Acute dystonic reaction to metoclopramide in patients carrying homozygous cytochrome P450 2D6 genetic polymorphisms
BACKGROUND: Extrapyramidal syndromes (EPS) are clinically relevant side effects of metoclopramide which are often not anticipated. PATIENTS AND METHODS: Two patients who received metoclopramide developed an acute dystonic reaction. Symptoms disappeared after biperiden or trihexyphenidyl were given. Molecular analysis of the CYP2D6 gene was performed using a PCR-based method. RESULTS: Both patients were homozygous for inactive CYP2D6 alleles (CYP2D6*4/*4 and CYP2D6*4/*5), which are associated with slow drug metabolism. CONCLUSION: Metoclopramide-induced acute dystonic reactions may occur in patients carrying a CYP2D6 genetic polymorphism.
|Keywords||Acute Disease, Adult, Cytochrome P-450 CYP2D6/*genetics/metabolism, Dopamine Antagonists/*adverse effects, Dystonia/*chemically induced/genetics, Female, Humans, Leukemia, Myeloid/drug therapy, Lymphoma, Non-Hodgkin/drug therapy, Male, Metoclopramide/*adverse effects, Polymorphism, Genetic, Syndrome|
van der Padt, A., van Schaik, R.H.N., & Sonneveld, P.. (2006). Acute dystonic reaction to metoclopramide in patients carrying homozygous cytochrome P450 2D6 genetic polymorphisms. Netherlands Journal of Medicine. Retrieved from http://hdl.handle.net/1765/10407