Improving the Imaging of Small High-Density Structures in Computed Tomography

Computed Tomography (CT) imaging of small high-density structures such as calcifications and stents is highly relevant in diagnosis, treatment planning, and follow-up of patients with cardiovascular disease. Calcification quantification is increasingly used as a potential marker for cardiovascular disease. However, owing to image blur, accurate calcification quantification is compromised. In addition, blur of high intensity structures hampers the visualization of surrounding soft tissue structures. This for example affects the assessment of the degree of vessel stenoses at locations close to calcified atherosclerotic plaques and/or stent struts. The research described in this thesis focuses on the improved of visualization and quantification of small high density structures, in particular calcifications.