj
0.8447 0 Td
(associated)Tj
-32.6662 -1.2983 Td
(with)Tj
1.9955 0 Td
(increased)Tj
4.0025 0 Td
(risk)Tj
1.7121 0 Td
(of)Tj
1.0148 0 Td
(acute)Tj
2.3301 0 Td
(myocardial)Tj
4.7055 0 Td
(infarction)Tj
4.1726 0 Td
([)Tj
0.83 0.64 0.02 0 k
(14)Tj
0 g
(])Tj
1.8481 0 Td
(and)Tj
1.7348 0 Td
(it)Tj
0.7824 0 Td
(negatively)Tj
4.2349 0 Td
(affects)Tj
2.7383 0 Td
(heart)Tj
2.2733 0 Td
(rate,)Tj
-33.5449 -1.3039 Td
(blood)Tj
2.5114 0 Td
(pressure)Tj
3.5773 0 Td
(and)Tj
1.7292 0 Td
(inflammatory)Tj
5.7089 0 Td
(factors)Tj
2.9027 0 Td
([)Tj
0.83 0.64 0.02 0 k
(15)Tj
0 g
(].)Tj
2.0806 0 Td
(On)Tj
1.5137 0 Td
(the)Tj
1.4683 0 Td
(contrary,)Tj
3.8551 0 Td
(low)Tj
1.6554 0 Td
(and)Tj
1.7348 0 Td
(variable)Tj
3.3562 0 Td
(heart)Tj
2.2734 0 Td
(rate)Tj
-34.367 -1.2983 Td
(and)Tj
1.7291 0 Td
(low)Tj
1.6554 0 Td
(blood)Tj
2.5171 0 Td
(pressure)Tj
3.5773 0 Td
(are)Tj
1.4457 0 Td
(associated)Tj
4.2576 0 Td
(with)Tj
1.9956 0 Td
(long-term)Tj
4.2519 0 Td
(survival)Tj
3.3392 0 Td
(and)Tj
1.7292 0 Td
(according)Tj
4.1895 0 Td
(to)Tj
1.0262 0 Td
(the)Tj
1.4683 0 Td
(ESC)Tj
-33.1821 -1.2982 Td
(Guidelines)Tj
4.524 0 Td
(cardiovascular)Tj
6.0038 0 Td
(patients)Tj
3.3675 0 Td
(are)Tj
1.4513 0 Td
(recommended)Tj
6.0378 0 Td
(to)Tj
1.0204 0 Td
(reduce)Tj
2.9197 0 Td
(stress)Tj
2.3981 0 Td
(in)Tj
1.0318 0 Td
(order)Tj
2.4208 0 Td
(to)Tj
1.0261 0 Td
(favorably)Tj
-32.2013 -1.304 Td
(affect)Tj
2.3754 0 Td
(these)Tj
2.2507 0 Td
(risk)Tj
1.7177 0 Td
(factors)Tj
2.9027 0 Td
([)Tj
0.83 0.64 0.02 0 k
(16)Tj
0 g
(].)Tj
0.01 Tc
-8.0503 -1.2982 Td
(MBSR)Tj
2.8459 0 Td
(has)Tj
1.5874 0 Td
(shown)Tj
2.9197 0 Td
(to)Tj
1.0488 0 Td
(improve)Tj
3.6793 0 Td
(heart)Tj
2.3471 0 Td
(rate,)Tj
2.041 0 Td
(breathing)Tj
4.1895 0 Td
(patterns)Tj
3.583 0 Td
(and)Tj
1.7745 0 Td
(blood)Tj
2.5852 0 Td
(pressure)Tj
3.6906 0 Td
(in)Tj
-33.4882 -1.2983 Td
(cardiovascular)Tj
6.1964 0 Td
(patients)Tj
3.481 0 Td
([)Tj
0.83 0.64 0.02 0 k
(17)Tj
0 g
(,)Tj
0.83 0.64 0.02 0 k
1.7915 0 Td
(18)Tj
0 g
(].)Tj
1.7914 0 Td
(Lower)Tj
2.8177 0 Td
(blood)Tj
2.5851 0 Td
(pressure)Tj
3.6851 0 Td
(and)Tj
1.7744 0 Td
(heart)Tj
2.3471 0 Td
(rate)Tj
1.8028 0 Td
(are)Tj
1.491 0 Td
(directly)Tj
3.3449 0 Td
(related)Tj
3.0387 0 Td
(to)Tj
-36.1471 -1.2983 Td
(exercise)Tj
3.4865 0 Td
(capacity)Tj
3.5887 0 Td
([)Tj
0.83 0.64 0.02 0 k
(19)Tj
