Id1 is frequently overexpressed in many cancer cells, but the functional significance of these findings is not known. To determine if Id1 could contribute to the development of hematopoietic malignancy, we reconstituted mice with hematopoietic cells overexpressing Id1. We showed for the first time that deregulated expression of Id1 leads to a myeloproliferative disease in mice, and immortalizes myeloid progenitors in vitro. In human cells, we demonstrate that Id genes are expressed in human acute myelogenous leukemia cells, and that knock down of Id1 expression inhibits leukemic cell line growth, suggesting that Id1 is required for leukemic cell proliferation. These findings established a causal relationship between Id1 overexpression and hematologic malignancy. Thus, deregulated expression of Id1 may contribute to the initiation of myeloid malignancy, and Id1 may represent a potential therapeutic target for early stage intervention in the treatment of hematopoietic malignancy.

Additional Metadata
Keywords Id1, Leukemia, Myeloproliferative disease, Prevention, Therapeutic target
Persistent URL dx.doi.org/10.1038/onc.2008.175, hdl.handle.net/1765/14849
Citation
Suh, H.C, Leeanansaksiri, W, Ji, M, Klarmann, K.D, Renn, K, Gooya, J, … Keller, J.R. (2008). Id1 immortalizes hematopoietic progenitors in vitro and promotes a myeloproliferative disease in vivo. Oncogene: including Oncogene Reviews, 27(42), 5612–5623. doi:10.1038/onc.2008.175