2021
Prevalence of radiologically isolated syndrome in a pediatric population-based cohort: A longitudinal description of a rare diagnosis
Publication
Publication
Background: Radiologically isolated syndrome (RIS) is typified by multiple sclerosis (MS)-like lesions on imaging, without clinical MS symptoms. The prevalence of pediatric RIS is largely unknown. Objective: The objective of the study is to provide an estimated RIS prevalence in a population-based cohort of children. Methods: We used data from the Generation R study to identify the childhood RIS prevalence. Results: In 5238 participants, only one RIS case was identified (prevalence: 0.02%; 95% confidence interval (CI): 0.00–0.11). During a 62-month follow-up, imaging examinations showed accrual of new focal demyelinating lesions; however, no clinical MS symptoms occurred. Conclusions: This study shows that the occurrence of RIS in children from the general population is rare.
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| doi.org/10.1177/1352458521989220, hdl.handle.net/1765/134355 | |
| Multiple Sclerosis: clinical and laboratory research | |
| Organisation | Department of Neurology |
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de Mol, C.L. (C. L.), Bruijstens, A.L. (A. L.), Jansen, P., Dremmen, M., Wong, Y. Y., van der Lugt, A., … Neuteboom, R. (2021). Prevalence of radiologically isolated syndrome in a pediatric population-based cohort: A longitudinal description of a rare diagnosis. Multiple Sclerosis: clinical and laboratory research. doi:10.1177/1352458521989220 |
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