Barrett’s Esophagus: a Molecular Characterization
Barrett’s esophagus is a premalignant condition that is most likely caused by gastroesophageal reflux. In the western world, about 30% of adults have reflux complaints, such as heartburn, and about 10% of reflux patients will develop Barrett’s esophagus . Barrett’s esophagus is characterized by chronic inflammation, and like other chronic inflammatory lesions, it is associated with cancer development. Patients with Barrett’s esophagus have a 30 times increased risk for the development of esophageal adenocarcinoma compared to the general population. Barrett’s esophagus can progress to esophageal adenocarcinoma through the intermediate stages low-grade dysplasia and high-grade dysplasia . Esophageal adenocarcinoma has a poor prognosis, the overall survival is only 15-20%.
|Keywords||Barrett’s esophagus, reflux complaints|
|Promotor||Kuipers, E.J. (Ernst)|
|Sponsor||AstraZeneca , Department of Gastroenterology and Hepatology, Erasmus MC , Jurriaanse Stichting , Kuipers, Prof. Dr. E.J. (promotor) , NVGE, section experimental gastroenterology , Pfizer , Roche Diagnostics|
Bax, D.A.. (2005, December 9). Barrett’s Esophagus: a Molecular Characterization. Retrieved from http://hdl.handle.net/1765/10564