The E4 allele of the apolipoprotein E gene (APOE) is a well-established determinant of Alzheimer's disease but its relation to cognitive function is much less understood. We studied the age-specific effects of the APOE*E4 allele on cognitive function and cardiovascular risk factors in 2208 related individuals. APOE*E4 allele was significantly associated with reduced test scores for Adult Verbal Learning Test, particularly on the memory and learning sub domains, in persons older than 50 years of age. The effect of APOE*E4 was independent of the effect of APOE*E4 on vascular risk factors and most pronounced on learning ability. Our findings suggest that APOE*E4 has an effect on cognitive function predominantly in the elderly, independent of vascular risk factors.

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Keywords APOE, Age, Alzheimer's disease, Cognitive function, Genetic analysis
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Journal Neurobiology of Aging: age-related phenomena, neurodegeneration and neuropathology
Liu, F, Pardo Cortes, L.M, Schuur, M, Sanchez-Juan, P, Isaacs, A.J, Sleegers, K, … van Duijn, C.M. (2008). The apolipoprotein E gene and its age-specific effects on cognitive function. Neurobiology of Aging: age-related phenomena, neurodegeneration and neuropathology, 31(10), 1831–1833. doi:10.1016/j.neurobiolaging.2008.09.015