The pathophysiology of affective disorders is largely unknown. In patients with various affective disorders the activity of pterins and related amino acids were investigated before and after clinical treatment. In particular the bipolar affective disorder could be characterized by less activity of tetrahydrobiopterin resulting in decreased synthesis of nitric oxide. After clinical recovery the same results were seen implicating that disturbances in the pterin metabilism could reflect a vulnerability for mood disorders.

Additional Metadata
Keywords arginine, bipolar disorder, depression, electroconvulsive therapy, mania, nepterin, nitric oxide, seasonal affective disorder, tetrahydrobiopterin
Promotor Verhoeven, W.M.A. (Wim)
Publisher Erasmus University Rotterdam
Sponsor StichtingJos Schaap-Feering, Rotterdam, the Netherlands , Verhoeven,. Prof. Dr. W.M.A. (promotor
Persistent URL hdl.handle.net/1765/10522
Citation
Hoekstra, R.. (2007, September 19). Pterins and affective disorders. Erasmus University Rotterdam. Retrieved from http://hdl.handle.net/1765/10522