0 g
()Tj
0.83 0.64 0.02 0 k
(21)Tj
0 g
(])Tj
3.4185 0 Td
(and)Tj
1.7688 0 Td
(a)Tj
0.669 0 Td
(walking)Tj
3.4583 0 Td
(distance)Tj
3.617 0 Td
(of)Tj
/F10 1 Tf
0 Tc
1.0431 0 Td
(<)Tj
/F5 1 Tf
0.01 Tc
(300)Tj
2.4605 0 Td
(meters)Tj
2.999 0 Td
(on)Tj
1.3039 0 Td
(the)Tj
1.5137 0 Td
(six)Tj
1.355 0 Td
(minute)Tj
3.1918 0 Td
(walking)Tj
-33.8738 -1.3039 Td
(test)Tj
1.6554 0 Td
(is)Tj
0.8787 0 Td
(a)Tj
0.6633 0 Td
(prognostic)Tj
4.6261 0 Td
(marker)Tj
3.2202 0 Td
(of)Tj
1.0431 0 Td
(subsequent)Tj
4.8472 0 Td
(cardiac)Tj
3.1975 0 Td
(death)Tj
2.5058 0 Td
(in)Tj
1.0601 0 Td
(patients)Tj
3.481 0 Td
(with)Tj
2.0522 0 Td
(mild)Tj
2.1373 0 Td
(to)Tj
1.0545 0 Td
(moderate)Tj
-32.4224 -1.2982 Td
(congestive)Tj
4.5297 0 Td
(heart)Tj
2.3471 0 Td
(failure)Tj
2.8743 0 Td
([)Tj
0.83 0.64 0.02 0 k
(22)Tj
0 g
(].)Tj
2.1486 0 Td
(The)Tj
1.8255 0 Td
(rationale)Tj
3.8721 0 Td
(of)Tj
1.0432 0 Td
(this)Tj
1.7291 0 Td
(randomized)Tj
5.2044 0 Td
(controlled)Tj
4.456 0 Td
(trial)Tj
1.9105 0 Td
(is)Tj
0.8731 0 Td
(that)Tj
1.8368 0 Td
(in)Tj
-34.6504 -1.2983 Td
(reducing)Tj
3.8834 0 Td
(stress,)Tj
2.7212 0 Td
(mindfulness)Tj
5.2951 0 Td
(therapy)Tj
3.3449 0 Td
(might)Tj
2.6645 0 Td
(influence)Tj
4.0422 0 Td
(heart)Tj
2.3471 0 Td
(rate,)Tj
2.0409 0 Td
(breathing)Tj
4.1896 0 Td
(patterns)Tj
3.583 0 Td
(and)Tj
-34.1119 -1.3039 Td
(blood)Tj
2.5851 0 Td
(pressure.)Tj
3.9288 0 Td
(These)Tj
2.6362 0 Td
(physiological)Tj
5.6239 0 Td
(effects)Tj
2.8233 0 Td
(may)Tj
1.9729 0 Td
(in)Tj
1.0602 0 Td
(turn)Tj
2.0239 0 Td
(improve)Tj
3.6793 0 Td
(exercise)Tj
3.4923 0 Td
(capacity)Tj
3.583 0 Td
(and)Tj
-33.4089 -1.2983 Td
(thus)Tj
1.9899 0 Td
(long-term)Tj
4.3766 0 Td
(outcome)Tj
3.8268 0 Td
(in)Tj
1.0601 0 Td
(cardiovascular)Tj
6.2022 0 Td
(patients)Tj
3.4752 0 Td
([)Tj
0.83 0.64 0.02 0 k
(23)Tj
0 g
(].)Tj
2.1487 0 Td
(In)Tj
1.1395 0 Td
(3-month)Tj
3.8438 0 Td
(post-intervention)Tj
7.4494 0 Td
(fol-)Tj
-35.5122 -1.2982 Td
(low-up,)Tj
3.3732 0 Td
(participants)Tj
5.125 0 Td
(who)Tj
1.9842 0 Td
(received)Tj
3.6453 0 Td
(an)Tj
1.2303 0 Td
(online)Tj
2.8459 0 Td
(mindfulness)Tj
5.2951 0 Td
(training)Tj
3.532 0 Td
(showed)Tj
3.3335 0 Td
(a)Tj
0.669 0 Td
(higher)Tj
2.8856 0 Td
(mean)Tj
-33.9191 -1.304 Td
(distance)Tj
3.6169 0 Td
(on)Tj
1.2983 0 Td
(the)Tj
1.5137 0 Td
(6-minute)Tj
4.0422 0 Td
(walk)Tj
