Cynomolgus macaques (Macaca fascicularis) infected with influenza virus A/Hong Kong/156/97 (H5N1) developed acute respiratory distress syndrome and fever associated with a necrotizing interstitial pneumonia. Reverse transcription PCR, virus isolation, and immunohistochemistry showed that the respiratory tract is the major target of the virus.

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Keywords *Influenza A Virus, H5N1 Subtype, *Influenza A virus/isolation & purification, Animals, Disease Models, Animal, Fever/pathology, Immunohistochemistry, Lung Diseases, Interstitial/pathology/virology, Macaca fascicularis, Necrosis, Orthomyxoviridae Infections/*virology, Research Support, Non-U.S. Gov't, Respiratory Distress Syndrome, Adult/pathology, Viscera/virology
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Rimmelzwaan, G.F., van Amerongen, G., Bestebroer, T.M., Fouchier, R.A.M., Osterhaus, A.D.M.E., & Kuiken, T.. (2001). Pathogenesis of influenza A (H5N1) virus infection in a primate model.. Journal of Virology, 75(14), 6687–6691. doi:10.1128/JVI.75.14.6687-6691.2001