Four-year angiographic and intravascular ultrasound follow-up of patients treated with sirolimus-eluting stents.
BACKGROUND: Despite the proven superiority of sirolimus-eluting stents (SESs) compared with bare stents in the first year after implantation, long-term outcomes of patients treated with these novel devices remain unknown. Our goal was to evaluate the clinical, angiographic, and intravascular ultrasound (IVUS) outcomes of patients treated with SESs 4 years after implantation. METHODS AND RESULTS: The study included 30 patients treated with sirolimus-eluting Bx Velocity stenting (slow release [SR; n=15] and fast release [FR; n=15]). Twenty-six patients underwent 4-year angiographic and IVUS follow-up and had matched assessments at all time points (index and 4-, 12-, 24-, and 48-month follow-up). One death occurred during the study period in a patient with a patent SES. There were no target-vessel revascularizations or thromboses between 2- and 4-year follow-up examinations. There was no stent thrombosis, target-lesion revascularization, death, or myocardial infarction in the SR group up to 4 years. Cumulative event-free survival rate was 87% for the total population (80% in the FR group and 93% in the SR group). In-stent late loss was slightly greater in the FR group (0.41+/-0.49 mm) than the SR group (0.09+/-0.23) after 4 years. One patient in the FR group had a 52% in-stent restenosis lesion. Percent neointimal hyperplasia volume, as detected by IVUS, remained minimal after 4 years (FR=9.1% and SR=5.7%). CONCLUSIONS: This study confirms the longevity of the optimal outcomes observed in patients treated with sirolimus-eluting Bx Velocity stents 4 years after implantation. In-stent lumen dimensions remained essentially unchanged at 4-year follow-up, particularly in the population treated with the currently available SES (SR formulation).
|Keywords||Cardiovascular Diseases, Coronary Angiography, Disease-Free Survival, Follow-Up Studies, Graft Occlusion, Vascular, Humans, Incidence, Kinetics, Sirolimus/*administration & dosage, Stents/*adverse effects/standards, Treatment Outcome, Ultrasonography, Interventional|
|Note||Epub 2005 Apr 25|
|Persistent URL||dx.doi.org/10.1161/01.CIR.0000164271.01172.1A, hdl.handle.net/1765/13788|
Sousa, J.E., Costa, M.A., Feres, F., Seixas, A.C., Tanajura, L.F., Mattos, L.A., … Abizaid, A.C.. (2005). Four-year angiographic and intravascular ultrasound follow-up of patients treated with sirolimus-eluting stents.. Circulation (Baltimore), 111(18), 2326–2329. doi:10.1161/01.CIR.0000164271.01172.1A