2.1373 0 Td
(test,)Tj
1.8992 0 Td
(however)Tj
3.7077 0 Td
(this)Tj
1.7291 0 Td
(was)Tj
1.7405 0 Td
(small)Tj
2.398 0 Td
(and)Tj
1.7745 0 Td
(borderline)Tj
4.5524 0 Td
(statistically)Tj
4.7906 0 Td
(sig-)Tj
-35.2004 -1.2982 Td
(nificant)Tj
3.4072 0 Td
(\(13.4)Tj
2.279 0 Td
(metres,)Tj
3.2428 0 Td
(p)Tj
0.754 0 Td
(=)Tj
0.8107 0 Td
(0.050\))Tj
2.7723 0 Td
([)Tj
0.83 0.64 0.02 0 k
(24)Tj
0 g
(].)Tj
2.1487 0 Td
(This)Tj
2.0409 0 Td
(article)Tj
2.7836 0 Td
(reports)Tj
3.1691 0 Td
(the)Tj
1.508 0 Td
(results)Tj
2.9084 0 Td
(of)Tj
1.0431 0 Td
(the)Tj
1.5137 0 Td
(12-month)Tj
4.3313 0 Td
(fol-)Tj
-34.7128 -1.2983 Td
(low-up.)Tj
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 196.3842 cm
BT
/F2 1 Tf
1 TL
-0.0033 Tc
0 0 Td
(Materials)Tj
4.5071 0 Td
(and)Tj
1.989 0 Td
(methods)Tj
/F0 1 Tf
-6.4961 -1.5023 Td
(Study)Tj
2.7543 0 Td
(design)Tj
ET
Q
q
1 j
1 J
0 w
10 0 0 10 200.0125 161.4047 cm
BT
/F5 1 Tf
1 TL
-0.004 Tc
0 0 Td
(The)Tj
1.7801 0 Td
(current)Tj
3.1861 0 Td
(study)Tj
2.3868 0 Td
(is)Tj
0.8504 0 Td
(a)Tj
0.6519 0 Td
(single)Tj
2.5342 0 Td
(blinded,)Tj
3.4922 0 Td
(pragmatic)Tj
4.252 0 Td
(RCT)Tj
2.1146 0 Td
(performed)Tj
4.4674 0 Td
(at)Tj
0.9524 0 Td
(the)Tj
1.474 0 Td
(outpatient)Tj
4.337 0 Td
(cardiology)Tj
-32.4791 -1.3039 Td
(clinic)Tj
2.3924 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.474 0 Td
(Erasmus)Tj
3.6623 0 Td
(MC,)Tj
2.0013 0 Td
(Rotterdam,)Tj
4.7451 0 Td
(the)Tj
1.4684 0 Td
(Netherlands.)Tj
5.3461 0 Td
(Detailed)Tj
3.5773 0 Td
(description)Tj
4.7338 0 Td
(of)Tj
1.0148 0 Td
(design)Tj
2.812 0 Td
(and)Tj
-34.2423 -1.2982 Td
(methodology,)Tj
5.7259 0 Td
(and)Tj
1.7348 0 Td
(3-month)Tj
3.7474 0 Td
(results)Tj
2.8062 0 Td
(have)Tj
2.058 0 Td
(been)Tj
2.126 0 Td
(reported)Tj
3.6566 0 Td
(elsewhere)Tj
4.1046 0 Td
([)Tj
0.83 0.64 0.02 0 k
(24)Tj
0 g
(].)Tj
2.0806 0 Td
(Ethical)Tj
2.982 0 Td
(approval)Tj
3.702 0 Td
(was)Tj
-34.7241 -1.2983 Td
(obtained)Tj
3.7303 0 Td
(from)Tj
2.2054 0 Td
(the)Tj
1.474 0 Td
(Medical)Tj
3.4299 0 Td
(Ethics)Tj
2.6702 0 Td
(Committee)Tj
4.7395 0 Td
(of)Tj
1.0148 0 Td
(the)Tj
1.4683 0 Td
(Erasmus)Tj
3.668 0 Td
(Medical)Tj
3.4299 0 Td
(Center)Tj
2.948 0 Td
(and)Tj
1.7348 0 Td
(the)Tj
1.4684 0 Td
(study)Tj
-33.9815 -1.3039 Td
(complies)Tj
3.7813 0 Td
(with)Tj
2.0013 0 Td
(the)Tj
1.4683 0 Td
(Declaration)Tj
