Long-term follow-up of incomplete stent apposition in patients who received sirolimus-eluting stent for de novo coronary lesions: an intravascular ultrasound analysis.
BACKGROUND: Incomplete stent apposition (ISA) has been previously documented after sirolimus-eluting stent (SES) implantation. The aim of this study was to investigate the long-term intravascular ultrasound (IVUS) findings of ISA in patients who received SES. METHODS AND RESULTS: A total of 13 patients who received SES and showed ISA at follow-up IVUS (follow-up I) were investigated. IVUS was performed on all of these patients 12 months later (follow-up II). Quantitative ISA area measurement was also performed at follow-up I and II. No vascular remodeling was observed in the vessel segment with ISA; external elastic membrane area was 19.4+/-6.6 versus 19.5+/-6.4 mm2 at follow-up I and II, respectively. There was also no significant change in external elastic membrane area between vessel segment with ISA and without ISA (+1.5% versus -3.0%, respectively; P=0.27) at late follow-up. The ISA area, either including (2.5+/-1.7 versus 3.8+/-6.3 mm2; P=NS) or excluding (2.5+/-1.8 versus 2.4+/-1.7 mm2; P=NS) a single patient with aneurysm formation, was not significantly different between follow-up I and II. One patient manifested a coronary aneurysm in the stented segment at late follow-up that was probably present at the initial follow-up but masked by thrombus. It was successfully treated with a covered stent. All patients were asymptomatic, and no patient experienced late thrombotic occlusion. CONCLUSIONS: Vessel dimensions and area of ISA did not change over time, except for 1 coronary aneurysm that became apparent. ISA after implantation of a SES was not associated with adverse events at late follow-up.
|Keywords||*Stents/adverse effects/statistics & numerical data, Blood Vessel Prosthesis Implantation/adverse effects, Coronary Angiography, Coronary Arteriosclerosis/*therapy/*ultrasonography, Coronary Vessels/drug effects/ultrasonography, Drug Implants/adverse effects, Female, Follow-Up Studies, Humans, Male, Middle Aged, Randomized Controlled Trials/statistics & numerical data, Sirolimus/adverse effects/*therapeutic use, Time, Treatment Outcome, Ultrasonography, Interventional, Vascular Patency/drug effects|
|Note||Epub 2003 Nov 24|
|Persistent URL||dx.doi.org/10.1161/01.CIR.0000103666.25660.77, hdl.handle.net/1765/13265|
Degertekin, M., Serruys, P.W.J.C., Tanabe, K., Lee, C.H., Sousa, J.E., Colombo, A., … de Feyter, P.J.. (2003). Long-term follow-up of incomplete stent apposition in patients who received sirolimus-eluting stent for de novo coronary lesions: an intravascular ultrasound analysis.. Circulation (Baltimore), 108(22), 2747–2750. doi:10.1161/01.CIR.0000103666.25660.77