4.9096 0 Td
(of)Tj
1.0148 0 Td
(Helsinki.)Tj
3.8211 0 Td
(The)Tj
1.7858 0 Td
(study)Tj
2.3868 0 Td
(was)Tj
1.7007 0 Td
(registered)Tj
4.1499 0 Td
(with)Tj
2.0013 0 Td
(the)Tj
1.4683 0 Td
(Dutch)Tj
2.7326 0 Td
(trial)Tj
1.8368 0 Td
(regis-)Tj
-35.0586 -1.2983 Td
(try,)Tj
1.5703 0 Td
(NTR3453,)Tj
0.83 0.64 0.02 0 k
4.3143 0 Td
(http://www.trialregister)Tj
9.4053 0 Td
(.nl)Tj
0 g
(.)Tj
ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
36 737.6 l
576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
/I0 Do
Q
Q
Q
q
0 0 612 792 re
W* n
1 j
1 J
0 w
36 48.0002 m
576 48.0002 l
576 47.5002 l
36 47.5002 l
f*
0.83 0.64 0.02 0 k
81.5811 34.9228 m
237.8835 34.9228 l
h
f*
0 g
7.9999 0 0 7.9999 36 36 cm
BT
/F0 1 Tf
1 TL
-0.005 Tc
0 0 Td
(PLOS)Tj
2.8559 0 Td
(ONE)Tj
2.3669 0 Td
(|)Tj
0.83 0.64 0.02 0 k
0.4748 0 Td
(https://doi.or)Tj
5.4142 0 Td
(g/10.137)Tj
3.8198 0 Td
(1/journal.po)Tj
5.1236 0 Td
(ne.01759)Tj
4.089 0 Td
(23)Tj
0 g
2.0906 0 Td
(May)Tj
2.0906 0 Td
(9,)Tj
1.0346 0 Td
(2017)Tj
35.7806 0 Td
(2)Tj
0.7654 0 Td
(/)Tj
ET
endstream
endobj
39 0 obj
<>stream
endstream
endobj
40 0 obj
<>stream
endstream
endobj
41 0 obj
<>stream
endstream
endobj
42 0 obj
<>stream
endstream
endobj
43 0 obj
<>stream
endstream
endobj
44 0 obj
<>stream
endstream
endobj
45 0 obj
<>stream
endstream
endobj
46 0 obj
<>stream
endstream
endobj
47 0 obj
<>stream
endstream
endobj
48 0 obj
<>stream
endstream
endobj
49 0 obj
<>stream
endstream
endobj
50 0 obj
<>stream
endstream
endobj
51 0 obj
<>stream
endstream
endobj
52 0 obj
<>stream
endstream
endobj
53 0 obj
<>stream
endstream
endobj
54 0 obj
<>stream
endstream
endobj
55 0 obj
<>stream
endstream
endobj
56 0 obj
<>stream
endstream
endobj
57 0 obj
<>stream
endstream
endobj
58 0 obj
<>stream
endstream
endobj
59 0 obj
<>stream
endstream
endobj
60 0 obj
<>stream
endstream
endobj
61 0 obj
<>stream
BT
66.402 0 Td
(13)Tj
ET
Q
endstream
endobj
62 0 obj
<>/XObject<>>>/CropBox[0 0 612 792]/MediaBox[0 0 612 792]/Parent 10 0 R/Annots 64 0 R/Contents 65 0 R/TrimBox[0 0 612 792]>>
endobj
63 0 obj
<>
endobj
66 0 obj
<>
endobj
67 0 obj
<>stream
%!PS-AdobeFont-1.0
11 dict begin
/FontName /PI_chars_3 def
/FontType 1 def
/FontBBox {-11 -345 1373 718} readonly def
/FontMatrix [0.001 0 0 0.001 0 0] readonly def
/PaintType 0 def
/FontInfo 8 dict dup begin
/FullName (PI_chars_3) readonly def
/BaseFontName (PI_chars_3) def
end def
/Encoding 256 array
0 1 255 {1 index exch /.notdef put} for
dup 33 /exclam put
dup 34 /quotedbl put
dup 35 /numbersign put
dup 36 /dollar put
dup 37 /percent put
dup 38 /ampersand put
dup 39 /quoteright put
dup 40 /parenleft put
dup 41 /parenright put
dup 42 /asterisk put
dup 43 /plus put
dup 44 /comma put
dup 45 /hyphen put
dup 46 /period put
dup 47 /slash put
dup 49 /one put
dup 50 /two put
dup 51 /three put
dup 52 /four put
dup 53 /five put
dup 54 /six put
dup 55 /seven put
dup 56 /eight put
dup 58 /colon put
dup 60 /less put
dup 61 /equal put
dup 62 /greater put
dup 63 /question put
dup 64 /at put
dup 65 /A put
dup 66 /B put
dup 67 /C put
dup 68 /D put
dup 69 /E put
dup 70 /F put
dup 71 /G put
dup 72 /H put
dup 73 /I put
dup 74 /J put
dup 75 /K put
dup 76 /L put
dup 77 /M put
dup 78 /N put
dup 79 /O put
dup 80 /P put
dup 81 /Q put
dup 82 /R put
dup 83 /S put
dup 84 /T put
dup 85 /U put
dup 86 /V put
dup 87 /W put
dup 88 /X put
dup 89 /Y put
dup 90 /Z put
dup 91 /bracketleft put
dup 92 /backslash put
dup 93 /bracketright put
dup 94 /asciicircum put
dup 97 /a put
dup 98 /b put
dup 99 /c put
dup 100 /d put
dup 101 /e put
dup 102 /f put
dup 103 /g put
dup 104 /h put
dup 105 /i put
dup 106 /j put
dup 107 /k put
dup 108 /l put
dup 109 /m put
dup 110 /n put
dup 111 /o put
dup 112 /p put
dup 113 /q put
dup 114 /r put
dup 115 /s put
dup 116 /t put
dup 117 /u put
dup 118 /v put
dup 119 /w put
dup 120 /x put
dup 121 /y put
dup 122 /z put
dup 123 /braceleft put
dup 124 /bar put
dup 125 /braceright put
dup 126 /asciitilde put
readonly def
currentdict end
currentfile eexec
M#1H5 J6o\&rtS(#v\0\V7Fe༙OYx5-cY9^%Y6
(efIOldN"wȰ;)UƽoFg/rvV$JS8_oc@
o9-eGJp}[Do]mN=4*{ܯq=eU^t6¤/{zM4aܪ
Q:д'B-r^ܦ6y?rRnu S\U{Oλrs(Βƚ
#d29%s'ƈT1F8&\0Xd&&Zug'VPd]:>u=Q,?#(CV4'..|ӱ5 h
sȀg)fɘ`UXK^>] q\l#5pE"JO}rquáQBr/E7
QW5\GSlu{7ZH(PSf/O;̟w{ɴ}-K hA8!b!U>`#u?Vlnǝ19V+mg'QmA}S Y$í8n uJ ڒx3>[x0Z]
ͩw4M&1+pkC,sr"%q&OjbH{:5$65*S`cr;%s4Oӆe>T+6~pBOD!$c]"~r#nh6$38i˞[~Z}}rHmte9(1½=j{<\ ;? RA?c{Rf1'VԞ_-Lwo]`.l|zjf"![G1BYro˓9[-+z g!}RN+pX!M~HcFh@g%J6B)6!Lq>TX\ݪGF
PiQݓX~Fs;Ölo4/(C?+,ɖxۼ:xU^)
fd,`*>-:}=q$:\Xzcw1Nf(
ZkEeJXfэi@zXc\{a5qKg\5ݩv\Qe%1>OY̗$Y#P[)."^+{"bP]Bt&zeN6
іijDE% 0;̅
~~lfB>u'i4znym%tfԟ^נBTDS6-ghiWk/(r!!˶fc>趕%U